Approaches to control in vivo dynamics of nanoparticle carriers for diagnosis and therapy in nuclear medicinal fields
| Project/Area Number |
26713040
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | University of Fukui |
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Principal Investigator |
MAKINO Akira 福井大学, 高エネルギー医学研究センター, 准教授 (00566226)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
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| Keywords | ナノ粒子 / 核医学イメージング / 内照射治療 / PET / ナノ材料 / 放射線 |
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| Outline of Final Research Achievements |
For the development of the image-based therapy using nanoparticle carriers, shortening the waiting time from the probe dosage to the imaging, and reduction of non-specific radiation exposures caused by RI labeled nanoparticle circulating blood is important issues.
In this study, we investigated a method to forcibly remove nanoparticles circulating in blood. Using anti-nanoparticle antibody, we succeeded in greatly reducing the nanoparticle in blood, which causes for the undesired background signal on imaging. Additionally, we also developed nanoparticle type drug for internal radiation therapy using Auger electron emission nuclide with short radiation range, which is expected to be able to suppress nonspecific exposure.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Inflammation-induced synergetic enhancement of nanoparticle treatments with DOXIL and 90Y-Lactosome for orthotopic mammary tumor2016
Author(s)
Kensuke Kurihara, Motoki Ueda, Isao Hara, Eri Hara, Kohei Sano, Akira Makino, Eiichi Ozeki, Fumihiko Yamamoto, Hideo Saji, Kaori Togashi, Shunsaku Kimura
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Journal Title
Journal of Nanoparticle Research
Volume: 18
Issue: 5
Pages: 137-137
DOI
Related Report
Peer Reviewed
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