The development of statistical models based on function data for the high-dimensional medical data

• Project/Area Number: 26730023
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Statistical science
• Research Institution: Shizuoka University (2015-2017); Kurume University (2014)
• Principal Investigator: Araki Yuko 静岡大学, 情報学部, 准教授 (80403913)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 関数データ解析 / 高次元データ / 判別モデル / 情報量規準 / 非線形モデル / 多変量データ解析 / スパース推定 / 構造方程式モデル / モデル選択規準 / 超高次元データ / 正則化法 / 直接効果・間接効果 / 医用データ / 正則化 / 情報量 / 基底展開 / 時空間データ / 基底展開法 / 多変量解析

Outline of Final Research Achievements

In this research, we have developed statistical models to extract useful information from super-high dimensional data without loss of information by creating some new dimension reduction techniques. We constructed a classification model which detects onset of some disease on early stage based on MRI data. Further, we elucidated a mechanism between brain structure, levels of activity and clinical endpoints. In addition, the survival model with sparse constraints were applied to the long term and large sample size follow up data aimed at realizing health longevity society in Japan. All the results described above were presented at both domestic and international conferences. We had further worked out for constructing functional structural equation modeling(SEM). However, since there were some issues which need further consideration regarding to characteristics of estimator, the SEM modeling was still developing.

Research Products

• [Journal Article] Chronic Kidney Disease and Silent Brain Infarction Increase the Risk of Vascular Cognitive Impairment in Community-dwelling Elderly Subjects: the Sefuri Study (2017)
  • Author(s): Yao H, Araki Y, Takashima Y, Uchino A, Yuzuriha T, Hashimoto M
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 26 Issue: 2 Pages: 420-424
  • DOI: 10.1016/j.jstrokecerebrovasdis.2016.10.002
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Therapeutic hypothermia for neonatal encephalopathy: a report from the first 3 years of the Baby Cooling Registry of Japan (2017)
  • Author(s): Kennosuke Tsuda, Takeo Mukai, Sachiko Iwata, Jun Shibasaki, Takuya Tokuhisa, Tomoaki Ioroi, Hiroyuki Sano, Nanae Yutaka, Akihito Takahashi, Akihito Takeuchi, Toshiki Takenouchi, Yuko Araki, Hisanori Sobajima, Masanori Tamura, Shigeharu Hosono, Makoto Nabetani, Osuke Iwata
  • Journal Title: Scientific Reports Volume: 7, 39508 Issue: 1
  • DOI: 10.1038/srep39508
  • Peer Reviewed / Open Access
• [Journal Article] Hippocampal atrophy and memory dysfunction associated with physical inactivity in community-dwelling elderly subjects: The Sefuri study. (2016)
  • Author(s): Hashimoto M, Araki Y, Takashima Y, Nogami K, Uchino A, Yuzuriha T, Yao H
  • Journal Title: Brain Behav Volume: 7 Issue: 2
  • DOI: 10.1002/brb3.620
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Paradoxical diurnal cortisol changes in neonates suggesting preservation of foetal adrenal rhythms. (2016)
  • Author(s): Kinoshita M, Iwata S, Okamura H, Saikusa M, Hara N, Urata C, Araki Y, Iwata O.
  • Journal Title: Sci Rep. Volume: Oct 18;6:35553. Issue: 1
  • DOI: 10.1038/srep35553
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Region-specific growth restriction of brain following preterm birth. (2016)
  • Author(s): Iwata S, Katayama R, Kinoshita M, Saikusa M, Araki Y, Takashima S, Abe T, Iwata O.
  • Journal Title: Sci Rep. Volume: Sep 23;6:33995. Issue: 1
  • DOI: 10.1038/srep33995
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Physiological and pathological clinical conditions and light scattering in brain. (2016)
  • Author(s): Kurata T, Iwata S, Tsuda K, Kinoshita M, Saikusa M, Hara N, Oda M, Ohmae E, Araki Y, Sugioka T, Takashima S, Iwata O.
