• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Fundamental study on artificial control of glucose and lipid metabolism with microstimulation of peripheral sympathetic nerve fascicle

Research Project

Project/Area Number 26750141
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionYamagata University

Principal Investigator

Sato Daisuke  山形大学, 大学院医学系研究科, 助教 (60536960)

Research Collaborator NAKAMURA Takao  山形大学, 大学院医学系研究科, 教授 (00142654)
KUSUNOKI Masataka  名古屋大学, 総合保健体育科学センター, 寄附研究部門教授 (80214956)
NISHINA Atsuyoshi  日本大学, 理工学部, 教授 (00469884)
TSUTSUMI Kazuhiko  徳島文理大学, 薬学部, 特任教授
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords末梢交感神経 / 糖取り込み / 脂肪酸組成 / インスリン / インスリン感受性 / Microstimulation
Outline of Final Research Achievements

To develop the novel method for artificial control of glucose and lipid metabolism without exercise and drug, we investigated the effects of microstimulation of peripheral sympathetic nervous system on glucose and lipid metabolism. As a result of the microstimulation of sympathetic nerve fascicle in the unilateral sciatic nerve in rats, the stimulation enhanced systemic glucose uptake without change in plasma insulin level. In addition, the stimulation for 1 h elevated gene expression of Cox4 in epididymal adipose tissue in rats, suggesting increase in mitochondria. In conclusion, the microstimulation of peripheral sympathetic nerve fascicle enhanced non-insulin-mediated glucose uptake systemically and fat oxidation in adipose tissue.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (9 results)

All 2016 2015 2014

All Journal Article (1 results) Presentation (8 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] ラット坐骨神経内交感神経束へのmicrostimulationが対側交感神経活動に与える効果2014

    • Author(s)
      中村嶺一,塩飽裕,小泉俊太郎,佐藤大介,楠正隆,中村孝夫
    • Journal Title

      第14回山形ニューロサイエンス研究会会誌

      Volume: 14 Pages: 19-22

    • Related Report
      2014 Research-status Report
  • [Presentation] 脂肪組織中脂肪酸組成に及ぼすラット末梢交感神経束電気刺激の影響2016

    • Author(s)
      本澤俊明, 佐藤大介, 佐々木寛之, 楠正隆, 中村孝夫
    • Organizer
      第37回日本肥満学会
    • Place of Presentation
      東京ファッションタウン(東京都江東区)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Electrical stimulation of peripheral sympathetic nerve fascicle enhances non-insulin-mediated glucose uptake in rats2016

    • Author(s)
      Sato D, Yamaguchi R, Sasaki H, Kusunoki M, Feng Z, Nakamura T
    • Organizer
      American Diabetes Association 76th Scientific Sessions
    • Place of Presentation
      Ernest N. Morial Convention Center (New Orleans, LA, USA)
    • Year and Date
      2016-06-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ラット末梢交感神経束microstimulationは骨格筋糖取り込み関連遺伝子の発現に影響を及ぼさない2016

    • Author(s)
      佐藤大介, 阿部泰樹, 楠正隆, 中村孝夫
    • Organizer
      第29回日本マイクロニューログラフィ学会
    • Place of Presentation
      東京大学山上会館(東京都文京区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] ラット片側坐骨神経内交感神経束へのmicrostimulationが糖代謝へ及ぼす影響2015

    • Author(s)
      山口陸, 阿部泰樹, 佐藤大介, 楠正隆, 中村孝夫
    • Organizer
      第53回日本人工臓器学会大会
    • Place of Presentation
      東京ドームホテル(東京都文京区)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Research-status Report
  • [Presentation] Effects of microstimulation of a peripheral sympathetic nerve fascicle on blood glucose and insulin sensitivity in rats2015

    • Author(s)
      Sato D, Yamaguchi R, Sasaki H, Kusunoki M, Feng Z, Nakamura T
    • Organizer
      8th Asia-Oceania Conference on Obesity
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ラット末梢交感神経束内microstimulationのインスリン感受性に及ぼす影響2015

    • Author(s)
      山口陸, 小泉俊太郎, 白土貴也, 佐藤大介, 楠正隆, 中村孝夫
    • Organizer
      第28回日本マイクロニューログラフィ学会
    • Place of Presentation
      山形大学医学部(山形市)
    • Year and Date
      2015-06-20
    • Related Report
      2015 Research-status Report
  • [Presentation] ラット末梢交感神経束へのmicrostimulationの性質2014

    • Author(s)
      佐藤大介,楠正隆,中村孝夫
    • Organizer
      第67回日本自律神経学会総会
    • Place of Presentation
      ラフレさいたま(埼玉県さいたま市)
    • Year and Date
      2014-10-30 – 2014-10-31
    • Related Report
      2014 Research-status Report
  • [Presentation] ラット末梢交感神経束内microstimulationが血糖値に及ぼす効果2014

    • Author(s)
      山口陸,中村嶺一,小泉俊太郎,佐藤大介,楠正隆,中村孝夫
    • Organizer
      第53回日本生体医工学会大会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2014-06-24 – 2014-06-26
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi