Pathological significance of T cell plasticity in arthritis and development of novel therapies
Project/Area Number |
26713015
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Partial Multi-year Fund |
Research Field |
Experimental pathology
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Research Institution | The University of Tokyo |
Principal Investigator |
Komatsu Noriko 東京大学, 大学院医学系研究科(医学部), 助教 (20553358)
|
Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2016: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2015: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2014: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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Keywords | 関節リウマチ / 自己免疫疾患 / T細胞 / 免疫学 |
Outline of Final Research Achievements |
It is widely known that the imbalance between pathogenic T cells and regulatory T cells is involved in the pathogenesis of rheumatoid arthritis (RA), however, the fundamental treatment for RA has not been established. We previously reported that a novel pathogenic T cell subset which is converted from regulatory T cells exacerbated autoimmune arthritis, however its effector mechanism remained to be elucidated. Here, by genetic methods, we clarified the importance of the interaction between the pathogenic T cell subset and tissue resident-mesenchymal cells in the bone destruction in arthritis. By comprehensive analysis, we identified several molecules that are specifically expressed in the new pathogenic T cell subset, which will contribute to the development of novel therapeutic strategies for rheumatoid arthritis in the future.
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Report
(5 results)
Research Products
(40 results)
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[Journal Article] LOX Fails to Substitute for RANKL in Osteoclastogenesis2017
Author(s)
Tsukasaki M, Hamada K, Okamoto K, Nagashima K, Terashima A, Komatsu N, Win S, Okamura T, Nitta T, Yasuda H, Penninger JM, Takayanagi H
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Journal Title
Journal of Bone and Mineral Research
Volume: 32
Issue: 3
Pages: 434-439
DOI
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Peer Reviewed / Int'l Joint Research
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[Presentation] 免疫が骨を壊すしくみ2016
Author(s)
小松紀子
Organizer
第62回日本病理学会 秋期特別総会
Place of Presentation
金沢市文化ホール(金沢市)
Year and Date
2016-11-10
Related Report
Invited
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[Presentation] Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis2014
Author(s)
N. Komatsu, K. Okamoto, S. Sawa, T. Nakashima, M. Oh-hora, T. Kodama, S. Tanaka, J.A. Bluestone, and H. Takayanagi
Organizer
5th International Conference on Osteoimmunology:
Place of Presentation
Double Tree Kos Conference Center, Kos, Greece
Year and Date
2014-06-17
Related Report
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