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The effects of mastication on brain function and whole body function: using non-invasive measurement of human brain function

Research Project

Project/Area Number 26713055
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Orthodontics/Pediatric dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

MIYAMOTO Jun  東京医科歯科大学, 歯学部附属病院, 助教 (10451949)

Research Collaborator MORIYAMA Keiji  
HONDA Manabu  
HANAKAWA Takashi  
Project Period (FY) 2014-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Fiscal Year 2017: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywords咀嚼 / 口腔 / 脳機能 / 歯学
Outline of Final Research Achievements

Investigation of the influence of chewing stimulation on the higher central feeding regulatory system: Attentional bias to food in hunger condition after fasting were analyzed by measuring reaction time to food images and eye movements before and after the following three tasks; chewing on odorless and tasteless gum, actual feeding and no chewing/feeding. Reaction time and eye movement changed significantly before and after chewing on odorless gum and actual feeding, showing a decrease in attentional bias to food. However, no significant differences were found before and after no chewing/feeding.
Elucidation of the difference in neural mechanism involved in masticatory movement between incisal/molar biting: When biting with incisors/molars only, fMRI-electromyogram were measured simultaneously to examine differences in brain activation patterns. The correlation between brain activation and masticatory muscle activity showed reciprocal patterns between incisor/molar teeth biting.

Academic Significance and Societal Importance of the Research Achievements

咀嚼が高次中枢摂食調節機構に与える影響の解明:味や匂い、食事摂取なしでも、(ガム)咀嚼刺激が食欲抑制効果を発揮しうることを実証し、咀嚼は衝動的な摂食行動を防ぐことに寄与する可能性が示唆され、咀嚼運動を促すことが過食に対する効果的な予防法となり得ることが推察された。
前歯/臼歯部咬合の違いによる咀嚼運動時の神経機構の同定:前歯/臼歯部咀嚼時の脳賦活パタンが異なることを実証し、前歯/臼歯部の役割の違いについて、解剖学的形態の違いに基づいた説明のみならず、脳における咀嚼運動制御機構の違いから説明することができると思われる。また、咀嚼機能の低下が中枢に与える影響を、解明する一助となりうると考えられる。

Report

(6 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (27 results)

All 2018 2017 2016 2015 2014

All Journal Article (9 results) (of which Peer Reviewed: 8 results,  Open Access: 6 results,  Acknowledgement Compliant: 2 results) Presentation (18 results) (of which Int'l Joint Research: 7 results)

  • [Journal Article] Chewing Stimulation Reduces Appetite Ratings and Attentional Bias toward Visual Food Stimuli in Healthy-Weight Individuals2018

    • Author(s)
      Ikeda Akitsu、Miyamoto Jun J.、Usui Nobuo、Taira Masato、Moriyama Keiji
    • Journal Title

      Frontiers in Psychology

      Volume: 9

    • DOI

      10.3389/fpsyg.2018.00099

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of EMG activity and blood flow during graded exertion in the orbicularis oris muscle of adult subjects with and without lip incompetence: a cross-sectional survey.2018

    • Author(s)
      Takada J, Miyamoto JJ, Sato C, Dei A, Moriyama K.
    • Journal Title

      European Journal of Orthodontics.

      Volume: 40(3) Pages: 304-311

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] New application of dynamic magnetic resonance imaging for the assessment of deglutitive tongue movement.2018

    • Author(s)
      Ekprachayakoon I, Miyamoto JJ, Inoue-Arai MS, Honda EI, Takada JI, Kurabayashi T, Moriyama K.
    • Journal Title

      Progress in Orthodontics.

