| Budget Amount *help |
¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2016: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
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| Outline of Final Research Achievements |
For the development of the image-based therapy using nanoparticle carriers, shortening the waiting time from the probe dosage to the imaging, and reduction of non-specific radiation exposures caused by RI labeled nanoparticle circulating blood is important issues.
In this study, we investigated a method to forcibly remove nanoparticles circulating in blood. Using anti-nanoparticle antibody, we succeeded in greatly reducing the nanoparticle in blood, which causes for the undesired background signal on imaging. Additionally, we also developed nanoparticle type drug for internal radiation therapy using Auger electron emission nuclide with short radiation range, which is expected to be able to suppress nonspecific exposure.
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