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The development of statistical models based on function data for the high-dimensional medical data

Research Project

Project/Area Number 26730023
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Statistical science
Research InstitutionShizuoka University (2015-2017)
Kurume University (2014)

Principal Investigator

Araki Yuko  静岡大学, 情報学部, 准教授 (80403913)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords関数データ解析 / 高次元データ / 判別モデル / 情報量規準 / 非線形モデル / 多変量データ解析 / スパース推定 / 構造方程式モデル / モデル選択規準 / 超高次元データ / 正則化法 / 直接効果・間接効果 / 医用データ / 正則化 / 情報量 / 基底展開 / 時空間データ / 基底展開法 / 多変量解析
Outline of Final Research Achievements

In this research, we have developed statistical models to extract useful information from super-high dimensional data without loss of information by creating some new dimension reduction techniques. We constructed a classification model which detects onset of some disease on early stage based on MRI data. Further, we elucidated a mechanism between brain structure, levels of activity and clinical endpoints. In addition, the survival model with sparse constraints were applied to the long term and large sample size follow up data aimed at realizing health longevity society in Japan. All the results described above were presented at both domestic and international conferences. We had further worked out for constructing functional structural equation modeling(SEM). However, since there were some issues which need further consideration regarding to characteristics of estimator, the SEM modeling was still developing.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (38 results)

All 2018 2017 2016 2015 2014 Other

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 10 results,  Open Access: 8 results,  Acknowledgement Compliant: 6 results) Presentation (25 results) (of which Int'l Joint Research: 4 results,  Invited: 5 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Chronic Kidney Disease and Silent Brain Infarction Increase the Risk of Vascular Cognitive Impairment in Community-dwelling Elderly Subjects: the Sefuri Study2017

    • Author(s)
      Yao H, Araki Y, Takashima Y, Uchino A, Yuzuriha T, Hashimoto M
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 26 Issue: 2 Pages: 420-424

    • DOI

      10.1016/j.jstrokecerebrovasdis.2016.10.002

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Therapeutic hypothermia for neonatal encephalopathy: a report from the first 3 years of the Baby Cooling Registry of Japan2017

    • Author(s)
      Kennosuke Tsuda, Takeo Mukai, Sachiko Iwata, Jun Shibasaki, Takuya Tokuhisa, Tomoaki Ioroi, Hiroyuki Sano, Nanae Yutaka, Akihito Takahashi, Akihito Takeuchi, Toshiki Takenouchi, Yuko Araki, Hisanori Sobajima, Masanori Tamura, Shigeharu Hosono, Makoto Nabetani, Osuke Iwata
    • Journal Title

      Scientific Reports

      Volume: 7, 39508 Issue: 1

    • DOI

      10.1038/srep39508

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hippocampal atrophy and memory dysfunction associated with physical inactivity in community-dwelling elderly subjects: The Sefuri study.2016

    • Author(s)
      Hashimoto M, Araki Y, Takashima Y, Nogami K, Uchino A, Yuzuriha T, Yao H
    • Journal Title

      Brain Behav

      Volume: 7 Issue: 2

    • DOI

      10.1002/brb3.620

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Paradoxical diurnal cortisol changes in neonates suggesting preservation of foetal adrenal rhythms.2016

    • Author(s)
      Kinoshita M, Iwata S, Okamura H, Saikusa M, Hara N, Urata C, Araki Y, Iwata O.
    • Journal Title

      Sci Rep.

      Volume: Oct 18;6:35553. Issue: 1

    • DOI

      10.1038/srep35553

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Region-specific growth restriction of brain following preterm birth.2016

    • Author(s)
      Iwata S, Katayama R, Kinoshita M, Saikusa M, Araki Y, Takashima S, Abe T, Iwata O.
    • Journal Title

      Sci Rep.

      Volume: Sep 23;6:33995. Issue: 1

    • DOI

      10.1038/srep33995

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Physiological and pathological clinical conditions and light scattering in brain.2016

    • Author(s)
      Kurata T, Iwata S, Tsuda K, Kinoshita M, Saikusa M, Hara N, Oda M, Ohmae E, Araki Y, Sugioka T, Takashima S, Iwata O.
    • Journal Title

      Sci Rep.

      Volume: Aug 11;6:31354. Issue: 1

    • DOI

      10.1038/srep31354

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Use of Normothermic Default Humidifier Settings Causes Excessive Humidification of Respiratory Gases during Therapeutic Hypothermia2016

    • Author(s)
      Tanaka Shoichiro, Iwata Sachiko, Kinoshita Masahiro, Tsuda Kennosuke, Sakai Sayaka, Saikusa Mamoru, Shindo Ryota, Harada Eimei, Okada Junichiro, Hisano Tadashi, Kanda Hiroshi, Maeno Yasuki, Araki Yuko, Ushijima Kazuo, Sakamoto Teruo, Yamashita Yushiro, and Iwata Osuke
    • Journal Title

      Therapeutic Hypothermia and Temperature Management

      Volume: 未定 Issue: 4 Pages: 180-188

    • DOI

      10.1089/ther.2016.0005

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Leisure-time physical inactivity is related to apathetic behavior in community-dwelling elderly subjects: The Sefuri study.2015