      Volume: 19(1) Issue: 1 Pages: 45-45

    • DOI

      10.1186/s40510-018-0245-x

    • NAID

      120007029982

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 咀嚼が食欲制御機構に与える影響2018

    • Author(s)
      池田安紀津, 宮本順, 臼井信男, 泰羅雅登, 森山啓司.
    • Journal Title

      口腔病学会雑誌

      Volume: 85(2) Pages: 69-69

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Association between 3-dimensional mandibular morphology and condylar movement in subjects with mandibular asymmetry.2017

    • Author(s)
      Ikeda M, Miyamoto JJ, Takada JI, Moriyama K.
    • Journal Title

      Am J Orthod Dentofacial Orthop

      Volume: 482 Issue: 2 Pages: 324-334

    • DOI

      10.1016/j.ajodo.2016.06.042

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of blood flow and electromyographic activity in the perioral muscles.2016

    • Author(s)
      Dei, A., Miyamoto, J.J., Takada, JI., Ono, T. Moriyama, K.
    • Journal Title

      Eur J Orthod.

      Volume: なし Issue: 5 Pages: 525-531

    • DOI

      10.1093/ejo/cjv079

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Noonan症候群患者における顎顔面形態および口腔内の特徴についての検討2015

    • Author(s)
      植野智子、宮本順、片岡恵一、佐藤麻緒、馬場祥行、金田一純子、森山啓司.
    • Journal Title

      Orthodontic Waves- Japanese Edition

      Volume: 74(2) Pages: 86-99

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Noonan症候群患者における頭蓋底および頚部の特徴についての検討2015

    • Author(s)
      薮中友絵、宮本順、片岡恵一、佐藤麻緒、馬場祥行、金田一純子、森山啓司.
    • Journal Title

      Orthodontic Waves- Japanese Edition

      Volume: 74(2) Pages: 100-110

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the mandibular hinge axis in adult patients with facial asymmetry with and without posterior unilateral crossbite2015

    • Author(s)
      Jun-ichi Takada, Jun J Miyamoto, Toshiaki Yokota, Takashi Ono, Keiji Moriyama
    • Journal Title

      European Journal of Orthodontics

      Volume: 37 Issue: 1 Pages: 22-27

    • DOI

      10.1093/ejo/cju009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 前歯・臼歯咬合時の高次中枢における咀嚼運動制御機構の検討.2018

    • Author(s)
      吉澤英之、宮本順、花川隆、本田学、森山啓司.
    • Organizer
      第77回日本矯正歯科学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 下顎骨体部骨切り術を併用した下顎枝矢状分割術を施行し下顎左方偏位を改善した陳旧性下顎骨骨折症例の三次元形態および機能的評価.2018

    • Author(s)
      宮本順、小倉健司、山崎安晴、森山啓司.
    • Organizer
      第77回東京矯正歯科学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Electromyographic activity and blood flow during graded exertion in the orbicularis oris muscle of adult subjects with and without lip incompetence.2018

    • Author(s)
      Takada J, Miyamoto JJ, Sato C, Dei A, Moriyama K.
    • Organizer
      94th European Orthodontic Society Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 咀嚼が食欲制御機構に与える影響-食物関連視覚刺激を用いた認知心理学的研究-.2017

    • Author(s)
      池田安紀津、宮本順、臼井信男、泰羅雅登、森山啓司.
    • Organizer
      第76回日本矯正歯科学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 思春期性成長後期に上顎骨延長法を適応した片側性口唇口蓋裂の一例.2017

    • Author(s)
      宮本順、田村明日香、小倉健司、小川卓也、森田圭一、森山啓司.
    • Organizer
      第41回日本口蓋裂学会総会・学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Effect of mastication on satiety using an attentional bias task.2016

    • Author(s)
      Ikeda A, Miyamoto JJ, Usui N, Taira M, Moriyama K.
    • Organizer
      94th General Session & Exhibition of International Association for Dental Research
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical study of Japanese Marfan syndrome patients: craniofacial morphology.2016

    • Author(s)
      Arimura M, Komazaki Y, Miyamoto JJ, Ogura K, Kobayashi Y, Moriyama K.
    • Organizer
      The 49th Annual Scientific Congress, Korean Association of Orthodontists
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical study of Marfan syndrome patients: intraoral characteristics.2016

