Intrauterine hyperglycemia-induced inflammatory signalling via the receptor for advanced glycation end products in the cardiac muscle of the infants of diabetic mother rats.
| Project/Area Number |
26750054
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Takasaki University of Health and Welfare |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 妊娠 / エイコサペンタエン酸 / 糖尿病 / 子宮内高血糖 / 心臓 / EPA |
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| Outline of Final Research Achievements |
Gestational diabetes is associated with increased risk to the health of the mother and her offspring. We have previously reported that IDMs showed abnormalities in cardiac Akt-related insulin signalling, and that these deficiencies in Akt-related signalling were attenuated by supplementing the maternal diet with fish-oil.Pregnant diabetic rats were administered streptozotocin before receiving EPA. Insulin resistance as determined by diminished GLUT4 translocation following insulin stimulation, the levels of AGEs and ROS were elevated in the neonatal hearts of IDM/W compared with that seen in the offspring born from non-diabetic control animals. Similarly, the RAGEs mRNA levels, ROS and the amount of NF-κB mRNA were higher in the hearts from the IDM/W when compared to that observed in the hearts of offspring born to non-diabetic animals. These deleterious effects of gestational diabetes were significantly decreased in the offspring of diabetic mothers receiving EPA supplementation.
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Report
(5 results)
Research Products
(24 results)
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[Journal Article] Oral administration of Dictyostelium differentiation-inducing factor 1 lowers blood glucose levels in streptozotocin- induced diabetic rats.2016
Author(s)
Kawaharada, R., Nakamura, A., Takahashi, K., Kikuchi, H., Oshima, Y., and Kubohara, Y.
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Journal Title
Life Sci.
Volume: 155
Pages: 56-62
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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