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An investigation of the basic principle of feeding behavior: gustatory cortical mapping by a single neuron labeling method

Research Project

Project/Area Number 26750043
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Eating habits
Research InstitutionKagoshima University

Principal Investigator

Iwai Haruki  鹿児島大学, 医歯学域歯学系, 助教 (30452949)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords味覚 / 視床 / 神経回路 / 内臓感覚
Outline of Final Research Achievements

To reveal an overview of projections from gustatory related thalamus to the caudate putamen (CPu) and cerebral cortex, we analyzed cell groups and single neurons in these brain areas using morphological and physiological methods. As a result, the oval paracentral nucleus of the thalamus projected to the ventrocentral CPu; ventrolateral parafascicular nucleus projected to the ventrolateral CPu; caudal central medial nucleus, ventromedial parafascicular nucleus, and retroreuniens area projected to the ventromedial CPu; and parvicellular part of the posteromedial ventral nucleus (VPMpc) projected to the interstitial nucleus of the posterior limb of the anterior commissure. Furthermore, the caudal central medial nucleus and VPMpc projected to the insular cortex. These results suggest that projections from gustatory related thalamus to the ventral CPu are topographically organized. Projections from gustatory related thalamus to the insular cortex are currently under analysis.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (33 results)

All 2017 2016 2015 2014 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 4 results,  Open Access: 4 results) Presentation (23 results) (of which Int'l Joint Research: 4 results) Remarks (4 results)

  • [Journal Article] Individual Mediodorsal Thalamic Neurons Project to Multiple Areas of the Rat Prefrontal Cortex: A Single Neuron-Tracing Study Using Virus Vectors.2017

    • Author(s)
      Kuramoto E, Pan SX, Furuta T, Tanaka YR, Iwai H, Yamanaka A, Ohno S, Kaneko T, Goto T, Hioki H.
    • Journal Title

      J Comp Neurol

      Volume: 525 Issue: 1 Pages: 166-185

    • DOI

      10.1002/cne.24054

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Neuropeptides and ATP signaling in the trigeminal ganglion.2017

    • Author(s)
      Goto T, Iwai H, Kumamoto E, Yamanaka A
    • Journal Title

      Jpn Dent Sci Rev

      Volume: 印刷中 Issue: 4 Pages: 117-124

    • DOI

      10.1016/j.jdsr.2017.01.003

    • NAID

      210000165280

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The effect of repeated stress on KCC2 and NKCC1 immunoreactivity in the hippocampus of female mice2016

    • Author(s)
      Tsukahara T, Masuhara M, Iwai H, Sonomura T and Sato T.
    • Journal Title

      Data in Brief.

      Volume: 6 Pages: 521-525

    • DOI

      10.1016/j.dib.2015.12.041

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ascending parabrachio-thalamo-striatal pathways: Potential circuits for integration of gustatory and oral motor functions.2015

    • Author(s)
      Iwai H, Kuramoto E, Yamanaka A, Sonomura T, Uemura M, Goto T.
    • Journal Title

      Neuroscience

      Volume: 294 Pages: 1-13

    • DOI

      10.1016/j.neuroscience.2015.02.045

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Repeated stress-induced expression pattern alterations of the hippocampal chloride transporters KCC2 and NKCC1 associated with behavioral abnormalities in female mice2015

    • Author(s)
      Tsukahara T, Masuhara M, Iwai H, Sonomura T and Sato T.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 465 Issue: 1 Pages: 145-151

    • DOI

      10.1016/j.bbrc.2015.07.153

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Patterning of mammalian heterodont dentition within the upper and lower jaws2015

    • Author(s)
      Yamanaka Atushi, Haruki Iwai, Masanori Uemura, and Tetsuya Goto
    • Journal Title

      Evolution & Development

      Volume: 17 Issue: 2 Pages: 127-138

    • DOI

      10.1111/ede.12116

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] ラット三叉神経節における神経細胞-衛星細胞-マクロファージ様細胞間の細胞外ATPによる情報伝達機構2017

    • Author(s)
      岩井 治樹、倉本 恵梨子、山中 淳之、後藤 哲哉
    • Organizer
      第122回 日本解剖学会総会・全国学術大会
    • Place of Presentation
      長崎大学 (長崎県長崎市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Dorsal and ventral parts of the thalamic nucleus submedius provide two independent inputs to different areas of the rat orbitofrontal cortex: A single neuron-tracing study using virus vectors2016

