| Project/Area Number |
26713022
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Medical Physics and Radiological Technology
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| Research Institution | National Cancer Center Japan |
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Principal Investigator |
Tachibana Hidenobu 国立研究開発法人国立がん研究センター, 先端医療開発センター, 医学物理専門職 (20450215)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | 追尾照射 / 四次元CT / DIR / CT pulmonary ventilation / Quality assurance / 四次元 / 堅牢性 / 肺機能画像 / 患者体位変化管理 |
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| Outline of Final Research Achievements |
To investigate a weighted four-dimensional (W-4D) treatment planning strategy based on the greater clinical advantage of the conformal over the intensity-modulated technique in lung stereotactic body radiotherapy (SBRT). W-4D was evaluated in eighteen lung SBRT patients.The W-4D plan’s key concept was to escalate (or reduce) fluence using a 4D optimization algorithm when the tumour target was out-of-line (or in-line) with an organ-at-risk. The fluence was converted to a dynamic multi-leaf collimator leaf sequence for deliverable 4D irradiation. In all patients, the W-4D plan enabled planning tumour volume conformity comparable to the conventional 4D plan. The W-4D is a robust, practical planning approach that achieves significant dose sparing relative to non-time-resolved tracking; it may be of greater clinical benefit in radiotherapy than the spatially intensity-modulated 4D approach.
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