| Project/Area Number |
26750044
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
INAFUKU Masashi 琉球大学, 熱帯生物圏研究センター, 協力研究員 (90457458)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | グリセロリン脂質 / 食事 / 免疫 / 食事性リン脂質 / ホスファチジルイノシトール / T細胞 / コンカナバリンA / リン脂質 |
|---|
| Outline of Final Research Achievements |
Dietary glycerophospholipids affected on the increase in serum inflammatory cytokine levels of mice treated with immunostimulants.Dietary phosphatidylcholine or phosphatidylinositol inhibted these increases, whereas phosphatidylserine enhanced. Among the inflammatory cytokines, interferon-gamma levels were significantly affected by dietay phospholipids.Dietary phosphatidylinositol significantly increased the number of splenic T lymphocytes, but decreased that interferon-gamma producing T-cells. In splenic T lymphocytes of mice fed phosphoatidylinositol, significant alleviation of interferon-gamma producing ability were shown when extracellular but not intracellular activation.
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