Studies on entry and nuclear egress of Herpes Simplex Virus

• Project/Area Number: 26713017
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Virology
• Research Institution: The University of Tokyo
• Principal Investigator: Arii Jun 東京大学, 医科学研究所, 助教 (30704928)
• Research Collaborator: KAWAGUCHI Yasushi 東京大学, 医科学研究所, 教授 ; KATO Akihisa 東京大学, 医科学研究所, 助教 ; KOYANAGI Naoto 東京大学, 医科学研究所, 特任研究員
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000); Fiscal Year 2016: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000); Fiscal Year 2015: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000); Fiscal Year 2014: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
• Keywords: HSV / 糖タンパク質 / 膜タンパク質 / 核膜 / 細胞膜 / ウイルス粒子形成 / ウイルス侵入 / 粒子形成 / 核膜通過 / glycoprotein / ウイルス / レセプター / 粒子形成過程 / エントリー

Outline of Final Research Achievements

We investigated the mechanism by which HSV passes though cellular membranes. We successfully identified several viral or cellular factors which promote passage through cellular membranes of HSV. As these steps are essential for viral life cycle, our results may indicate new prophylactic and therapeutic approaches for the development of antiherpetic drugs.

Research Products

• [Journal Article] Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication. (2018)
  • Author(s): Maruzuru Y, Ichinohe T, Sato R, Miyake K, Okano T, Suzuki T, Koshiba T, Koyanagi N, Tsuda S, Watanabe M, Arii J, Kato A, Kawaguchi Y.
  • Journal Title: Cell Host Microbe. Volume: 23 Issue: 2 Pages: 254-265
  • DOI: 10.1016/j.chom.2017.12.014
  • Peer Reviewed / Open Access
• [Journal Article] Herpes simplex virus-1 evasion of CD8+ T cell accumulation contributes to viral encephalitis. (2017)
  • Author(s): Koyanagi N, Imai T, Shindo K, Sato A, Fujii W, Ichinohe T, Takemura N, Kakuta S, Uematsu S, Kiyono H, Maruzuru Y, Arii J, Kato A, Kawaguchi Y.
  • Journal Title: J Clin Invest. Volume: 127 Issue: 10 Pages: 3784-3795
  • DOI: 10.1172/jci92931
  • Peer Reviewed / Open Access
• [Journal Article] Herpes Simplex Virus 1 Small Capsomere-Interacting Protein VP26 Regulates Nucleocapsid Maturation. (2017)
  • Author(s): Kobayashi R, Kato A, Sagara H, Watanabe M, Maruzuru Y, Koyanagi N, Arii J, Kawaguchi Y.
  • Journal Title: J Virol. Volume: 91 Issue: 18
  • DOI: 10.1128/jvi.01068-17
  • Peer Reviewed / Open Access
• [Journal Article] Herpes Simplex Virus 1 UL34 Protein Regulates the Global Architecture of the Endoplasmic Reticulum in Infected Cells. (2017)
  • Author(s): F. Maeda, J. Arii, Y. Hirohata, Y. Maruzuru, N. Koyanagi, A. Kato and Y. Kawaguchi.
  • Journal Title: J. Virol. Volume: 印刷中 Issue: 12
  • DOI: 10.1128/jvi.00271-17
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Roles of Us8A and its phosphorylation mediated by Us3 in herpes simplex virus 1 pathogenesis. (2016)
  • Author(s): A. Kato, T. Ando, S. Oda, M. Watanabe, N. Koyanagi, J. Arii and Y. Kawaguchi.
  • Journal Title: Journal of Virology Volume: 印刷中 Issue: 12 Pages: 5622-5635
  • DOI: 10.1128/jvi.00446-16
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] p53 is a Host Cell Regulator during Herpes Simplex Encephalitis. (2016)
  • Author(s): Maruzuru Y, Koyanagi N, Takemura N, Uematsu S, Matsubara D, Suzuki Y, Arii J, Kato A, Kawaguchi Y.
  • Journal Title: J Virol. Volume: 90(15) Issue: 15 Pages: 6738-6745
  • DOI: 10.1128/jvi.00846-16
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Interaction between Herpes Simplex Virus 1 Tegument Proteins UL51 and UL14 and Its Role in Virion Morphogenesis. (2016)
  • Author(s): S. Oda, J. Arii, N. Koyanagi, A. Kato, and Y. Kawaguchi.
  • Journal Title: Journal of Virology Volume: 90 Issue: 19 Pages: 8754-8767
  • DOI: 10.1128/jvi.01258-16
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Multiple Roles of the Cytoplasmic Domain of Herpes Simplex Virus 1 Envelope Glycoprotein D in Infected Cells. (2016)
  • Author(s): Arii J, Shindo K, Koyanagi N, Kato A, Kawaguchi Y.
  • Journal Title: J Virol. Volume: 90 Pages: 10170-10181
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Interactome Analysis of Herpes Simplex Virus 1 Envelope Glycoprotein H. (2015)
  • Author(s): Y. Hirohata, A. Kato, M. Oyama, H. Kozuka-Hata, N. Koyanagi, J. Arii and Y. Kawaguchi.