  • Journal Title: Sci Rep. Volume: Aug 11;6:31354. Issue: 1
  • DOI: 10.1038/srep31354
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Use of Normothermic Default Humidifier Settings Causes Excessive Humidification of Respiratory Gases during Therapeutic Hypothermia (2016)
  • Author(s): Tanaka Shoichiro, Iwata Sachiko, Kinoshita Masahiro, Tsuda Kennosuke, Sakai Sayaka, Saikusa Mamoru, Shindo Ryota, Harada Eimei, Okada Junichiro, Hisano Tadashi, Kanda Hiroshi, Maeno Yasuki, Araki Yuko, Ushijima Kazuo, Sakamoto Teruo, Yamashita Yushiro, and Iwata Osuke
  • Journal Title: Therapeutic Hypothermia and Temperature Management Volume: 未定 Issue: 4 Pages: 180-188
  • DOI: 10.1089/ther.2016.0005
  • Peer Reviewed
• [Journal Article] Leisure-time physical inactivity is related to apathetic behavior in community-dwelling elderly subjects: The Sefuri study. (2015)
  • Author(s): Yao H, Takashima Y, Araki Y, Uchino A, Yuzuriha T, Hashimoto M.
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 24 Issue: 11 Pages: 2625-2631
  • DOI: 10.1016/j.jstrokecerebrovasdis.2015.07.018
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Radiation effects on DNA content of cervical cancer cells: A rapid evaluation of radiation sensitivity by laser scanning cytometry (2015)
  • Author(s): Fujiyoshi N, Ushijima K, Kawano K, Fujiyoshi k, Yamaguchi T, Araki Y, Kakuma T, Watanabe S, Kaku T, Nishida T, Kamura T
  • Journal Title: Molecular and Clinical Oncology Volume: 3 Issue: 1 Pages: 51-54
  • DOI: 10.3892/mco.2014.413
  • Peer Reviewed / Open Access
• [Journal Article] 魚鱗癬におけるリペアクト（R)の臨床効果の検討. - Clinical study for evaluation of efficacy of Repairact to ichthyosis (2015)
  • Author(s): 大畑千佳, 濱田尚宏, 小野文武, 荒木由布子, 角間辰之, 橋本隆
  • Journal Title: 薬理と治療 Volume: 43(2) Pages: 175-180
  • Peer Reviewed
• [Presentation] 特別セッション「数理統計研究者と生物統計家の連携について考えよう」 (2017)
  • Author(s): 二宮嘉行,藤澤洋徳,高橋邦彦,田栗正隆,荒木由布子,嘉田晃子,星野崇宏
  • Organizer: 統計科学が切り拓く個別化医療：方法論・実践のフロンティア
  • Place of Presentation: アクロス福岡(福岡県、福岡市）
  • Year and Date: 2017-03-27
• [Presentation] 潜在性脳梗塞に対する保護因子としての出産数： 地域在住の一般住民における検討 (2017)
  • Author(s): 八尾博史, 荒木由布子, 高島由紀, 内野晃, 杠岳文, 橋本学
  • Organizer: 第42回日本脳卒中学会総会
  • Place of Presentation: 大阪国際会議場（大阪府、大阪市）
  • Year and Date: 2017-03-16
• [Presentation] Functional path analysis with composite basis expansons (2017)
  • Author(s): Araki, Y
  • Organizer: 10th International coference on Computational and Methodological Statistics 2017
  • Int'l Joint Research / Invited
• [Presentation] Risk factors for the onset of long-term care need in community-dwelling older people in Japan: 10year follow-up study of participants in the JAGES project (2017)
  • Author(s): Araki, Y
  • Organizer: World Congress of Epidemiology 2017
  • Int'l Joint Research
• [Presentation] MRI データに基づくアルツハイマー病早期発見のための統計的モデリング (2017)
  • Author(s): 荒木由布子
  • Organizer: 生物統計・疫学公開講演会
  • Invited