    • Author(s)
      Yao H, Takashima Y, Araki Y, Uchino A, Yuzuriha T, Hashimoto M.
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 24 Issue: 11 Pages: 2625-2631

    • DOI

      10.1016/j.jstrokecerebrovasdis.2015.07.018

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Radiation effects on DNA content of cervical cancer cells: A rapid evaluation of radiation sensitivity by laser scanning cytometry2015

    • Author(s)
      Fujiyoshi N, Ushijima K, Kawano K, Fujiyoshi k, Yamaguchi T, Araki Y, Kakuma T, Watanabe S, Kaku T, Nishida T, Kamura T
    • Journal Title

      Molecular and Clinical Oncology

      Volume: 3 Issue: 1 Pages: 51-54

    • DOI

      10.3892/mco.2014.413

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 魚鱗癬におけるリペアクト(R)の臨床効果の検討. - Clinical study for evaluation of efficacy of Repairact to ichthyosis2015

    • Author(s)
      大畑千佳, 濱田尚宏, 小野文武, 荒木由布子, 角間辰之, 橋本隆
    • Journal Title

      薬理と治療

      Volume: 43(2) Pages: 175-180

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 特別セッション「数理統計研究者と生物統計家の連携について考えよう」2017

    • Author(s)
      二宮嘉行,藤澤洋徳,高橋邦彦,田栗正隆,荒木由布子,嘉田晃子,星野崇宏
    • Organizer
      統計科学が切り拓く個別化医療:方法論・実践のフロンティア
    • Place of Presentation
      アクロス福岡(福岡県、福岡市)
    • Year and Date
      2017-03-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 潜在性脳梗塞に対する保護因子としての出産数: 地域在住の一般住民における検討2017

    • Author(s)
      八尾博史, 荒木由布子, 高島由紀, 内野晃, 杠岳文, 橋本学
    • Organizer
      第42回日本脳卒中学会総会
    • Place of Presentation
      大阪国際会議場(大阪府、大阪市)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Research-status Report
  • [Presentation] Functional path analysis with composite basis expansons2017

    • Author(s)
      Araki, Y
    • Organizer
      10th International coference on Computational and Methodological Statistics 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Risk factors for the onset of long-term care need in community-dwelling older people in Japan: 10year follow-up study of participants in the JAGES project2017

    • Author(s)
      Araki, Y
    • Organizer
      World Congress of Epidemiology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] MRI データに基づくアルツハイマー病早期発見のための統計的モデリング2017

    • Author(s)
      荒木由布子
    • Organizer
      生物統計・疫学公開講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Simulation of Optimum selection of pharmacies during a disaster in Hamamatsu City2017

    • Author(s)
      Takahashi T, Kamada T, Araki Y, Ozeki K, Okada E and Ojima T
    • Organizer
      第22回静岡健康・長寿学術フォーラム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Bayesian estimation of Birth rate2017

    • Author(s)
      Nakamura Y, Yasuhira S, and Araki Y
    • Organizer
      第22回静岡健康・長寿学術フォーラム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Comparison of the effects on analysis results by imputation of missing values in the cross-sectional study of community-dwelling elderly people in Sefuri village2017

    • Author(s)
      Ohashi J, Nasu A, Tanabe Y, Yao H and Araki Y
    • Organizer
      第22回静岡健康・長寿学術フォーラム
    • Related Report
      2017 Annual Research Report
  • [Presentation] MRIデータに基づくアルツハイマー病早期発見のための統計的モデリング2017

    • Author(s)
      荒木由布子
    • Organizer
      BIO tech 2017 アカデミックフォーラム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 地域在住一般住民における認知機能評価のための多角的アプローチ2017

    • Author(s)
      八尾博史, 荒木由布子, 高橋由紀, 内野晃
    • Organizer
      日本脳ドック学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Analysis of risk factors of silent brain infarction using the Bayesian Network: the Sefuri study.2016

    • Author(s)
      Mena, M., Terada, A. , Yao, H., Araki, Y.
    • Organizer
      第21回静岡健康・長寿学術フォーラム
    • Place of Presentation
      グランシップ(静岡県静岡市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Research-status Report
  • [Presentation] Regional comparison of risk factors related to the onset of certification of long-term care need in community-dwelling elderly people in Japan: Follow-up study of participants in the JAGES project.2016

    • Author(s)
      Kamada, T., Okuno, S., Araki, Y., Okada, E., Ojima, T.
    • Organizer
      第21回静岡健康・長寿学術フォーラム
    • Place of Presentation
      グランシップ(静岡県静岡市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Research-status Report
  • [Presentation] Propensity score analysis of causal effects of silent brain infarction on cognitive dysfunction: the Sefuri study2016

    • Author(s)
      Shimizu, T., Ishikawa, Y., Yao, H., Araki, Y.
    • Organizer
      第21回静岡健康・長寿学術フォーラム
    • Place of Presentation
      グランシップ(静岡県静岡市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Research-status Report
  • [Presentation] 大規模追跡調査に基づく要介護認定リスクモデルの提案2016