  • Journal Title: Microbiology and Immunology Volume: 印刷中 Issue: 6 Pages: 331-7
  • DOI: 10.1111/1348-0421.12255
  • NAID: 40020510068
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Function of the Herpes Simplex Virus 1 Small Capsid Protein VP26 is Regulated by Phosphorylation at a Specific Site. (2015)
  • Author(s): R. Kobayashi, A. Kato, S. Oda, N. Koyanagi, M. Oyama, H. Kozuka-Hata, J. Arii, and Y. Kawaguchi.
  • Journal Title: Journal of Virology Volume: 89 Issue: 11 Pages: 6141-7
  • DOI: 10.1128/jvi.00547-15
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Herpes simplex virus 1 recruits CD98 heavy chain and β1 integrin to the nuclear membrane for viral de-envelopment. (2015)
  • Author(s): Y. Hirohata, J. Arii, Z. Liu, K. Shindo, M. Oyama, H. Kozuka-Hata, H. Sagara, A. Kato, and Y. Kawaguchi.
  • Journal Title: Journal of Virology Volume: 89 Issue: 15 Pages: 7799-812
  • DOI: 10.1128/jvi.00741-15
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Role of Host Cell p32 in Herpes Simplex Virus 1 De-Envelopment during Viral Nuclear Egress. (2015)
  • Author(s): Liu Z, Kato A, Oyama M, Kozuka-Hata H, Arii J, Kawaguchi Y.
  • Journal Title: J Virol. Volume: 89 Pages: 8982-8998
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Characterization of a Herpes Simplex Virus 1 (HSV-1) Chimera in Which the Us3 Protein Kinase Gene Is Replaced with the HSV-2 Us3 Gene. (2015)
  • Author(s): Shindo K, Kato A, Koyanagi N, Sagara H, Arii J, Kawaguchi Y.
  • Journal Title: J Virol. Volume: 90 Issue: 1 Pages: 457-473
  • DOI: 10.1128/jvi.02376-15
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Non-Muscle Myosin Heavy Chain IIB Mediates Herpes Simplex Virus 1 Entry. (2015)
  • Author(s): J. Arii, Y. Hirohata, A. Kato and Y. Kawaguchi.
  • Journal Title: Journal of Virology Volume: 89 Issue: 3 Pages: 1879-88
  • DOI: 10.1128/jvi.03079-14
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Phosphorylation of Herpes Simplex Virus 1 dUTPase Regulates Viral Virulence and Genome Integrity by Compensating for Low Cellular dUTPase Activity in the Central Nervous System. (2015)
  • Author(s): A. Kato, J. Arii, Y. Koyanagi, and Y. Kawaguchi.
  • Journal Title: Journal of Virology Volume: 89 Issue: 1 Pages: 241-8
  • DOI: 10.1128/jvi.02497-14
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The UL12 Protein of Herpes Simplex Virus 1 Is Regulated by Tyrosine Phosphorylation. (2014)
  • Author(s): H. Fujii, A. Kato, M. Mugitani, Y. Kashima, M. Oyama, H. Kozuka-Hata, J. Arii, and Y. Kawaguchi.
  • Journal Title: Journal of Virology Volume: 88 Issue: 18 Pages: 10624-34
  • DOI: 10.1128/jvi.01634-14
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Phosphorylation of Herpes Simplex Virus 1 dUTPase Up-regulated Viral dUTPase Activity to Compensate for Low Cellular dUTPase Activity for Efficient Viral Replication. (2014)
  • Author(s): A. Kato, Y. Hirohata, J. Arii, and Y. Kawaguchi.
  • Journal Title: Journal of Virology Volume: 88 Issue: 14 Pages: 7776-85
  • DOI: 10.1128/jvi.00603-14
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The Role of Herpes Simplex Virus 1 Immediate-Early Protein ICP22 in Viral Nuclear Egress. (2014)
  • Author(s): Y. Maruzuru, K. Shindo, Z. Liu, M. Oyama, H. Kozuka-Hata, J. Arii, A. Kato and Y. Kawaguchi.
  • Journal Title: Journal of Virology Volume: 88 Issue: 13 Pages: 7445-54
  • DOI: 10.1128/jvi.01057-14
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Herpes Simplex Virus 1 UL47 Interacts with Viral Nuclear Egress Factors UL31, UL34, and Us3 and Regulates Viral Nuclear Egress. (2014)
  • Author(s): Z. Liu, A. Kato, K. Shindo, T. Noda, H. Sagara, Y. Kawaoka, J. Arii, and Y. Kawaguchi.
