| Budget Amount *help |
¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2016: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2015: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2014: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Outline of Final Research Achievements |
By classifying Treg precursor cells according to their developmental stages, we revealed Treg cell developmental programs which are dependent on Nr4a factors, as well as programs that are independent of Nr4a factors. In the analysis, we further elucidated that Nr4a factors act at relatively later stages in Treg cell development. Foxp3, that were induced by Nr4a factors then found to induce Nr4a factors, thus forming a positive feedback loop, sustaining Treg cell development.Furthermore, Nr4a-deficient Treg precursor cells not only complete their development to Treg cells, but they survive with an attenuated expression of apoptotic factors including Bim, thus converting to helper-T like cells with elevated expression of inflammatory cytokines that are usually not to be expressed by Treg cells but by helper T cells.
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