| Project/Area Number |
26750142
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YUASA Tetsuya 山形大学, 大学院理工学研究科, 教授 (30240146)
SUNAGUCHI Naoki 北里大学, 医療衛生学部, 教授 (10197311)
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| Research Collaborator |
Sasaya Tenta
Murozuka Makoto
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 蛍光X線 / CT / 放射光Ｘ線 / 蛍光Ｘ線 / 小動物分子イメージング / 放射光X線 / 蛍光X線CT |
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| Outline of Final Research Achievements |
We propose a fluorescent x-ray computed tomography based on multiple pinholes (pFXCT) for preclinical molecular imaging. The proposed method simultaneously acquires multiple projections for a single view through the multi-pinhole collimator with a two-dimensional detector and a full-field volumetric beam to speed up data acquisition and to enhance the signal-to-noise ratio of projections. We constructed an pFXCT imaging system having fifteen pinholes at beamline ARNE-7A in KEK and performed preliminary experiments to investigate its imaging properties using physical phantoms including non-radioactive iodine imaging agent. The pFXCT attained a minimum detectable concentration of 38 I ug/ml required for in-vivo imaging at a spatial resolution of about 300 um for a data-acquisition time of 90 min less than an effective time of anesthesia, which suggests that preclinical molecular imaging is feasible with pFXCT.
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