  • Journal Title: Jounarl of Virology Volume: 88 Issue: 9 Pages: 4657-67
  • DOI: 10.1128/jvi.00137-14
  • Peer Reviewed / Open Access
• [Presentation] 単純ヘルペスウイルス（HSV）の細胞間伝播を促進する宿主細胞膜タンパク質の同定 (2017)
  • Author(s): 渡邉瑞季, 有井潤, 下島昌幸, 加藤哲久, 川口寧
  • Organizer: 第14回ウイルス学キャンプ in 湯河原
• [Presentation] 単純ヘルペスウイルスと宿主細胞膜との相互作用 (2017)
  • Author(s): 有井 潤
  • Organizer: 第14回ウイルス学キャンプ in 湯河原
  • Invited
• [Presentation] HSV-1 UL51 リン酸化制御機構と細胞種依存的な新規機能の解明 (2017)
  • Author(s): 尾田真也, 加藤哲久, 丸鶴雄平, 小栁直人, 有井潤, 川口寧
  • Organizer: 第31回ヘルペスウイルス研究会
• [Presentation] HSV-2のウイルス増殖および病原性はUL13プロテインキナーゼのリン酸化によって制御される (2017)
  • Author(s): 小栁直人, 加藤哲久, 丸鶴雄平, 有井潤, 川口寧
  • Organizer: 第31回ヘルペスウイルス研究会
• [Presentation] ESCRT-IIIは小胞媒介性核外輸送における膜切断を仲介し、核内膜の恒常性維持に寄与する (2017)
  • Author(s): 有井潤, 渡邉瑞季, 前田史雄, 加藤哲久, 川口寧
  • Organizer: 第31回ヘルペスウイルス研究会
• [Presentation] Inhibition of AIM2 inflammasome activation by an HSV-1 virion component enables efficient viral replication in vivo (2017)
  • Author(s): Yuhei Maruzuru, Takeshi Ichinohe, Naoto Koyanagi, Jun Arii, Akihisa Kato and Yasushi Kawaguchi
  • Organizer: 第31回ヘルペスウイルス研究会
• [Presentation] 単純ヘルペスウイルス1型UL34は小胞体の形態制御を行い、ヌクレオカプシドの核出芽輸送制御因子の核膜への集積に関与する (2017)
  • Author(s): 前田史雄, 廣畑吉崇, 有井潤, 加藤哲久, 川口寧
  • Organizer: 第31回ヘルペスウイルス研究会
• [Presentation] 単純ヘルペスウイルス(HSV)の細胞間感染を促進する宿主タンパク質の同定 (2017)
  • Author(s): 渡邉瑞季, 有井潤, 下島昌幸, 加藤哲久, 川口寧
  • Organizer: 第31回ヘルペスウイルス研究会
• [Presentation] ヘルペスウイルスカプシドの核外輸送は宿主機構のハイジャックによって達成される (2017)
  • Author(s): 有井潤, 渡邉瑞季, 川口寧
  • Organizer: 第160回日本獣医学会学術集会
• [Presentation] 単純ヘルペスウイルスgEと相互作用して細胞間感染を促進する宿主因子の同定 (2017)
  • Author(s): 渡邉瑞季, 有井潤, 下島昌幸, 川口寧
  • Organizer: 第160回日本獣医学会学術集会
• [Presentation] ESCRT-III mediates vesicle-mediated nuclear export to regulate nuclear egress of HSV-1 capsids and integrity of the inner nuclear membrane (2017)
  • Author(s): Jun Arii, Mizuki Watanabe, Fumio Maeda, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi
  • Organizer: 第65回日本ウイルス学会学術集会
• [Presentation] Cell type-specific regulation of the nuclear egress of herpes simplex virus type1 by phosphorylation of UL51 Ser-184 (2017)
  • Author(s): Shinya Oda, Akihisa Kato, Yuhei Maruzuru, Naoto Koyanagi, Jun Arii, Yasushi Kawaguchi
  • Organizer: 第65回日本ウイルス学会学術集会
• [Presentation] Evasion of AIM2-Dependent Inflamasome Activation by Herpes Simplex Virus 1 Virion Protein Enables Efficient Viral Replication In Vivo (2017)
  • Author(s): Yuhei Maruzuru, Takeshi Ichinohe, Naoto Koyanagi, Zhuoming Liu, Tomoko Ando, Jun Arii, Akihisa Kato, Yasushi Kawaguchi
  • Organizer: 第65回日本ウイルス学会学術集会
• [Presentation] A host cell membrane protein interacts with HSV-1 gE and promotes viral cell-to-cell spread (2017)
  • Author(s): Mizuki Watanabe, Jun Arii, Masayuki Shimojima, Akihisa Kato, Yasushi Kawaguchi
  • Organizer: 第65回日本ウイルス学会学術集会
• [Presentation] Function of the herpes simplex virus 2 protein kinase UL13 in vitro and in vivo is regulated by phosphorylation (2017)
  • Author(s): Naoto Koyanagi, Akihisa Kato, Yuhei Maruzuru, Jun Arii, Yasushi Kawaguchi
  • Organizer: 第65回日本ウイルス学会学術集会
• [Presentation] Molecular mechanism of HSV-1 nuclear egress (2017)
  • Author(s): Jun Arii
  • Organizer: CAS-IMSUT Workshop on Infectious Diseases
  • Int'l Joint Research
• [Presentation] Inhibition of AIM2 inflammasome activation by an HSV-1 virion component enables efficient viral replication in vivo (2017)
  • Author(s): Yuhei Maruzuru, Takeshi Ichinohe, Naoto Koyanagi, Jun Arii, Akihisa Kato and Yasushi Kawaguchi
  • Organizer: 42nd Annual International Herpesvirus Workshop
  • Int'l Joint Research
• [Presentation] Identification of a host cell membrane protein that interacts with HSV-1 gE and promotes viral cell-to-cell spread (2017)
