| Budget Amount *help |
¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2014: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
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| Outline of Final Research Achievements |
So far, we have shown that the dramatic upsurge of type 2 diabetes responsible for cardiovascular disease as the leading cause of mortality in Japan is primarily accounted for by the decreased action of adiponectin/adiponectin receptor (AdipoR) signaling and that adiponectin/AdipoR1 are involved in the regulation of mitochondrial functions and exert exercise-mimicking effects in the skeletal muscle. In the process, our research has been instrumental in unraveling potential mechanisms involved in AMPK activation by adiponectin/AdipoR1 through successful conformational analysis of the AdipoRs but also in identifying novel key molecules involved in exercise-mimicking adiponectin/AdipoR1 signaling, thereby unraveling a novel mechanism of metabolic regulation involving AdipoR1.
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