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Uterus transplantation research with cynomolgus monkeys and survey of attitudes toward uterus translpantion

Research Project

Project/Area Number 26713050
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Obstetrics and gynecology
Research InstitutionKeio University

Principal Investigator

Kisu Iori  慶應義塾大学, 医学部, 特任助教 (30445267)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥21,710,000 (Direct Cost: ¥16,700,000、Indirect Cost: ¥5,010,000)
Fiscal Year 2015: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2014: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Keywords生殖医学
Outline of Final Research Achievements

We performed uterus allo-transplantaion with cynomolgus monkeys. Establishments of surgical procedure, protocol of immunosupressants and rejection diagnosis were examined in this study. The allowable warm ischemic time was examined and it was figured out that four hours was acceptable in cynomolgus monkeys, but the uterus which kept ischmemia for 8 hours was atrophied.
Moreover, surveys of attitudes toward uterus transplantaion was performed with internet web-site. Our results suggest that many Japanese women of reproductive age feel that UTx is socially and individually acceptable, but that concerns requiring further discussion remain among these women. There was also a tendency for UTx to be viewed more favorably than gestational surrogacy.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • Research Products

    (29 results)

All 2016 2015 2014

All Journal Article (12 results) (of which Peer Reviewed: 9 results,  Acknowledgement Compliant: 3 results) Presentation (17 results) (of which Int'l Joint Research: 1 results,  Invited: 11 results)

  • [Journal Article] Organ perfusion for uterus transplantation in non-human primates with assumed procurement of a uterus from a brain-dead donor.2016

    • Author(s)
      Kisu I, Kato Y, Yamada Y, Matsubara K, Obara H, Emoto K, Adachi M, Umene K, Nogami Y, Banno K, Kitagawa Y, Aoki D.
    • Journal Title

      Transplant Proc.

      Volume: 未定

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 子宮移植の現状と将来の展望2016

    • Author(s)
      木須伊織
    • Journal Title

      日本IVF学会雑誌

      Volume: 未定

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 子宮移植の現状、課題、展望2016

    • Author(s)
      木須伊織
    • Journal Title

      臨床評価

      Volume: 未定

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Study of pharmacokinetic properties of cyclosporine A after subcutaneous injection in cynomolgus monkey.2015

    • Author(s)
      Kisu I, Kato Y, Tsuchiya H, Kawamoto I, Nakagawa T, Ogasawara K, Hayakawa T, Yamayoshi Y, Iketan O, Mihara M, Banno K, Sato S, Shiina T, Aoki D.
    • Journal Title

      International Journal of Pharmacology

      Volume: 10 Pages: 487-493

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A surgical technique using the ovarian vein in non-human primate models of potential living-donor surgery of uterus transplantation.2015

    • Author(s)
      Kisu I, Banno K, Mihara M, Hara H, Umene K, Adachi M, Nogami Y, Aoki D.
    • Journal Title

      Acta Obstet Gynecol Scand.

      Volume: 94 Issue: 9 Pages: 942-948

    • DOI

      10.1111/aogs.12701

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] トピックス 子宮移植の現況2015

    • Author(s)
      木須伊織
    • Journal Title

      日本生殖内分泌学会雑誌

      Volume: 20 Pages: 59-62

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 「世界の医学誌から」子宮移植後の生児出産(解説)2015

    • Author(s)
      木須伊織、青木大輔
    • Journal Title

      MMJ (The Mainichi Medical Journal)

      Volume: 11 Pages: 280-281

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 子宮移植研究の現況と将来の展望2015

    • Author(s)
      木須伊織
    • Journal Title

      今日の移植

      Volume: 28 Pages: 149-155

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] カニクイザルを用いた子宮移植モデルの開発2015

    • Author(s)
      木須伊織
    • Journal Title

      SPDP LETTETRS

      Volume: 13 Pages: 1-4

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 子宮移植 ~臨床応用を目指して~2014

    • Author(s)
      木須伊織、阪埜浩司
    • Journal Title

      医学の歩み

      Volume: 249 Pages: 55-60

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 子宮移植の現状~子宮性不妊患者に対する妊孕性再建技術の可能性~2014

    • Author(s)
      木須伊織, 阪埜浩司, 安達将隆, 梅根紀代子, 青木大輔
    • Journal Title

      日本婦人科腫瘍学会雑誌

      Volume: 32 Pages: 135-141

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 子宮悪性腫瘍患者に対する子宮移植の展望2014

    • Author(s)
      木須伊織, 阪埜浩司, 安達将隆, 梅根紀代子, 青木大輔
    • Journal Title

      産科と婦人科

      Volume: 81 Pages: 1243-1248

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] 子宮移植の現状と今後の展望2016

    • Author(s)
      木須伊織
    • Organizer
      第5回ASAN Friendship Meeting
    • Place of Presentation
      虎の門ヒルズ森タワー(東京都千代田区)
    • Year and Date
      2016-02-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Uterus transplantation research in Japan2016

    • Author(s)
      Iori Kisu, Nobuhiko Suganuma
    • Organizer
      International Society for Uterus Transplantation (ISUTx)
    • Place of Presentation
      イエテボリ(スウェーデン)
    • Year and Date
      2016-01-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 子宮移植の現状と我々の取り組み2015

