| Project/Area Number |
26750147
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Osaka University |
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Principal Investigator |
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| Research Collaborator |
NOMURA Taishin 大阪大学, 大学院基礎工学研究科, 教授
SAKODA Saburo 国立病院機構刀根山病院, 院長
KIYONO Ken 大阪大学, 大学院基礎工学研究科, 准教授
ENDO Takuyuki 国立病院機構刀根山病院, 神経内科, 医師
TANAHASHI Takao 市立東大阪医療センター, 神経内科, 部長
FU Chunjiang 大阪大学, 大学院基礎工学研究科, 研究員
YAMAMOTO Tomohisa 大阪大学, 大学院基礎工学研究科
YOSHIKAWA Naoya 大阪大学, 大学院基礎工学研究科
MORIMOTO Hiroki 大阪大学, 大学院基礎工学研究科
INOUE Takuya 大阪大学, 大学院基礎工学研究科
MATSUDA Kazuyuki 大阪大学, 大学院基礎工学研究科
MICHIMOTO Kenjiro 大阪大学, 大学院基礎工学研究科
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 姿勢制御 / 間欠制御 / パーキンソン病 / 姿勢動揺 / 間欠制御仮説 / サドル型不安定 / 関節間協調運動 / UnControlled Manifold |
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| Outline of Final Research Achievements |
During quiet standing, human body joints show flexible and coordinated movement. In this study, we analyzed experimental postural sway data obtained from healthy young subject, and showed that the flexible and coordinated joint movement are based on skillful usage of intrinsic property of human body. We also measured Center of Pressure (CoP) during quiet stance from patients with Parkinson's disease and age matched healthy elderly. We performed a linear discriminant analysis and showed that CoP variations in Parkinson's disease patients and those in healthy elderly could be well distinguished with an accuracy of about 90%. Major factors responsible for the discrimination were associated with power at frequency band, and our results suggested that diminution of flexible anti-phase coordination leads postural instability in Parkinson's disease patients.
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