• [Presentation] Simulation of Optimum selection of pharmacies during a disaster in Hamamatsu City (2017)
  • Author(s): Takahashi T, Kamada T, Araki Y, Ozeki K, Okada E and Ojima T
  • Organizer: 第22回静岡健康・長寿学術フォーラム
• [Presentation] Bayesian estimation of Birth rate (2017)
  • Author(s): Nakamura Y, Yasuhira S, and Araki Y
  • Organizer: 第22回静岡健康・長寿学術フォーラム
• [Presentation] Comparison of the effects on analysis results by imputation of missing values in the cross-sectional study of community-dwelling elderly people in Sefuri village (2017)
  • Author(s): Ohashi J, Nasu A, Tanabe Y, Yao H and Araki Y
  • Organizer: 第22回静岡健康・長寿学術フォーラム
• [Presentation] MRIデータに基づくアルツハイマー病早期発見のための統計的モデリング (2017)
  • Author(s): 荒木由布子
  • Organizer: BIO tech 2017 アカデミックフォーラム
  • Invited
• [Presentation] 地域在住一般住民における認知機能評価のための多角的アプローチ (2017)
  • Author(s): 八尾博史, 荒木由布子, 高橋由紀, 内野晃
  • Organizer: 日本脳ドック学会総会
• [Presentation] Analysis of risk factors of silent brain infarction using the Bayesian Network: the Sefuri study. (2016)
  • Author(s): Mena, M., Terada, A. , Yao, H., Araki, Y.
  • Organizer: 第21回静岡健康・長寿学術フォーラム
  • Place of Presentation: グランシップ（静岡県静岡市）
  • Year and Date: 2016-11-25
• [Presentation] Regional comparison of risk factors related to the onset of certification of long-term care need in community-dwelling elderly people in Japan: Follow-up study of participants in the JAGES project. (2016)
  • Author(s): Kamada, T., Okuno, S., Araki, Y., Okada, E., Ojima, T.
  • Organizer: 第21回静岡健康・長寿学術フォーラム
  • Place of Presentation: グランシップ（静岡県静岡市）
  • Year and Date: 2016-11-25
• [Presentation] Propensity score analysis of causal effects of silent brain infarction on cognitive dysfunction: the Sefuri study (2016)
  • Author(s): Shimizu, T., Ishikawa, Y., Yao, H., Araki, Y.
  • Organizer: 第21回静岡健康・長寿学術フォーラム
  • Place of Presentation: グランシップ（静岡県静岡市）
  • Year and Date: 2016-11-25
• [Presentation] 大規模追跡調査に基づく要介護認定リスクモデルの提案 (2016)
  • Author(s): 荒木 由布子, 岡田 栄作, 尾島 俊之, 近藤 克則
  • Organizer: 複雑な生命現象を読み解くための大規模データ解析とモデリング
  • Place of Presentation: 久留米シティプラザ（福岡県福岡市）
  • Year and Date: 2016-11-07
  • Invited
• [Presentation] 潜在性脳梗塞における生物学的性差：地域在住の一般住民における検討 (2016)
  • Author(s): 八尾博史, 目名まりあ, 荒木由布子
  • Organizer: 第39回日本高血圧学会総会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-09-30
• [Presentation] Sparse functional classification method with composite basis function for early detection of Alzheimer's disease based on brain MRI. (2016)
  • Author(s): Araki, Y., Kawaguchi, A.
  • Organizer: The XXVIIIth International Biometric Conference.
  • Place of Presentation: Victoria Conference Centre（バンクーバー、カナダ）
  • Year and Date: 2016-07-10
  • Int'l Joint Research
• [Presentation] Physical inactivity associated with vascular depression or apathy leads to hippocampal atrophy and memory dysfunction in community-dwelling elderly subjects: The Sefuri study (2016)
  • Author(s): Yao H, Araki Y,Takashima Y, Nogami K, Uchino A, Yuzuriha T, Hashimoto M.
