Studies on entry and nuclear egress of Herpes Simplex Virus
| Project/Area Number |
26713017
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Arii Jun 東京大学, 医科学研究所, 助教 (30704928)
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| Research Collaborator |
KAWAGUCHI Yasushi 東京大学, 医科学研究所, 教授
KATO Akihisa 東京大学, 医科学研究所, 助教
KOYANAGI Naoto 東京大学, 医科学研究所, 特任研究員
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2016: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2015: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2014: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | HSV / 糖タンパク質 / 膜タンパク質 / 核膜 / 細胞膜 / ウイルス粒子形成 / ウイルス侵入 / 粒子形成 / 核膜通過 / glycoprotein / ウイルス / レセプター / 粒子形成過程 / エントリー |
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| Outline of Final Research Achievements |
We investigated the mechanism by which HSV passes though cellular membranes. We successfully identified several viral or cellular factors which promote passage through cellular membranes of HSV. As these steps are essential for viral life cycle, our results may indicate new prophylactic and therapeutic approaches for the development of antiherpetic drugs.
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Report
(5 results)
Research Products
(100 results)
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[Journal Article] Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication.2018
Author(s)
Maruzuru Y, Ichinohe T, Sato R, Miyake K, Okano T, Suzuki T, Koshiba T, Koyanagi N, Tsuda S, Watanabe M, Arii J, Kato A, Kawaguchi Y.
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Journal Title
Cell Host Microbe.
Volume: 23
Issue: 2
Pages: 254-265
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Herpes simplex virus-1 evasion of CD8+ T cell accumulation contributes to viral encephalitis.2017
Author(s)
Koyanagi N, Imai T, Shindo K, Sato A, Fujii W, Ichinohe T, Takemura N, Kakuta S, Uematsu S, Kiyono H, Maruzuru Y, Arii J, Kato A, Kawaguchi Y.
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Journal Title
J Clin Invest.
Volume: 127
Issue: 10
Pages: 3784-3795
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] ESCRT-III mediates HSV-1 Nuclear Egress2016
Author(s)
Jun Arii, Fumio Maeda, Akihisa Kato, Yasushi Kawaguchi
Organizer
41st Annual International Herpesvirus Workshop
Place of Presentation
Monona Terrace Community and Convention Center (Madison, Wisconsin, USA)
Year and Date
2016-07-23
Related Report
Int'l Joint Research
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