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Clarification of the congener pattern of unintentional PCBs, and study on their effects on living organisms

Research Project

Project/Area Number 26740032
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Environmental impact assessment
Research InstitutionHokkaido Research Organization

Principal Investigator

ANEZAKI Katsunori  地方独立行政法人北海道立総合研究機構, 環境・地質研究本部環境科学研究センター, 研究主任 (20442634)

Research Collaborator HASHIMOTO Shunji  国立研究開発法人・国立環境研究所, 環境計測研究センター・応用計測化学研究室
NAKANO Takeshi  国立大学法人・大阪大学, 環境安全研究管理センター
KASHIWAGI Nobuhisa  大学共同利用期間法人・情報・システム研究機構, 統計数理研究所
KOJIMA Hiroyuki  
TAKEUCHI Shinji  北海道立衛生研究所
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
KeywordsPCB / 非意図的生成 / ベイズ形半因子モデル / 生物濃縮 / レポータージーンアッセイ / 生体影響 / PCBs / ベイズ型版因子モデル / レポートジーンアッセイ
Outline of Final Research Achievements

Chlorophenylsilanes are PCBs produced unintentionally during the manufacturing of pigments and chemical products. It was observed that the specific congeners of PCBs had antagonistic activities on the estrogen-receptor (ER) α and β, mediated via 10 kinds of nuclear receptors. The dynamics of unintentionally produced PCBs in the environment were discussed. It was found that the effects of Kanechlor in the atmosphere and sediments were strong, and that the PCBs included in azo pigments have some effects. However, little pigment-derived PCBs were included in the blubber and liver of marine mammals.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (14 results)

All 2017 2016 2015 2014

All Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 3 results,  Acknowledgement Compliant: 5 results) Presentation (8 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Effects of unintentional PCBs in pigments and chemical products on transcriptional activity via aryl hydrocarbon and nuclear hormone receptors2017

    • Author(s)
      Shinji Takeuchi, Katsunori Anezaki, Hiroyuki Kojima
    • Journal Title

      Environmental Pollution

      Volume: 227 Pages: 306-313

    • DOI

      10.1016/j.envpol.2017.04.059

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Concentration and congener pattern of polychlorinated biphenyls in blubber and liver of Hubbs' beaked whale (Mesoplodon carlhubbsi), using a sulfoxide and an Ag-ION solid phase extraction cartridge as a simplified cleanup technique for biological samples2016

    • Author(s)
      Anezaki K, Matsuda A, Matsuishi T
    • Journal Title

      Marine Pollution Bulletin

      Volume: 113(1-2) Issue: 1-2 Pages: 282-286

    • DOI

      10.1016/j.marpolbul.2016.09.051

    • NAID

      120006543290

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Estimation of Polychlorinated Biphenyl Sources in Industrial Port Sediments Using a Bayesian Semifactor Model Considering Unidentified Sources2016

    • Author(s)
      Katsunori Anezaki, Takeshi Nakano, Nobuhisa Kashiwagi
    • Journal Title

      Environ. Sci. Technol.

      Volume: 50 Issue: 2 Pages: 765-771

    • DOI

      10.1021/acs.est.5b03501

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] ESTIMATION OF POLYCHLORINATED BIPHENYL SOURCES IN SEDIMENT USING A BAYESIAN SEMI-FACTOR MODEL WITH CONSIDERATION OF UNIDENTIFIED SOURCES2015

    • Author(s)
      Katsunori Anezaki, Takeshi Nakano, Nobuhisa Kashiwagi
    • Journal Title

      Organohalogen Compounds

      Volume: 77 Pages: 266-269

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Unintentional PCB in chlorophenylsilanes as a source ofcontamination in environmental samples2015

    • Author(s)
      Katsunori Anezaki, Takeshi Nakano
    • Journal Title

      Journal of Hazardous Materials

      Volume: 287 Pages: 111-117

    • DOI

      10.1016/j.jhazmat.2015.01.026

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] PCB CONGENER PROFILE OF UNINTENTIONAL FORMATION FROM PIGMENT MANUFACTURING PROCESS2014

    • Author(s)
      Katsunori Anezaki, Takeshi Nakano
    • Journal Title

      Organohalogen Compounds

      Volume: 76

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 北海道様似町に漂着したハッブスオウギハクジラ(Mesoplodon carlhubbsi)の脂皮及び肝臓中のPCBsの濃度とコンジェナー組成2016

    • Author(s)
      姉崎克典、松田純佳、松石隆
    • Organizer
      日本分析化学会第65年会
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 秋期の田園地区における大気中ダイオキシン類及びPCBsの日間変動2016

    • Author(s)
      姉崎克典、永洞真一郎
    • Organizer
      日本分析化学会第65年会
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] ESTIMATION OF POLYCHLORINATED BIPHENYL SOURCES IN SEDIMENT USING A BAYESIAN SEMI-FACTOR MODEL WITH CONSIDERATION OF UNIDENTIFIED SOURCES2015

    • Author(s)
      Katsunori Anezaki, Takeshi Nakano, Nobuhisa Kashiwagi
    • Organizer
      35th International Symposium on Halogenated Persistent Organic Pollutants (DIOXIN 2015)
    • Place of Presentation
      São Paulo, Brazil
    • Year and Date
      2015-08-23
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ベイズ型組成半因子モデルを用いた環境中のPCBs汚染由来の推定2015

    • Author(s)
      姉崎克典,柏木宣久
    • Organizer
      第24回環境化学討論会
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2015-06-24
    • Related Report
      2015 Research-status Report
  • [Presentation] 色素や化成品に含まれるPCBの核内受容体及びダイオキシン受容体を介した作用2015

    • Author(s)
      武内伸治,姉崎克典,小島弘幸
    • Organizer
      第24回環境化学討論会
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2015-06-24
    • Related Report
      2015 Research-status Report
  • [Presentation] UNINTENTIONAL PCB CONTAMINATION IN CHLOROPHENYSILANE COMPOUNDS2014

    • Author(s)
      Katsunori ANEZAKI, Takeshi NAKANO
    • Organizer
      International Conference of Asian Environmental Chemistry (ICAEC2014)
    • Place of Presentation
      Lak Si Bangkok, THAILAND
    • Year and Date
      2014-11-24 – 2014-11-26
    • Related Report
      2014 Research-status Report
  • [Presentation] PCB CONGENER PROFILE OF UNINTENTIONAL FORMATION FROM PIGMENT MANUFACTURING PROCESS2014

    • Author(s)
      Katsunori Anezaki, Takeshi Nakano
    • Organizer
      34th International Symposium on Halogenated Persistent Organic Pollutants -Dioxin 2014
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2014-08-31 – 2014-09-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 化成品に含まれる非意図的生成PCBs2014

    • Author(s)
      姉崎克典,中野武
    • Organizer
      第23回環境化学討論会
    • Place of Presentation
      京都府京都市
    • Year and Date
      2014-05-14 – 2014-05-16
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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