| Budget Amount *help |
¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2014: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
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| Outline of Final Research Achievements |
Tissues and cells are coordinated and remodeled to adapt to various environmental situations by sensing and transducing the signals induced by mechanical stress. It is well known that the human body homeostasis cannot maintain in the condition of microgravity. In this study, from the transcriptomic screening and functional analysis, we identified the immunoregulatory factors expressed in locomotor system induced by mechanical loading/unloading and analyzed conditional knockout mice in which these factors are deleted in skeletal muscle and/or osteocytes.
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