    • Author(s)
      E. KURAMOTO1, H. IWAI, A. YAMANAKA, S. OHNO, R. SENDO, K. KOYANAGI, S. TOYODOME, T. FURUTA, H. HIOKI, T. GOTO
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ラット三叉神経節における VNUT を介した神経細胞、衛星細胞、およびミクログリア様細胞間の細胞外 ATP 情報伝達2016

    • Author(s)
      岩井治樹、倉本恵梨子、山中淳之、後藤哲哉
    • Organizer
      第58回 歯科基礎医学会学術大会
    • Place of Presentation
      札幌コンベンションセンター (北海道札幌市)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 口腔感覚に関わる末梢-中枢神経間の賦活系および抑制系ネットワーク2016

    • Author(s)
      倉本恵梨子,岩井治樹,山中淳之,後藤哲哉
    • Organizer
      第58回 歯科基礎医学会学術大会
    • Place of Presentation
      札幌コンベンションセンター (北海道札幌市)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 三叉神経系における痛覚伝達経路および中枢からの下行性制御について2016

    • Author(s)
      後藤哲哉,倉本恵梨子,岩井治樹
    • Organizer
      第58回 歯科基礎医学会学術大会
    • Place of Presentation
      札幌コンベンションセンター (北海道札幌市)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 組織透明化と神経トレース技術によるラット三叉神経節細胞の三次元的体部位局在の解析2016

    • Author(s)
      千堂良造,岩井治樹,倉本恵梨子,吉村成美,山口留奈,山中淳之,豊留宗一郎,杉村光隆
    • Organizer
      第58回 歯科基礎医学会学術大会
    • Place of Presentation
      札幌コンベンションセンター (北海道札幌市)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Substance P によるマウス骨芽細胞の骨形成に対するNK1 受容体ノックダウンの影響について2016

    • Author(s)
      豊留宗一郎,倉本恵梨子,岩井治樹,山中淳之,吉村卓也,中村典史,後藤哲哉
    • Organizer
      第58回 歯科基礎医学会学術大会
    • Place of Presentation
      札幌コンベンションセンター (北海道札幌市)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 現生トガリネズミ科の臼歯歯冠の発生と中生代哺乳類のトリボスフェニック型臼歯の進化の関係2016

    • Author(s)
      山中淳之、岩井治樹、倉本恵梨子、後藤哲哉
    • Organizer
      第58回 歯科基礎医学会学術大会
    • Place of Presentation
      札幌コンベンションセンター (北海道札幌市)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Neuron-satellite glia-microglia signaling in the rat trigeminal ganglion2016

    • Author(s)
      Haruki Iwai, Eriko Kuramoto, Atsushi Yamanaka, Tetsuya Goto
    • Organizer
      第39回 日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Two types of orbitofrontal cortical projection from the rat submedial thalamic nucleus: Possible function in descending pain modulation2016

    • Author(s)
      Eriko Kuramoto,Haruki Iwai,Atsushi Yamanaka,Ryozo Sendo,Sachi Ohno,Takahiro Furuta,Hiroyuki Hioki,Tetsuya Goto
    • Organizer
      第39回 日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] ATP mediates neuron-satellite glia-microglia signaling in the rat trigeminal ganglion2016

    • Author(s)
      Haruki Iwai, Eriko Kuramoto, Atsushi Yamanaka, Tetsuya Goto
    • Organizer
      IADR GENERAL SESSION
    • Place of Presentation
      Seoul (Korea)
    • Year and Date
      2016-06-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ラット三叉神経節における神経細胞および衛星細胞の小胞型ヌクレオチドトランスポーターの発現と分布2016

    • Author(s)
      岩井治樹, 倉本恵梨子, 後藤哲哉
    • Organizer
      第121回 日本解剖学会総会・全国学術大会
    • Place of Presentation
      熊本大学 (熊本県熊本市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 味覚神経回路と摂食行動の神経回路は、視床髄板内核群尾腹側部を介して結合する2015

    • Author(s)
      岩井治樹, 倉本恵梨子, 山中淳之, 後藤哲哉
    • Organizer
      第71回解剖学会九州支部学術集会
    • Place of Presentation
      熊本大学 (熊本県熊本市)
    • Year and Date
      2015-10-31
    • Related Report
      2015 Research-status Report
  • [Presentation] Projection pattern of the ventrocaudal part of the intralaminar thalamic nucleus to the caudate putamen in the rat brain2015