  • Organizer: International Stroke Conference
  • Place of Presentation: Los Angeles, USA
  • Year and Date: 2016-02-17
• [Presentation] 10年間追跡調査に基づく要介護認定リスクモデルの探索的検討 (2016)
  • Author(s): 荒木 由布子, 岡田 栄作, 尾島 俊之, 近藤 克則
  • Organizer: JAGES研究会
  • Place of Presentation: 東京大学（東京都港区）
• [Presentation] 根拠に基づく医学への数理統計学の挑戦～QOLの向上のために～ (2016)
  • Author(s): 荒木由布子
  • Organizer: 静岡大学情報学部公開講座2016
  • Place of Presentation: 静岡大学浜松キャンパス（静岡県浜松市）
• [Presentation] Intrinsic feature extraction via functional data analysis (2015)
  • Author(s): Araki Y
  • Organizer: 8th International Conference of the ERCIM WG on Computational and Methodological Statistics
  • Place of Presentation: University of London, UK
  • Year and Date: 2015-12-12
  • Int'l Joint Research / Invited
• [Presentation] Elucidation of factors related to the onset of certification of long-term care need in community-dwelling elderly people in Japan:10-year follow-up study of participants in the JAGES project. (2015)
  • Author(s): Eisaku Okada,Yuko Araki,Katsunori Kondo,Hiroshi Hirai,Toshiyuki Ojima
  • Organizer: 第20回静岡健康・長寿学術フォーラム
  • Place of Presentation: グランシップ
  • Year and Date: 2015-10-30
• [Presentation] 10年間追跡調査に基づく高齢者の 要介護認定リスク因子の探索的検討 (2015)
  • Author(s): 荒木由布子, 岡田栄作, 近藤克則, 尾島 俊之
  • Organizer: 科研費シンポジウム「生命科学データ解析の方 法論と健康科学への応用」
  • Place of Presentation: 東京大学医科学研究所
  • Year and Date: 2015-10-16
• [Presentation] Statistics modeling for high dimensional data and its application in Biostatistics ~Functional sparse logistic discrimination via composite basis expansions~ (2015)
  • Author(s): 荒木 由布子
  • Organizer: 第8回東海地区生物統計ネットワークセミナー
  • Place of Presentation: 名古屋大学
  • Year and Date: 2015-05-27
• [Presentation] 大腸病変によるNBI観察下surface pattern・vascular patternと病理組織構築の関係 (2014)
  • Author(s): 前山泰彦, 野田哲裕, 長田修一郎, 河野弘志, 秋葉純, 荒木由布子, 角間辰之, 光山慶一, 鶴田修, 鳥村拓司
  • Organizer: 第８８回日本消化器内視鏡学会総会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2014-10-23 – 2014-10-26
• [Presentation] Two-step regularized Cox proportional hazard model for high-dimensional brain MRI data (2014)
  • Author(s): Araki, Y., Kawaguchi, A.
  • Organizer: 27th International Biometric Conference
  • Place of Presentation: Florence, Italy
  • Year and Date: 2014-07-06 – 2014-07-11
• [Book] バイオ統計の基礎 : 医薬統計入門 （第5刷） (2018)
  • Author(s): 柳川 尭、荒木 由布子
  • Total Pages: 258
  • Publisher: 近代科学社
  • ISBN: 9784764903876
• [Book] バイオ統計シリーズ1 バイオ統計の基礎-医薬統計入門- Kindle版 (2016)
  • Author(s): 柳川堯, 荒木由布子
  • Total Pages: 258
  • Publisher: 近代科学社
• [Remarks] 静岡大学教員データベース
  • URL: https://tdb.shizuoka.ac.jp/RDB/public/Default2.aspx?id=11166&l=0