| Project/Area Number |
26750144
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MONTAGNE Kevin 東京大学, 工学(系)研究科(研究院), 助教 (50606118)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | Hypoxia / Biomaterials / Tissue engineering |
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| Outline of Final Research Achievements |
Engineering thick, cell-dense artificial tissues to replace diseased organs has been hindered so far by the difficulty in maintaining the cells alive after implantation due to insufficient oxygen supply. The aim of this research was to create thick tissue constructs based on oxygen-releasing biomaterials that both promote blood vessel growth upon implantation into a host while simultaneously releasing oxygen to maintain the viability of the construct.
So far, oxygen-releasing biomaterials have been prepared consisting of polydimethylsiloxane sponges containing up to 20% of calcium peroxide. Those sponges have been shown to increase the oxygen concentration in the cell culture medium. Furthermore, cells cultured at a high density in the sponges were still viable after up to seven days in culture and showed a decreased hypoxic response compared to cells cultured in control materials
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