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Lipid metabolism modulating effects of isoflavone aglycone in lactic acid-fermented soymilk

Research Project

Project/Area Number 26750028
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Eating habits
Research InstitutionHyogo University

Principal Investigator

Kobayashi Maki  兵庫大学, 健康科学部, 講師 (70550789)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordslipid metabolism / isoflavone / soy protein / 脂質代謝 / イソフラボン / 大豆タンパク質 / 遺伝子 / メタボローム解析
Outline of Final Research Achievements

Treating soy milk with lactic acid fermentation improves its lipid metabolism-modulating effects. We analyzed the effects of the active ingredients in lactic acid-fermented soy milk that contribute to this improvement. Lactic acid fermentation of soy milk strengthened its lipid metabolism-modulating effects. However, this effect was not observed with isoflavone aglycone or soy protein alone, suggesting that the combination of soy protein and isoflavone aglycone produces the effect. In addition, lactic acid fermentation causes oligo peptides to form, converts the polyphenols from their glycoside to aglycone forms, and increases ornithine content. These changes could be contributing to the improvement in lipid metabolism seen with lactic acid fermented soy milk.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Isoflavone Aglycones and Oligopeptides in Lactic Acid-Fermented Soy Milk Differentially Regulate Lipid Metabolism-Related Gene Expression.2016

    • Author(s)
      Kobayashi, M., Egusa, S. and Fukuda, M.
    • Journal Title

      Food and Nutrition Sciences

      Volume: 7 Issue: 11 Pages: 989-1009

    • DOI

      10.4236/fns.2016.711097

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Isoflavone and Protein Constituents of Lactic Acid-Fermented Soy Milk Combine to Prevent Dyslipidemia in Rats Fed a High Cholesterol Diet2014

    • Author(s)
      Maki Kobayashi, Shintaro Egusa, Mitsuru Fukuda
    • Journal Title

      Nutrients

      Volume: 6 Issue: 12 Pages: 5704-5723

    • DOI

      10.3390/nu6125704

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 乳酸発酵豆乳中のイソフラボンアグリコンとオリゴペプチドの脂質代謝関連遺伝子発現に及ぼす影響について2016

    • Author(s)
      小林麻貴、江草信太郎、福田 満
    • Organizer
      第70回日本栄養・食糧学会大会
    • Place of Presentation
      武庫川女子大学
    • Year and Date
      2016-05-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] 乳酸発酵豆乳中のイソフラボンとタンパク質は共存することで高コレステロール食投与ラットの脂質異常症を予防する2016

    • Author(s)
      小林麻貴、江草信太郎、福田満
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] Hypocholesterolemic Effects of Lactic Acid-Fermented Soymilk on Rats Fed a High Cholesterol Diet2015

    • Author(s)
      小林麻貴、江草信太郎、福田満
    • Organizer
      第12回アジア栄養学会議(12th Asian Congress of Nutrition)
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-05-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 乳酸発酵豆乳抽出物が高コレステロール食投与ラットの脂質代謝に及ぼす影響2015

    • Author(s)
      小林麻貴、江草信太郎、福田満
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Research-status Report
  • [Presentation] 乳酸発酵豆乳のイソフラボン含量が高コレステロール食投与ラットの脂質代謝に及ぼす影響2014

    • Author(s)
      小林麻貴、江草信太郎、福田 満
    • Organizer
      第68回栄養食糧学会大会
    • Place of Presentation
      酪農学園大学
    • Year and Date
      2014-05-30 – 2014-06-01
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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