Development of fluorescent X-ray computed tomography using multi pinhole collimator
| Project/Area Number |
26750142
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YUASA Tetsuya 山形大学, 大学院理工学研究科, 教授 (30240146)
SUNAGUCHI Naoki 北里大学, 医療衛生学部, 教授 (10197311)
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| Research Collaborator |
Sasaya Tenta
Murozuka Makoto
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 蛍光X線 / CT / 放射光Ｘ線 / 蛍光Ｘ線 / 小動物分子イメージング / 放射光X線 / 蛍光X線CT |
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| Outline of Final Research Achievements |
We propose a fluorescent x-ray computed tomography based on multiple pinholes (pFXCT) for preclinical molecular imaging. The proposed method simultaneously acquires multiple projections for a single view through the multi-pinhole collimator with a two-dimensional detector and a full-field volumetric beam to speed up data acquisition and to enhance the signal-to-noise ratio of projections. We constructed an pFXCT imaging system having fifteen pinholes at beamline ARNE-7A in KEK and performed preliminary experiments to investigate its imaging properties using physical phantoms including non-radioactive iodine imaging agent. The pFXCT attained a minimum detectable concentration of 38 I ug/ml required for in-vivo imaging at a spatial resolution of about 300 um for a data-acquisition time of 90 min less than an effective time of anesthesia, which suggests that preclinical molecular imaging is feasible with pFXCT.
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Report
(4 results)
Research Products
(37 results)
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[Presentation] Researches on physical problems in heavy ion radiation therapy2014
Author(s)
T. Kanai, N. Sunaguchi, A. Matsumura, M. Kawashima, Y. Kubota, H. Souda, M. Sakai, H. Sakurai, Y. Yamakoshi, A. Kada, S. Hosaka, K. Yamada, O. Hanaizumi
Organizer
1st International Symposium of Gunma University Medical Innovation (GUMI) and 6th International Conference on Advanced Micro-Device Engineering (AMDE)
Place of Presentation
桐生市市民文化会館（群馬県桐生市)
Year and Date
2014-12-05
Related Report
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[Presentation] Developing of a Compton scatter imaging instrument2014
Author(s)
4.D. Kato, A. Nagao, N. Sunaguchi, Y. Yamakoshi, T. Kanai, K. Suzuki, A. Matsumura, M. Kawashima, H. Sakurai
Organizer
1st International Symposium of Gunma University Medical Innovation (GUMI) and 6th International Conference on Advanced Micro-Device Engineering (AMDE)
Place of Presentation
桐生市市民文化会館（群馬県桐生市)
Year and Date
2014-12-05
Related Report
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