    • Author(s)
      木須伊織
    • Organizer
      第4回日本子宮移植研究会学術集会・市民公開講座
    • Place of Presentation
      ベルサール飯田橋駅前(東京都千代田区)
    • Year and Date
      2015-11-03
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 我が国における若年女性の子宮移植に対する意識調査結果2015

    • Author(s)
      木須伊織
    • Organizer
      第4回日本子宮移植研究会学術集会・市民公開講座
    • Place of Presentation
      ベルサール飯田橋駅前(東京都千代田区)
    • Year and Date
      2015-11-03
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 子宮移植は新たな臓器移植医療となり得るか?-子宮移植研究の現況と展望-2015

    • Author(s)
      木須伊織, 阪埜浩司, 加藤容二郎, 山田洋平, 松原健太郎, 篠田昌宏, 尾原秀明, 北川雄光,青木大輔
    • Organizer
      第51回日本移植学会総会
    • Place of Presentation
      ホテル日航熊本(熊本県熊本市)
    • Year and Date
      2015-10-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 子宮移植の現状と将来の展望2015

    • Author(s)
      木須伊織
    • Organizer
      第18回IVF学会
    • Place of Presentation
      アクロス福岡(福岡県福岡市)
    • Year and Date
      2015-09-27
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 子宮移植の現状と今後の展望2015

    • Author(s)
      木須伊織
    • Organizer
      第3回臓器移植フォーラム
    • Place of Presentation
      北里講堂(東京都新宿区)
    • Year and Date
      2015-09-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Organ perfusion technique for uterus transplant and allotransplant in non-human primates under assumption of the procurement of a uterus from a brain-dead donor2015

    • Author(s)
      Iori Kisu
    • Organizer
      the 14th Congress of the Asian Society of Transplantation
    • Place of Presentation
      Suntec Singapore Convention & Exhibition Centre(シンガポール)
    • Year and Date
      2015-08-23 – 2015-08-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非ヒト霊長類動物における脳死ドナーを想定した子宮移植の臓器灌流手技および同種移植の経験2015

    • Author(s)
      木須伊織
    • Organizer
      第57回日本婦人科腫瘍学会
    • Place of Presentation
      いわて県民情報交流センター(岩手県盛岡市)
    • Year and Date
      2015-08-07 – 2015-08-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 「子宮移植の臨床的展開」産婦人科医療の視点から2015

    • Author(s)
      木須伊織
    • Organizer
      第60回日本生殖医学会学術講演会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-04-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 非ヒト霊長類動物による低侵襲手術を目指した子宮移植ドナー手術技術の開発2015

    • Author(s)
      木須伊織, 阪埜浩司, 梅根紀代子, 安達将隆, 野上侑哉, 三原 誠, 原 尚子, 菅沼信彦, 田中 守, 青木大輔
    • Organizer
      第65回日本産科婦人科学会総会・学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-04-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] A preliminary allogeneic uterine transplantation study in non-human primates models2014

    • Author(s)
      Iori Kisu, Kouji Banno, Masataka Adachi, Kiyoko Umene, Daisuke Aoki
    • Organizer
      15th Biennial Meeting of the International Gynecologic Cancer Society
    • Place of Presentation
      Melbourne Convention Exhibition Centre(オーストラリア・メルボルン)
    • Year and Date
      2014-11-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 子宮移植研究の現状と将来の展望2014

    • Author(s)
      木須伊織
    • Organizer
      日本移植支援協会 第15回全国臓器移植支援の会代表者の集い
    • Place of Presentation
      五反田ゆーぽーと(東京都品川区)
    • Year and Date
      2014-10-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 子宮移植は可能か?-子宮性不妊女性に対する子宮移植研究の現況と将来の展望-2014

    • Author(s)
      木須伊織
    • Organizer
      第63回共済医学会
    • Place of Presentation
      名古屋マリオットアソシアホテル(愛媛県名古屋市)
    • Year and Date
      2014-10-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非ヒト霊長類動物モデルを用いた子宮移植モデルの開発 ~子宮性不妊患者に対する妊孕性再建技術の可能性を探って~2014

    • Author(s)
      木須伊織, 三原 誠, 原 尚子, 飯田拓也, 梅根紀代子, 安達将隆, 阪埜浩司, 菅沼信彦, 青木大輔
    • Organizer
      第17回日本IVF学会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2014-09-14 – 2014-09-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] 子宮移植研究の現況と将来の展望2014

    • Author(s)
      木須伊織
    • Organizer
      第50回日本移植学会総会
    • Place of Presentation
      京王プラザ(東京都新宿区)
    • Year and Date
      2014-09-10 – 2014-09-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 子宮移植の現状について2014

    • Author(s)
      木須伊織
    • Organizer
      第39回日本外科系連合学会学術集会
    • Place of Presentation
      日本教育会館(東京都千代田区)
    • Year and Date
      2014-06-20
    • Related Report
      2014 Annual Research Report
    • Invited

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Published: 2014-04-04   Modified: 2017-05-10  

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