  • Author(s): Mizuki Watanabe, Jun Arii, Masayuki Shimojima, Naoto Koyanagi, Yuhei Maruzuru, Akihisa Kato and Yasushi Kawaguchi
  • Organizer: 42nd Annual International Herpesvirus Workshop
  • Int'l Joint Research
• [Presentation] Herpes simplex virus type 1 UL51 Protein Regulates Virion Morphogenesis in the Nucleus in a Cell type and Phosphorylation-Dependent Manner (2017)
  • Author(s): Shinya Oda, Akihisa Kato, Naoto Koyanagi, Yuhei Maruzuru, Jun Arii and Yasushi Kawaguchi
  • Organizer: 42nd Annual International Herpesvirus Workshop
  • Int'l Joint Research
• [Presentation] ESCRT-III mediates vesicle-mediated nuclear export and regulates the integrity of the inner nuclear membrane (2017)
  • Author(s): Jun Arii, Mizuki Watanabe, Fumio Maeda, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato and Yasushi Kawaguchi
  • Organizer: 42nd Annual International Herpesvirus Workshop
  • Int'l Joint Research
• [Presentation] Regulation of herpes simplex virus-2 UL13 protein kinase by phosphorylation is important for viral replication, pathogenic manifestations, and virulence in vivo (2017)
  • Author(s): Naoto Koyanagi, Akihisa Kato, Yuhei Maruzuru, Jun Arii and Yasushi Kawaguchi
  • Organizer: 42nd Annual International Herpesvirus Workshop
  • Int'l Joint Research
• [Presentation] Herpes simplex 1 UL34 Protein Regurates the Global Architecture of the Endoplasmic Reticulum in Infected Cells (2017)
  • Author(s): Fumio Maeda, Jun Arii, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato and Yasushi Kawaguchi
  • Organizer: 42nd Annual International Herpesvirus Workshop
  • Int'l Joint Research
• [Presentation] Investigation of a novel interaction between the endosomal sorting protein SNX3 and HSV-1 membrane proteins (2016)
  • Author(s): Akihisa Kato, Hayato Harima, Jun Arii, Yasushi Kawaguchi
  • Organizer: 第64回日本ウイルス学会学術集会
  • Place of Presentation: 札幌コンベンションセンター（北海道札幌市）
  • Year and Date: 2016-10-23
• [Presentation] Identification of host factors that mediate HSV-1 nuclear egress (2016)
  • Author(s): Jun Arii, Fumio Maeda, Akihisa Kato, Yasushi Kawaguchi
  • Organizer: 第64回日本ウイルス学会学術集会
  • Place of Presentation: 札幌コンベンションセンター（北海道札幌市）
  • Year and Date: 2016-10-23
• [Presentation] HSV-1 nucleocapsid maturation is regulated by small capsid protein VP26 (2016)
  • Author(s): Ryosuke Kobayashi, Akihisa Kato, Jun Arii, Yasushi Kawaguchi
  • Organizer: 第64回日本ウイルス学会学術集会
  • Place of Presentation: 札幌コンベンションセンター（北海道札幌市）
  • Year and Date: 2016-10-23
• [Presentation] HSV-1 UL34 is required for proper targeting of viral and cellular regulators for viral de-envelopment at the nuclear membrane (2016)
  • Author(s): Fumio Maeda, Yoshitaka Hirohata, Jun Arii, Akihisa Kato, Yasushi Kawaguchi
  • Organizer: 第64回日本ウイルス学会学術集会
  • Place of Presentation: 札幌コンベンションセンター（北海道札幌市）
  • Year and Date: 2016-10-23
• [Presentation] Enzymatic activity of HSV-1 UNG and viral pathogenesis are regulated by its phosphorylation at a specific site (2016)
  • Author(s): Hayato Harima, Akihisa Kato, Mizuki Watanabe, Jun Arii, Yasushi Kawaguchi
  • Organizer: 第64回日本ウイルス学会学術集会
  • Place of Presentation: 札幌コンベンションセンター（北海道札幌市）
  • Year and Date: 2016-10-23
• [Presentation] Herpes simplex virus 1 VP26 is a regulator of nucleocapsid maturation (2016)
  • Author(s): Ryosuke Kobayashi, Akihisa Kato, Jun Arii, Yasushi Kawaguchi
  • Organizer: The 15th Awaji International Forum on Infection and Immunity
  • Place of Presentation: 淡路夢舞台国際会議場（兵庫県淡路市）
  • Year and Date: 2016-09-06
  • Int'l Joint Research
• [Presentation] ヘルペスウイルスnuclear egress complexは、宿主因子を介して核内膜の切断を引き起こす (2016)
  • Author(s): 有井潤, 前田文雄, 加藤哲久, 川口寧
  • Organizer: 第159回日本獣医学会学術集会
  • Place of Presentation: 日本大学生物資源科学部（神奈川県藤沢市）
  • Year and Date: 2016-09-06
