| Budget Amount *help |
¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2016: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2015: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2014: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
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| Outline of Final Research Achievements |
We inspected advantages and the possibility of using human fingernail as the new clinical bio sample for the diagnostic lifestyle related disease border condition of diabetes, gout and colorectal cancer. As a result of detecting D,L-Ala, D,L-Val, D,L-Leu in the fingernail of healthy volunteers, person of border hyperglycosemia and diabetes, and having made a statistical analysis; in the ratio of the peak area of D/L-Ala a healthy volunteers and a person of border hyperglycosemia, significant difference (p <0.01) was accepted among diabetics with healthy volunteers. In addition, when comparing the index from the healthy volunteers with that from the gout patient, the uric acid level was higher in the gout patient. A statistically significant correlation was observed with the uric acid (p <0.01). Therefore, noninvasive human fingernail, usefulness is suggested as a new bio sample of the lifestyle related disease diagnosis including diabetes, gout and colorectal cancer.
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