Search of foods inhibiting lipoxygenase for prevention of allergic disease

• Project/Area Number: 26750049
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Okayama Prefectural University
• Principal Investigator: Kawakami Yuki 岡山県立大学, 保健福祉学部, 准教授 (30453202)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: リポキシゲナーゼ / 食品 / 抗アレルギー作用

Outline of Final Research Achievements

5-Lipoxygenase is an enzyme that catalyzes formation of leukotrienes. Leukotrienes are implicated in inflammatory processes and allergic reaction such as asthma. We evaluated the inhibitory effect of various foods on 5-lipoxygenase activity. We found that nutmeg contained a potent inhibitor of 5-lipoxygenase. We identified an inhibitor of 5-lipoxygenase in nutmeg and established an efficient extraction protocol.

Research Products

• [Presentation] ナツメグに含まれる5-リポキシゲナーゼ阻害成分の探索 (2016)
  • Author(s): 川上祐生、森香子、岡本憲典、大河内脩史、金山友紀、金子由季、神崎圭太、山本登志子、木本眞順美、山下広美、伊東秀之、高橋吉孝
  • Organizer: 日本農芸化学会2016年度大会
  • Place of Presentation: 札幌
  • Year and Date: 2016-03-28
• [Presentation] Myristica fragrans成分による5-リポキシゲナーゼ阻害効果 (2015)
  • Author(s): 川上祐生、森香子、岡本憲典、大河内脩史、金山友紀、金子由季、神崎圭太、 山本登志子、木本眞順美、山下広美、伊東秀之、高橋吉孝
  • Organizer: BMB2015
  • Place of Presentation: 神戸
  • Year and Date: 2015-12-01