• [Presentation] HSV UNG phosphorylation at a specific site regulates its enzymatic activity and viral pathogenesis (2016)
  • Author(s): Hayato Harima, Akihisa Kato, Mizuki Watanabe, Jun Arii, Yasushi Kawaguchi
  • Organizer: 第5回感染症若手フォーラム
  • Place of Presentation: 淡路夢舞台国際会議場（兵庫県淡路市）
  • Year and Date: 2016-09-04
• [Presentation] 単純ヘルペスウイルス１型による小胞体の形態制御 (2016)
  • Author(s): 前田史雄，廣畑吉崇，有井潤，加藤哲久，川口寧
  • Organizer: 第13回ウイルス学キャンプ in 湯河原
  • Place of Presentation: ニューウェルシティ湯河原（静岡県熱海市）
  • Year and Date: 2016-08-30
• [Presentation] Roles of Us8A and its Phosphorylation Mediated by Us3 in Herpes Simplex Virus 1 Pathogenesis (2016)
  • Author(s): Akihisa Kato, Tomoko Ando, Jun Arii, Yasushi Kawaguchi
  • Organizer: 41st Annual International Herpesvirus Workshop
  • Place of Presentation: Monona Terrace Community and Convention Center (Madison, Wisconsin, USA)
  • Year and Date: 2016-07-23
  • Int'l Joint Research
• [Presentation] ESCRT-III mediates HSV-1 Nuclear Egress (2016)
  • Author(s): Jun Arii, Fumio Maeda, Akihisa Kato, Yasushi Kawaguchi
  • Organizer: 41st Annual International Herpesvirus Workshop
  • Place of Presentation: Monona Terrace Community and Convention Center (Madison, Wisconsin, USA)
  • Year and Date: 2016-07-23
  • Int'l Joint Research
• [Presentation] HSV-1 VP26 is a Regulator of Nucleocapsid Maturation (2016)
  • Author(s): Ryosuke Kobayashi, Akihisa Kato, Jun Arii, Yasushi Kawagushi
  • Organizer: 41st Annual International Herpesvirus Workshop
  • Place of Presentation: Monona Terrace Community and Convention Center (Madison, Wisconsin, USA)
  • Year and Date: 2016-07-23
  • Int'l Joint Research
• [Presentation] Endosomal sorting protein SNX3とHSV膜蛋白質の相互作用に関する解析 (2016)
  • Author(s): 加藤哲久, 播磨勇人, 有井潤, 川口寧
  • Organizer: 第30回ヘルペスウイルス研究会
  • Place of Presentation: セミナーハウス クロス・ウェーブ府中（東京都府中市）
  • Year and Date: 2016-06-16
• [Presentation] HSV-1 nuclear egress complex は、宿主因子を介して核内膜の切断を引き起こす (2016)
  • Author(s): 有井潤, 前田史雄, 加藤哲久, 川口寧
  • Organizer: 第30回ヘルペスウイルス研究会
  • Place of Presentation: セミナーハウス クロス・ウェーブ府中（東京都府中市）
  • Year and Date: 2016-06-16
• [Presentation] HSV-1 UL34による小胞媒介性核外輸送関連タンパク質の局在制御 (2016)
  • Author(s): 前田史雄, 廣畑吉崇, 加藤哲久, 有井潤, 川口寧
  • Organizer: 第30回ヘルペスウイルス研究会
  • Place of Presentation: セミナーハウス クロス・ウェーブ府中（東京都府中市）
  • Year and Date: 2016-06-16
• [Presentation] HSV-1 UNGリン酸化の生物学的意義 (2016)
  • Author(s): 播磨勇人, 加藤哲久, 渡邉瑞希, 有井潤, 川口寧
  • Organizer: 第30回ヘルペスウイルス研究会
  • Place of Presentation: セミナーハウス クロス・ウェーブ府中（東京都府中市）
  • Year and Date: 2016-06-16
• [Presentation] HSV-1キャプシドタンパク質VP26はキャプシドの成熟を制御する (2016)
  • Author(s): 小林亮介, 加藤哲久, 有井潤, 川口寧
  • Organizer: 第30回ヘルペスウイルス研究会
  • Place of Presentation: セミナーハウス クロス・ウェーブ府中（東京都府中市）
  • Year and Date: 2016-06-16
• [Presentation] p53はHSV-1の神経病原性に関与する (2016)
  • Author(s): 丸鶴雄平, 小栁直人, 有井潤, 加藤哲久, 川口寧
  • Organizer: 第30回ヘルペスウイルス研究会
  • Place of Presentation: セミナーハウス クロス・ウェーブ府中（東京都府中市）
  • Year and Date: 2016-06-16
• [Presentation] Membrane deformation for HSV-1 secondary envelopment is mediated by its glycoproteins. (2015)
  • Author(s): Jun Arii, Akihisa Kato, Yasuhi Kawaguchi
  • Organizer: 第63回日本ウイルス学会学術集会
  • Place of Presentation: 福岡国際会議場（福岡・福岡）
  • Year and Date: 2015-10-22
• [Presentation] Phosphorylation of an HSV-1 Us8A promotes viral pathogenecity by regulating the ability of the virus to invade the CNS from peripheral sites. (2015)
  • Author(s): Akihisa Kato, Shinya Oda, Jun Arii, Yasushi Kawaguchi
  • Organizer: 第63回日本ウイルス学会学術集会
  • Place of Presentation: 福岡国際会議場（福岡・福岡）
  • Year and Date: 2015-10-22
• [Presentation] RamBP10 acts like HSV-1 ICP0 in regulation of viral gene expression in infected cells. (2015)
  • Author(s): Yuka Sato, Akihisa Kato, Yuhei Maruzuru, Hirohata Yoshitaka, Shumpei Tsuda, Jun Arii, Kawaguchi Yasushi
  • Organizer: 第63回日本ウイルス学会学術集会
