Unraveling the mechanisms of exercise-mimicking adiponectin receptor signaling
| Project/Area Number |
26713032
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Masato Iwabu 東京大学, 医学部附属病院, 特任准教授 (30557236)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2014: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
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| Keywords | 糖尿病 / シグナル伝達 / アディポネクチン |
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| Outline of Final Research Achievements |
So far, we have shown that the dramatic upsurge of type 2 diabetes responsible for cardiovascular disease as the leading cause of mortality in Japan is primarily accounted for by the decreased action of adiponectin/adiponectin receptor (AdipoR) signaling and that adiponectin/AdipoR1 are involved in the regulation of mitochondrial functions and exert exercise-mimicking effects in the skeletal muscle. In the process, our research has been instrumental in unraveling potential mechanisms involved in AMPK activation by adiponectin/AdipoR1 through successful conformational analysis of the AdipoRs but also in identifying novel key molecules involved in exercise-mimicking adiponectin/AdipoR1 signaling, thereby unraveling a novel mechanism of metabolic regulation involving AdipoR1.
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Report
(4 results)
Research Products
(56 results)
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[Journal Article] Crystal structures of the human adiponectin receptors.2015
Author(s)
Tanabe H, Fujii Y, Okada-Iwabu M, Iwabu M, Nakamura Y, Hosaka T, Motoyama K, Ikeda M, Wakiyama M, Terada T, Ohsawa N, Hato M, Ogasawara S, Hino T, Murata T, Iwata S, Hirata K, Kawano Y, Yamamoto M, Kimura-Someya T, Shirouzu M, Yamauchi T, Kadowaki T, Yokoyama S
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Journal Title
Nature
Volume: 520
Issue: 7547
Pages: 312-316
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] A Novel Peroxisome Proliferator-activated Receptor (PPAR)α Agonist and PPARγ Antagonist, Z-551, Ameliorates High-fat Diet-induced Obesity and Metabolic Disorders in Mice.2015
Author(s)
Shiomi Y, Yamauchi T, Iwabu M, Okada-Iwabu M, Nakayama R, Orikawa Y, Yoshioka Y, Tanaka K, Ueki K, Kadowaki T
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Journal Title
J Biol Chem
Volume: 290
Issue: 23
Pages: 14567-14581
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Expression, purification, crystallization, and preliminary X-ray crystallographic studies of the human adiponectin receptors, AdipoRl and AdipoR22015
Author(s)
Tanabe H,..., Iwata S, Okada-Iwabu M, Iwabu M,..., Yamauchi T, Kadowaki T, and Yokoyama S
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Journal Title
J. Struct. Funct. Genomics
Volume: 16
Issue: 1
Pages: 11-23
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 腸内細菌と代謝疾患2015
Author(s)
岩部 真人、山内 敏正、岩部 美紀、門脇 孝
Organizer
第36回 日本炎症・再生医学会
Place of Presentation
虎ノ門ヒルズフォーラム（東京都港区）
Year and Date
2015-07-21
Related Report
Invited
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[Book] 月刊糖尿病2014
Author(s)
岩部 真人, 山内 敏正, 門脇 孝
Total Pages
140
Publisher
医学出版
Related Report
