| Budget Amount *help |
¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2016: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2015: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2014: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Outline of Final Research Achievements |
Obesity has become more prevalent in most developed countries over the past few decades, and is increasingly recognized as a major risk for several common types of cancer. Although weight loss by exercise and/or dietary control ameliorates obesity-induced metabolic syndromes, the worldwide obesity epidemic has shown no signs of abating. Therefore, more effective methods are needed to prevent obesity-associated cancer development. Toward this purpose, a better understanding of the mechanisms underlying obesity-associated cancer is urgently required. The exact molecular mechanisms that integrate these events have remained unclear. Recently, we reported that obesity induces alterations of gut microbiota, thereby increasing the levels of deoxycholic acid promotes liver cancer development in mice. Notably, we found that obesity also promotes lung cancer development in mice. In this study, we investigated the molecular mechanism about the obesity-induced lung cancer development.
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