Mechanistic study of anticancer activities of isoflavone components in breast cancer
| Project/Area Number |
26750059
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Nakamura Gakuen College |
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Principal Investigator |
Misaki Ono 中村学園大学, 栄養科学部, 助教 (10441726)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 大豆イソフラボン / 乳癌 / 抗癌機序 / 癌予防機序 / 併用添加 / ゲニステイン / エクオール / アポトーシス / 乳癌モデルラット / がん遺伝子 / 併用効果 |
|---|
| Outline of Final Research Achievements |
We investigated the anticancer activity of soy isoflavones, genistein (GEN), daidzein, glycitein and equol, a metabolite of daidzein, and their interaction in three human breast cancer cell lines that differ in their receptor status. Synergistic interactions between GEN and equol were strongest than those between GEN and other isoflavone components, with significant synergy observed in MCF-7 cells. At the molecular level, synergistic interaction of GEN and equol combination appears to be brought by apoptosis induction through elevation of Bax/Bcl-xl expression ratio, thus providing mechanistic rationale for isoflavones for the prevention of ER-positive human breast cancer for Asian women who are more capable than Western women of converting daidzein to equol. Genistein-containing diet supplemented with equol could not delay the development of mammary carcinoma, showing any preventive activity. Currently, we are continuing animal experiments with modification of isoflavone doses.
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Report
(4 results)
Research Products
(45 results)
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[Presentation] 心音測定を応用した運動療法が肥満女性の体力ならびに動脈硬化危険因子に及ぼす効果2015
Author(s)
熊原秀晃, 上野宏美, 一田木綿子, 小野美咲, 宮崎瞳, 飛奈卓郎, 道下竜馬, 森村和浩, 塩瀬圭佑, 畑本陽一, 田中宏暁, 中野修治
Organizer
第36回日本肥満学会
Place of Presentation
名古屋 名古屋国際会議場
Year and Date
2015-10-03
Related Report
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[Presentation] 肥満中年女性におけるゆるやかな減量の効果2014
Author(s)
五郎丸瞭子, 岩本昌子, 中尾晶子, 宮崎瞳, 今井克己, 阿部志麿子, 森口里利子, 津田博子, 中園栄里, 小野美咲, 上野宏美, 中野修治
Organizer
第61回日本栄養改善学会学術総会
Place of Presentation
横浜
Year and Date
2014-08-21
Related Report
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[Presentation] 卒業10年後の健診結果に影響を及ぼす大学在学時の食事因子―卒後追跡調査から―2014
Author(s)
上野宏美, 宮崎瞳, 今井克己, 阿部志磨子, 増田隆, 森口里利子, 津田博子, 岩本昌子, 中園栄里, 小野美咲, 森山耕成, 大部正代, 大無田恵美, 岩本華奈, 五郎丸瞭子, 中野修治
Organizer
第68回日本栄養・食糧学会大会
Place of Presentation
札幌
Year and Date
2014-06-01
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