    • Author(s)
      Iwai H, Kuramoto E, Yamanaka A, Goto T
    • Organizer
      Neuroscience 2015
    • Place of Presentation
      Chicago, Illinois (USA)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] A morphological analysis of thalamocortical projections arising from the rat mediodorsal nucleus: A single neuron-tracing study using viral vectors2015

    • Author(s)
      Kuramoto E, Pan S, Furuta T, Hioki H, Iwai H, Yamanaka A, Ohno S, Goto T, Kaneko T
    • Organizer
      Neuroscience 2015
    • Place of Presentation
      Chicago, Illinois (USA)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 摂食行動と内臓感覚とを結びつける新たな神経回路2015

    • Author(s)
      岩井治樹, 倉本恵梨子, 山中淳之, 後藤哲哉
    • Organizer
      第57回 歯科基礎医学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Presentation] The roles of the thalamocortical projection in descending pain modulation2015

    • Author(s)
      Kuramoto E, Iwai H, Yamanaka A, Goto T
    • Organizer
      第57回 歯科基礎医学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Presentation] Ascending parabrahio-thalamo-striatal pathways in the rat brain2015

    • Author(s)
      Iwai H, Kuramoto E, Yamanaka A, Goto T
    • Organizer
      第38回 日本神経科学大会
    • Place of Presentation
      神戸国際会議場 (兵庫県神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Gustatory pathways from the parabrachial nuclei to the ventral part of the caudate putamen via the caudal part of the intralaminar thalamic nuclei in rat brain2015

    • Author(s)
      Iwai H, Kuramoto E, Yamanaka A, Goto T
    • Organizer
      第120回 日本解剖学会総会・全国学術大会
    • Place of Presentation
      神戸国際会議場 (神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] マウス大脳新皮質の運動野における興奮性ニューロンからパルブアルブミン陽性インターニューロンへの入力の定量解析2014

    • Author(s)
      倉本恵梨子, 日置寛之, 田中康裕, 山中淳之, 岩井治樹, 大野幸, 金子武嗣, 後藤哲哉
    • Organizer
      日本解剖学会第70回九州支部学術集会
    • Place of Presentation
      産業医科大学 (北九州市)
    • Year and Date
      2014-10-25
    • Related Report
      2014 Research-status Report
  • [Presentation] ラットにおける視床髄板内核群から線条体腹側部への味覚投射2014

    • Author(s)
      岩井治樹, 山中淳之, 後藤哲哉
    • Organizer
      第56回 歯科基礎医学会学術大会
    • Place of Presentation
      福岡国際会議場 (福岡市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 強制経口投与ストレスがうつ病モデル卵巣摘出マウスの行動に及ぼす影響とGABA 神経伝達機構との関連2014

    • Author(s)
      塚原飛央, 増原正明, 薗村貴弘, 岩井治樹, 佐藤友昭
    • Organizer
      第56回 歯科基礎医学会学術大会
    • Place of Presentation
      福岡国際会議場 (福岡市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] A Morphological Analysis of Neurons in Rat Spinal Trigeminal Subnucleus Caudalis with Viral Vectors2014

    • Author(s)
      Ohno, S. Kuramoto, E., Kaneko, T., Sonomura, T., Iwai, H., Kohjitani, A., Sugiyama, K.
    • Organizer
      第37回 日本神経科学大会
    • Place of Presentation
      パシフィコ横浜 (横浜市)
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Remarks] Researchmap

    • URL

      http://researchmap.jp/iwaiharuki

    • Related Report
      2015 Research-status Report
  • [Remarks] Researchgate

    • URL

      https://www.researchgate.net/profile/Haruki_Iwai2

    • Related Report
      2015 Research-status Report
  • [Remarks] 鹿児島大学 研究者総覧

    • URL

      http://ris.kuas.kagoshima-u.ac.jp/html/100004990_ja.html

    • Related Report
      2015 Research-status Report
  • [Remarks] 鹿児島大学 歯学部 歯科機能形態学分野

    • URL

      http://w3.hal.kagoshima-u.ac.jp/dental/anatomy1/index.html

    • Related Report
      2015 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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