Homeostatic interaction between locomotor and immune system induced with mechanical stress
| Project/Area Number |
26713052
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Hayashi Mikihito 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (50581914)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2014: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
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| Keywords | メカニカルストレス / 骨細胞 / 運動器 / ストレス / 免疫学 / シグナル伝達 |
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| Outline of Final Research Achievements |
Tissues and cells are coordinated and remodeled to adapt to various environmental situations by sensing and transducing the signals induced by mechanical stress. It is well known that the human body homeostasis cannot maintain in the condition of microgravity. In this study, from the transcriptomic screening and functional analysis, we identified the immunoregulatory factors expressed in locomotor system induced by mechanical loading/unloading and analyzed conditional knockout mice in which these factors are deleted in skeletal muscle and/or osteocytes.
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Report
(4 results)
Research Products
(6 results)