  • Place of Presentation: 福岡国際会議場（福岡・福岡）
  • Year and Date: 2015-10-22
• [Presentation] p53 is a critical host regulator of Herpes simplex encephalitis. (2015)
  • Author(s): Yuhei Maruzuru, Naoto Koyanagi, Jun Arii, Akihisa Kato, Yasushi Kawaguchi
  • Organizer: 第63回日本ウイルス学会学術集会
  • Place of Presentation: 福岡国際会議場（福岡・福岡）
  • Year and Date: 2015-10-22
• [Presentation] Herpes simplex virus ICP22 interacts with viral nuclear egress factors UL31, UL34 and Us3, and regulates viral nuclear egress. (2015)
  • Author(s): Yuhei Maruzuru, Keiko Shindo, Zhuoming Liu, MAsaaki Oyama, Hiroko Kozuka-Hata, Jun Arii, Akihisa Kato, Yasushi Kawaguchi
  • Organizer: 第14回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 淡路夢舞台（兵庫・淡路）
  • Year and Date: 2015-09-08
  • Int'l Joint Research
• [Presentation] Functional of the herpes simplex virus 1 small capsid protein VP26 is regulated by phosphorylation at a specific site. (2015)
  • Author(s): Ryosuke Kobayashi, Akihisa Kato, Jun Arii, Yasushi Kawaguchi
  • Organizer: 第14回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 淡路夢舞台（兵庫・淡路）
  • Year and Date: 2015-09-08
  • Int'l Joint Research
• [Presentation] Multiple glycoproteins of herpes simplex virus 1 deform membrane for secondary envelopment. (2015)
  • Author(s): Jun Arii, Akihisa, Yasuhi Kawaguchi
  • Organizer: 第14回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 淡路夢舞台（兵庫・淡路）
  • Year and Date: 2015-09-08
  • Int'l Joint Research
• [Presentation] Phosphorylationof SNX3 induced the protection of HSV-1 protein from (2015)
  • Author(s): Akihisa Kato, Jun Arii, Yasushi Kawaguchi
  • Organizer: 第14回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 淡路夢舞台（兵庫・淡路）
  • Year and Date: 2015-09-08
  • Int'l Joint Research
• [Presentation] RanBP10, a novel cellular protein that interacts with a herpes simplex virus 1 (HSV-1) regulatory protein ICP0, regulates viral gene expression by acting like ICP0 in HSV-1 infected cells. (2015)
  • Author(s): Yuka Sato, Akihisa Kato, Yuhei Maruzuru, Yoshitaka Hirohata, Shumpei Tsuda, Jun arii, Yasushi Kawaguchi
  • Organizer: 第14回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 淡路夢舞台（兵庫・淡路）
  • Year and Date: 2015-09-08
  • Int'l Joint Research
• [Presentation] Down-regulation of a cytokine expression by HSV-1 UL13 protein kinase is critical for herpes encephalitis. (2015)
  • Author(s): Naoto Koyanagi, Takahiro Imai, Keiko Shindo, Jun Arii, Akihisa Kato, Yasushi Kawaguchi
  • Organizer: 第14回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 淡路夢舞台（兵庫・淡路）
  • Year and Date: 2015-09-08
  • Int'l Joint Research
• [Presentation] Role of an interaction between two conserved tegument proteins in herpes simplex virus 1 (HSV-1) replication. (2015)
  • Author(s): Shinya Oda, Akihisa Kato, Jun Arii, Yasushi Kawaguchi
  • Organizer: 第14回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 淡路夢舞台（兵庫・淡路）
  • Year and Date: 2015-09-08
  • Int'l Joint Research
• [Presentation] Elucidationof the type-specific differences in herpes simplex virus Us3 gene. (2015)
  • Author(s): Keiko Shindo, Akihisa Kato, Naoto Koyanagi, Jun Arii, Yasushi Kawaguchi
  • Organizer: 第14回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 淡路夢舞台（兵庫・淡路）
  • Year and Date: 2015-09-08
  • Int'l Joint Research
• [Presentation] Herpes simplex virus 1 recruits CD98 heavy chain and b1 integrin to the nuclear membrane for viral de-envelopment. (2015)
  • Author(s): Yoshitaka Hirohata, Jun Arii, Zhuoming Liu, Keiko Shindo, Masaaki Oyama, hiroko Kozuka-Hata, Hiroshi Sagara, Akihisa Kato, Yasushi Kawaguchi
  • Organizer: 第14回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 淡路夢舞台（兵庫・淡路）
  • Year and Date: 2015-09-08
  • Int'l Joint Research