    • Author(s)
      Akiyama S, Ogura K, Miyamoto JJ, Komazaki Y, Takada J, Moriyama K
    • Organizer
      The 49th Annual Scientific Congress, Korean Association of Orthodontists
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Maxillofacial morphology of 4 cases of Marfan-related disorders in mixed dentition stage.2016

    • Author(s)
      Baba Y, Komazaki Y, Miyamoto JJ, Ogura K, Ahiko N, Baba Y, Tuji M, Moriyama K.
    • Organizer
      The 49th Annual Scientific Congress, Korean Association of Orthodontists
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 口唇口蓋裂患者において長期的構音障害は聴覚認知様式に影響を与える.2015

    • Author(s)
      疋田理奈、宮本順、誉田栄一、勝山成美、倉林亨、泰羅雅登、森山啓司.
    • Organizer
      第74回日本矯正歯科学会大会
    • Place of Presentation
      福岡国際会議場 博多区 福岡
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effect of mastication on satiety using an attentional bias task.2015

    • Author(s)
      Ikeda A, Miyamoto JJ, Usui N, Taira M, Moriyama K.
    • Organizer
      The 63rd Annual Meeting of Japanese Association for Dental Research.
    • Place of Presentation
      福岡国際会議場 博多区 福岡
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Association between volumetric measurements of mandibular morphology and condylar movement in facial asymmetry subjects.2015

    • Author(s)
      Ikeda M, Miyamoto JJ, Takada J, Moriyama K.
    • Organizer
      8th International Orthodontic Congress
    • Place of Presentation
      London (UK)
    • Year and Date
      2015-09-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Three-dimensional analysis of lower lip movement during articulation in patients with mandibular prognathism by motion capture system.2015

    • Author(s)
      Matsumoto T, Higashihori N, Hikita R, Watanabe C, Miyamoto J, Kawamoto T, Suzuki S, Moriyama K.
    • Organizer
      8th International Orthodontic Congress
    • Place of Presentation
      London (UK)
    • Year and Date
      2015-09-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 外科的矯正治療に伴う呼吸器能動態に舌の位置変化が与える影響.2015

    • Author(s)
      疋田理奈、東堀紀尚、宮本順、福岡裕樹、高橋由記、渡辺千穂、伊藤洋介、松本力、川元龍夫、森山啓司.
    • Organizer
      第25回日本顎変形症学会
    • Place of Presentation
      ベルサール神田 千代田区 東京
    • Year and Date
      2015-06-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 嚥下時舌運動の経時的評価に対するMRI movieの有用性.2014

    • Author(s)
      .エクプラチャヤクン・イサリア,高田潤一,井上マリステラ小百合,宮本順,誉田栄一,倉林亨,森山啓司
    • Organizer
      第73回日本矯正歯科学会大会
    • Place of Presentation
      千葉
    • Year and Date
      2014-10-20 – 2014-10-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 骨格性下顎前突患者の発音時における口腔周囲軟組織動態の検討.2014

    • Author(s)
      松本力,川元龍夫,東堀紀尚,疋田理奈,宮本順,鈴木聖一,森山啓司
    • Organizer
      第73回東京矯正歯科学会大会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Association between three-dimensional mandibular morphology and condylar movement in facial asymmetry subjects.2014

    • Author(s)
      Ikeda M, Takada J, Miyamoto JJ, Moriyama K
    • Organizer
      90th Congress of the European Orthodontic Society
    • Place of Presentation
      Warsaw, Poland
    • Year and Date
      2014-06-18 – 2014-06-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 外科的矯正治療に伴う舌骨の位置変化が睡眠時呼吸動態に及ぼす影響.2014

    • Author(s)
      疋田理奈,東堀紀尚,福岡裕樹,宮本順,川元龍夫,森山啓司
    • Organizer
      第24回日本顎変形症学会
    • Place of Presentation
      福岡
    • Year and Date
      2014-06-10 – 2014-06-11
    • Related Report
      2014 Annual Research Report

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Published: 2014-04-04   Modified: 2020-03-30  

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