| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Outline of Final Research Achievements |
Pancreatic cancer is related to diabetes. However, their causal relationship remains unclear. Toxic advanced glycation end products (toxic AGEs, named TAGE), involved in diabetic vascular complications (e.g., lifestyle-related diseases), are related to cancer. Based on this finding, we hypothesized that TAGE promote the development and progression of pancreatic cancer.
In an experiment with a fructose/glucose metabolic intermediate, glyceraldehyde (GA), i.e., the causative agent of TAGE, added to the culture medium for PANC-1 cells derived from pancreatic cancer (pancreatic duct cancer model), the production and accumulation of intracellular TAGE increased along with an increased concentration of GA incorporated into the cells. In addition, abnormalities were found in proteins involved in cancer invasion and cell death.
|