• [Presentation] Role of host cell protein p32 in herpes simplex virus 1 de-envelopmetn during nuclear egress. (2015)
  • Author(s): Zhuoming Liu, Akihisa Kato, Masaaki Oyama, Hiroko Kozuka-Hata, Jun Arii, Yasushi Kawaguchi
  • Organizer: 第14回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 淡路夢舞台（兵庫・淡路）
  • Year and Date: 2015-09-08
  • Int'l Joint Research
• [Presentation] Herpes simplex virus 1 glycoproteins induce membrane deformation for efficient secondary envelopment. (2015)
  • Author(s): Jun Arii, Akihisa Kato, Yasushi Kawaguchi
  • Organizer: 40th annual international herpesvirus workshop
  • Place of Presentation: Boise (USA)
  • Year and Date: 2015-07-25
  • Int'l Joint Research
• [Presentation] Identification of a host cell protein, RanBP10 which acts like ICP0 in HSV-1 infected cells. (2015)
  • Author(s): Yuka Sato, Akihisa Kato, Yuhei Maruzuru, Yoshitaka Hirohata, Shumpei Tsuda, Jun Arii, Yasushi Kawaguchi
  • Organizer: 40th annual international herpesvirus workshop
  • Place of Presentation: Boise (USA)
  • Year and Date: 2015-07-25
  • Int'l Joint Research
• [Presentation] Elucidation of a critical interaction between the two conseved tegument proteins for HSV-1 secondary envelopment. (2015)
  • Author(s): Shinya Oda, Akihisa Kato, Yuichi Furuhata, Jun Arii, Yasushi Kawaguchi
  • Organizer: 40th annual international herpesvirus workshop
  • Place of Presentation: Boise (USA)
  • Year and Date: 2015-07-25
  • Int'l Joint Research
• [Presentation] HSV-1のウイルス増殖および病態発現はキャプシドタンパク質VP26のリン酸化によって制御される (2015)
  • Author(s): 小林 亮介、加藤 哲久、有井 潤、川口 寧
  • Organizer: 第２９回ヘルペスウイルス研究会
  • Place of Presentation: 長崎にっしょうかん（長崎・長崎）
  • Year and Date: 2015-06-04
• [Presentation] 2型膜タンパク質Us8Aリン酸化の生物学的意義の解明 (2015)
  • Author(s): 加藤 哲久、尾田 信也、有井 潤、川口 寧
  • Organizer: 第２９回ヘルペスウイルス研究会
  • Place of Presentation: 長崎にっしょうかん（長崎・長崎）
  • Year and Date: 2015-06-04
• [Presentation] テグメント蛋白質UL51とUL14は複合体としてHSV-1最終エンベロープ獲得に寄与する (2015)
  • Author(s): 尾田 真也、有井 潤、加藤 哲久、川口 寧
  • Organizer: 第２９回ヘルペスウイルス研究会
  • Place of Presentation: 長崎にっしょうかん（長崎・長崎）
  • Year and Date: 2015-06-04
• [Presentation] HSV-1の糖タンパク質は、膜変性引き起こすことで効率的なsecondary envelopmentに貢献する (2015)
  • Author(s): 有井 潤、加藤 哲久、川口 寧
  • Organizer: 第２９回ヘルペスウイルス研究会
  • Place of Presentation: 長崎にっしょうかん（長崎・長崎）
  • Year and Date: 2015-06-04
• [Presentation] HSV-1感染細胞においてICP0と類似の機能をもつ宿主蛋白質RanBP10の同定 (2015)
  • Author(s): 佐藤 由佳，加藤 哲久，丸鶴 雄平，廣畑 吉崇，津田 峻平，有井 潤，川口 寧
  • Organizer: 第２９回ヘルペスウイルス研究会
  • Place of Presentation: 長崎にっしょうかん（長崎・長崎）
  • Year and Date: 2015-06-04
• [Presentation] ラパトアセッション DNAウイルス (2014)
  • Author(s): 有井潤
  • Organizer: 第62回ウイルス学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川・横浜）
  • Year and Date: 2014-11-10
  • Invited
• [Presentation] HSV-1 gDの細胞内領域に存在するアルギニンクラスターは宿主細胞の膜変性と効率的なエンベロープ獲得に寄与する (2014)
  • Author(s): 有井潤、加藤哲久、川口寧
  • Organizer: 第62回ウイルス学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川・横浜）
  • Year and Date: 2014-11-10
• [Presentation] ヘルペスウイルス科で保存されているHSV-1テグメントタンパク質UL51とUL14の協調的機能の解明 (2014)
  • Author(s): 尾田真也、有井潤、加藤哲久、川口寧
  • Organizer: 第62回ウイルス学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川・横浜）
  • Year and Date: 2014-11-10
• [Presentation] HSV-1キャプシドタンパク質VP26のリン酸化はウイルス増殖および病原性発現に寄与する (2014)
  • Author(s): 小林亮介、加藤哲久、有井潤、川口寧
  • Organizer: 第62回ウイルス学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川・横浜）
  • Year and Date: 2014-11-10
• [Presentation] 中枢神経系における新規HSV-1宿主回避機構の解明：HSV-1プロテインキナーゼUL13はCXCL9の発現を抑制し、中枢神経系へのCD8+T細胞の浸潤を阻害する (2014)
  • Author(s): 小栁直人、今井孝彦、神道慶子、有井潤、加藤哲久、川口寧
  • Organizer: 第62回ウイルス学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川・横浜）
  • Year and Date: 2014-11-10
• [Presentation] 単純ヘルペスウイルス1型感染阻害物質の探索 (2014)
  • Author(s): 前田直良、古川敦、坂本二郎、黒木喜美子、尾瀬農之、垣田浩輔、穴田仁洋、橋本俊一、有井潤、加藤哲久、川口寧、荒瀬尚、前中勝実
