Uterus transplantation research with cynomolgus monkeys and survey of attitudes toward uterus translpantion
| Project/Area Number |
26713050
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
Kisu Iori 慶應義塾大学, 医学部, 特任助教 (30445267)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥21,710,000 (Direct Cost: ¥16,700,000、Indirect Cost: ¥5,010,000)
Fiscal Year 2015: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2014: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
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| Keywords | 生殖医学 |
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| Outline of Final Research Achievements |
We performed uterus allo-transplantaion with cynomolgus monkeys. Establishments of surgical procedure, protocol of immunosupressants and rejection diagnosis were examined in this study. The allowable warm ischemic time was examined and it was figured out that four hours was acceptable in cynomolgus monkeys, but the uterus which kept ischmemia for 8 hours was atrophied.
Moreover, surveys of attitudes toward uterus transplantaion was performed with internet web-site. Our results suggest that many Japanese women of reproductive age feel that UTx is socially and individually acceptable, but that concerns requiring further discussion remain among these women. There was also a tendency for UTx to be viewed more favorably than gestational surrogacy.
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] Organ perfusion for uterus transplantation in non-human primates with assumed procurement of a uterus from a brain-dead donor.2016
Author(s)
Kisu I, Kato Y, Yamada Y, Matsubara K, Obara H, Emoto K, Adachi M, Umene K, Nogami Y, Banno K, Kitagawa Y, Aoki D.
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Journal Title
Transplant Proc.
Volume: 未定
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Study of pharmacokinetic properties of cyclosporine A after subcutaneous injection in cynomolgus monkey.2015
Author(s)
Kisu I, Kato Y, Tsuchiya H, Kawamoto I, Nakagawa T, Ogasawara K, Hayakawa T, Yamayoshi Y, Iketan O, Mihara M, Banno K, Sato S, Shiina T, Aoki D.
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Journal Title
International Journal of Pharmacology
Volume: 10
Pages: 487-493
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] 子宮移植の現状について2014
Author(s)
木須伊織
Organizer
第39回日本外科系連合学会学術集会
Place of Presentation
日本教育会館（東京都千代田区）
Year and Date
2014-06-20
Related Report
Invited