    • Author(s)
      荒木 由布子, 岡田 栄作, 尾島 俊之, 近藤 克則
    • Organizer
      複雑な生命現象を読み解くための大規模データ解析とモデリング
    • Place of Presentation
      久留米シティプラザ(福岡県福岡市)
    • Year and Date
      2016-11-07
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 潜在性脳梗塞における生物学的性差:地域在住の一般住民における検討2016

    • Author(s)
      八尾博史, 目名まりあ, 荒木由布子
    • Organizer
      第39回日本高血圧学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-09-30
    • Related Report
      2016 Research-status Report
  • [Presentation] Sparse functional classification method with composite basis function for early detection of Alzheimer's disease based on brain MRI.2016

    • Author(s)
      Araki, Y., Kawaguchi, A.
    • Organizer
      The XXVIIIth International Biometric Conference.
    • Place of Presentation
      Victoria Conference Centre(バンクーバー、カナダ)
    • Year and Date
      2016-07-10
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Physical inactivity associated with vascular depression or apathy leads to hippocampal atrophy and memory dysfunction in community-dwelling elderly subjects: The Sefuri study2016

    • Author(s)
      Yao H, Araki Y,Takashima Y, Nogami K, Uchino A, Yuzuriha T, Hashimoto M.
    • Organizer
      International Stroke Conference
    • Place of Presentation
      Los Angeles, USA
    • Year and Date
      2016-02-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 10年間追跡調査に基づく要介護認定リスクモデルの探索的検討2016

    • Author(s)
      荒木 由布子, 岡田 栄作, 尾島 俊之, 近藤 克則
    • Organizer
      JAGES研究会
    • Place of Presentation
      東京大学(東京都港区)
    • Related Report
      2016 Research-status Report
  • [Presentation] 根拠に基づく医学への数理統計学の挑戦~QOLの向上のために~2016

    • Author(s)
      荒木由布子
    • Organizer
      静岡大学情報学部公開講座2016
    • Place of Presentation
      静岡大学浜松キャンパス(静岡県浜松市)
    • Related Report
      2016 Research-status Report
  • [Presentation] Intrinsic feature extraction via functional data analysis2015

    • Author(s)
      Araki Y
    • Organizer
      8th International Conference of the ERCIM WG on Computational and Methodological Statistics
    • Place of Presentation
      University of London, UK
    • Year and Date
      2015-12-12
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Elucidation of factors related to the onset of certification of long-term care need in community-dwelling elderly people in Japan:10-year follow-up study of participants in the JAGES project.2015

    • Author(s)
      Eisaku Okada,Yuko Araki,Katsunori Kondo,Hiroshi Hirai,Toshiyuki Ojima
    • Organizer
      第20回静岡健康・長寿学術フォーラム
    • Place of Presentation
      グランシップ
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 10年間追跡調査に基づく高齢者の 要介護認定リスク因子の探索的検討2015

    • Author(s)
      荒木由布子, 岡田栄作, 近藤克則, 尾島 俊之
    • Organizer
      科研費シンポジウム「生命科学データ解析の方 法論と健康科学への応用」
    • Place of Presentation
      東京大学医科学研究所
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report
  • [Presentation] Statistics modeling for high dimensional data and its application in Biostatistics ~Functional sparse logistic discrimination via composite basis expansions~2015

    • Author(s)
      荒木 由布子
    • Organizer
      第8回東海地区生物統計ネットワークセミナー
    • Place of Presentation
      名古屋大学
    • Year and Date
      2015-05-27
    • Related Report
      2015 Research-status Report
  • [Presentation] 大腸病変によるNBI観察下surface pattern・vascular patternと病理組織構築の関係2014

    • Author(s)
      前山泰彦, 野田哲裕, 長田修一郎, 河野弘志, 秋葉純, 荒木由布子, 角間辰之, 光山慶一, 鶴田修, 鳥村拓司
    • Organizer
      第88回日本消化器内視鏡学会総会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2014-10-23 – 2014-10-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Two-step regularized Cox proportional hazard model for high-dimensional brain MRI data2014

    • Author(s)
      Araki, Y., Kawaguchi, A.
    • Organizer
      27th International Biometric Conference
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2014-07-06 – 2014-07-11
    • Related Report
      2014 Research-status Report
  • [Book] バイオ統計の基礎 : 医薬統計入門 (第5刷)2018

    • Author(s)
      柳川 尭、荒木 由布子
    • Total Pages
      258
    • Publisher
      近代科学社
    • ISBN
      9784764903876
    • Related Report
      2017 Annual Research Report
  • [Book] バイオ統計シリーズ1 バイオ統計の基礎-医薬統計入門- Kindle版2016

    • Author(s)
      柳川堯, 荒木由布子
    • Total Pages
      258
    • Publisher
      近代科学社
    • Related Report
      2016 Research-status Report
  • [Remarks] 静岡大学教員データベース

    • URL

      https://tdb.shizuoka.ac.jp/RDB/public/Default2.aspx?id=11166&l=0

    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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