  • Organizer: 第62回ウイルス学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川・横浜）
  • Year and Date: 2014-11-10
• [Presentation] 単純ヘルペスウイルス1型テグメントタンパク質UL51とUL14の相互作用 (2014)
  • Author(s): 尾田真也、有井潤、加藤哲久、川口寧
  • Organizer: 第157回日本獣医学会学術集会
  • Place of Presentation: 北海道大学（北海道・札幌）
  • Year and Date: 2014-09-09
• [Presentation] 単純ヘルペスウイルスgDの細胞内領域は、宿主細胞の膜変性と効率的なエンベロープ獲得に寄与する (2014)
  • Author(s): 有井潤、加藤哲久、川口寧
  • Organizer: 第157回日本獣医学会学術集会
  • Place of Presentation: 北海道大学（北海道・札幌）
  • Year and Date: 2014-09-09
• [Presentation] The arginine cluster located at the terminus of the HSV-1 glycoprotein D cytoplasmic domain is required for membrane deformation and for efficient viral secondary envelopment (2014)
  • Author(s): Jun Arii, Akihisa Kato, Yasushi Kawaguchi
  • Organizer: The 39th annual international herpesvirus workshop
  • Place of Presentation: 神戸国際会議場（兵庫・神戸）
  • Year and Date: 2014-07-19
  • Int'l Joint Research
• [Presentation] HSV-1 Us3 phosphorylates sorting necxin 3 to inhibit the lysosomal degradation of glycoprotein D by promoting its interaction with phosphatidylinositol-3-phosphate (2014)
  • Author(s): Akihisa Kato, Jun Arii, Yasushi Kawaguchi
  • Organizer: The 39th annual international herpesvirus workshop
  • Place of Presentation: 神戸国際会議場（兵庫・神戸）
  • Year and Date: 2014-07-19
  • Int'l Joint Research
• [Presentation] HSV-1 recruits CD98hc to the nuclear membrane for fusion between the viral envelopment and the outer nuclear membrane (2014)
  • Author(s): Yoshio Hirohata, Jun Arii, Keiko Shindo, Zhuoming Liu, Masaaki Oyama, Hiroko Kozuka-Hata, Hiroshi Sagara, Akihisa Kato, Yasuhi Kawaguchi
  • Organizer: The 39th annual international herpesvirus workshop
  • Place of Presentation: 神戸国際会議場（兵庫・神戸）
  • Year and Date: 2014-07-19
  • Int'l Joint Research
• [Presentation] The HSV-1 capsid protein VP26 is functionally regulated by phosphorylation in vitro and vivo (2014)
  • Author(s): Ryosuke Kobayashi, Akihisa Kato, Jun Arii, Yasushi Kawaguchi
  • Organizer: The 39th annual international herpesvirus workshop
  • Place of Presentation: 神戸国際会議場（兵庫・神戸）
  • Year and Date: 2014-07-19
  • Int'l Joint Research
• [Presentation] The role of herpes simplex virus 1 immedeate-early protein ICP22 in viral nuclear egress (2014)
  • Author(s): Yuhei Maruzuru, Keiko Shindo, Zhuoming Liu, Masaaki Oyama, Hiroko Kozuka-Hata, Jun Arii, Akihisa Kato, Yasuhi Kawaguchi
  • Organizer: The 39th annual international herpesvirus workshop
  • Place of Presentation: 神戸国際会議場（兵庫・神戸）
  • Year and Date: 2014-07-19
  • Int'l Joint Research
• [Presentation] Characterization of a recombinant chimera HSV-1 in which its Us3 gene is substituted with the HSV-2 Us3 gene (2014)
  • Author(s): Keiko Shindo, Jun Arii, Akihisa Kato, Yasushi Kawaguchi
  • Organizer: The 39th annual international herpesvirus workshop
  • Place of Presentation: 神戸国際会議場（兵庫・神戸）
  • Year and Date: 2014-07-19
  • Int'l Joint Research
• [Presentation] The HSV-1 UL13 protein kinase down-regulates expression of a cytokine to inhibit CD8+ T cell infiltration into the central nervous system (2014)
  • Author(s): Naoto Koyanagi, Takahiko Imai, Keiko Shindo, Jun Arii, Akihisa Kato, Yasushi Kawaguchi
  • Organizer: The 39th annual international herpesvirus workshop
  • Place of Presentation: 神戸国際会議場（兵庫・神戸）
  • Year and Date: 2014-07-19
  • Int'l Joint Research
• [Book] 月刊細胞 2017年12月号 特 集 多様化する感染症研究 ウイルスとヒトとの共生関係 (2017)
  • Author(s): 有井 潤、川口 寧
  • Total Pages: 3
  • Publisher: ニューサイエンス社
• [Remarks] 研究室のホームページ
  • URL: http://www.ims.u-tokyo.ac.jp/kawaguchi-lab/KawaguchiLabTop.html
• [Remarks] 研究成果のプレスリリース
  • URL: http://www.ims.u-tokyo.ac.jp/imsut/jp/research/papers/post_98.php
• [Remarks] 所属研究室のホームページ
  • URL: http://www.ims.u-tokyo.ac.jp/kawaguchi-lab/publications.html