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Establishment of pressure ulcer prediction method based on its pathophysiology in super-aged population

Research Project

Project/Area Number 26713058
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Gerontological nursing
Research InstitutionThe University of Tokyo

Principal Investigator

Nakagami Gojiro  東京大学, 医学(系)研究科(研究院), 講師 (70547827)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2016: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2015: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywords褥瘡 / バイオマーカー / スキンブロッティング / 非侵襲 / 皮膚 / リスクアセスメント / 看護学 / 早期発見 / 高齢者 / 動物実験 / 免疫組織化学 / メカニズム
Outline of Final Research Achievements

Predicting pressure ulcer development is important to prevent pressure ulcers. This study focused on a new assessment method based on pressure ulcer pathophysiology which includes hypoxia, ischemia-reperfusion injury, lymphatic disorder, and cell deformation. The purpose of this study was to establish a new pressure ulcer prediction method by detecting local responses against the pressure using molecular biological methods. We discovered several biomarkers that can be detected using skin blotting by the aid of our newly developed mouse model.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • Research Products

    (7 results)

All 2017 2016 Other

All Presentation (2 results) Remarks (3 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Presentation] 褥瘡発生予測のための分子マーカーに基づいた局所組織反応の検出による直接的皮膚アセスメント方法の開発2016

    • Author(s)
      木村奈緒, 仲上豪二朗, 峰松健夫, 真田弘美
    • Organizer
      第46回日本創傷治癒学会
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2016-12-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] 褥瘡発生メカニズムに着目した褥瘡発生過程マウスモデルの開発2016

    • Author(s)
      木村奈緒, 仲上豪二朗, 峰松健夫, 真田弘美
    • Organizer
      第46回日本創傷治癒学会
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2016-12-09
    • Related Report
      2016 Annual Research Report
  • [Remarks] 東京大学大学院医学系研究科老年看護学/創傷看護学分野

    • URL

      http://www.rounenkango.m.u-tokyo.ac.jp/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 東京大学大学院医学系研究科 老年看護学/創傷看護学分野

    • URL

      http://www.rounenkango.m.u-tokyo.ac.jp

    • Related Report
      2015 Annual Research Report
  • [Remarks] 東京大学大学院医学系研究科 健康科学・看護学専攻 老年看護学/創傷看護学分野

    • URL

      http://www.rounenkango.m.u-tokyo.ac.jp/

    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 褥瘡発生予測マーカー及びその使用2017

    • Inventor(s)
      真田弘美、仲上豪二朗、峰松健夫
    • Industrial Property Rights Holder
      真田弘美、仲上豪二朗、峰松健夫
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017-01-14
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] A MARKER FOR PREDICTING PRESSURE ULCER DEVELOPMENT AND A USE THEREOF2016

    • Inventor(s)
      真田弘美、仲上豪二朗、峰松健夫
    • Industrial Property Rights Holder
      真田弘美、仲上豪二朗、峰松健夫
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-01-14
    • Related Report
      2015 Annual Research Report
    • Overseas

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Published: 2014-04-04   Modified: 2018-03-22  

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