| Project/Area Number |
26740019
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Yokohama City University |
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Principal Investigator |
Kurosawa Aya 横浜市立大学, 生命ナノシステム科学研究科, 客員研究員 (70505867)
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| Research Collaborator |
ADACHI Noritaka 横浜市立大学, 生命ナノシステム科学研究科, 教授 (30264675)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | DNA repair / NHEJ / DNA-PKcs / DNA依存性プロテインキナーゼ / 非相同末端連結 |
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| Outline of Final Research Achievements |
The aim of this study was to investigate the role of the PRKDC, one of the causative genes for microcephaly, in neurogenesis. As human gene-knockout iPS cells are useful in understanding disease mechanisms, we established the protocol for generation of human gene-knockout iPS cells using a plasmid-based targeting vector.
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