| Budget Amount *help |
¥23,140,000 (Direct Cost: ¥17,800,000、Indirect Cost: ¥5,340,000)
Fiscal Year 2017: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2016: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
This project revealed the cause of diabetic wound chronic inflammation and the major factor responsible for its mechanism. In addition, the applicant established a newly founded ex vivo expansion system which enhances the function of diabetic peripheral blood mononuclear cells that can be effective for diabetic wound healing by changing the inflammatory wound environment to anti-inflammatory regenerative state. These findings have built the bases for establishing highly effective cell therapy for diabetic wound healing. Furthermore, the treatment predictor bio-marker candidates for cell therapy found in this study will lead us to establishing personalized treatment strategies according to gene characteristics.
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