Development of inspection method for diagnostic disease border condition states of human lifestyle related disease using human fingernails and application to the prevention.
Project/Area Number |
26713021
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Partial Multi-year Fund |
Research Field |
Laboratory medicine
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Research Institution | University of Shizuoka |
Principal Investigator |
Min Junzhe 静岡県立大学, 薬学部, 講師 (10453060)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2016: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2015: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2014: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
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Keywords | ヒト爪 / 生活習慣病 / 境界病態検査 / 糖尿病 / 痛風 / 大腸癌 / 早期予防 / 質量分析 / 質量分析計 / 境界病態 / 早期診断 / 非侵襲的 |
Outline of Final Research Achievements |
We inspected advantages and the possibility of using human fingernail as the new clinical bio sample for the diagnostic lifestyle related disease border condition of diabetes, gout and colorectal cancer. As a result of detecting D,L-Ala, D,L-Val, D,L-Leu in the fingernail of healthy volunteers, person of border hyperglycosemia and diabetes, and having made a statistical analysis; in the ratio of the peak area of D/L-Ala a healthy volunteers and a person of border hyperglycosemia, significant difference (p <0.01) was accepted among diabetics with healthy volunteers. In addition, when comparing the index from the healthy volunteers with that from the gout patient, the uric acid level was higher in the gout patient. A statistically significant correlation was observed with the uric acid (p <0.01). Therefore, noninvasive human fingernail, usefulness is suggested as a new bio sample of the lifestyle related disease diagnosis including diabetes, gout and colorectal cancer.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Human nails metabolite analysis: A rapid and simple method for quantification of uric acid in human fingernail by high-performanceliquid chromatography with UV-detection2015
Author(s)
Xi-Ling Li, Gao Li, Ying-Zi Jiang, Dongzhou Kang, Cheng Hua Jin, Qing Shi,Toufeng Jin, Koichi Inoue, Kenichiro Todoroki, Toshimasa Toyo'oka, Jun Zhe Min
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Journal Title
Journal of Chromatography B
Volume: 1002
Pages: 394-398
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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