Synthesis of aligned megadalton hemoglobin assembly as artificial oxygen carrier
| Project/Area Number |
26750149
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Research Collaborator |
SAKAI Hiromi
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 人工臓器学 / 血液代替物 / 高分子 / ヘモグロビン |
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| Outline of Final Research Achievements |
There have been many attempts to make artificial oxygen carriers based on the modification of isolated hemoglobin (Hb). In these attempts, artificial oxygen carrier realizes improved characteristics, avoiding infection, no blood type, and longer shelf life than red blood cells (RBC). In this work, novel large-sized Hb assembly (aligned megadalton Hb; AM-Hb) was synthesized by intermolecular crosslinking of Hbs with 4-armed polyethylene glycol (PEG) to prevent extravasation.
The physicochemical properties as oxygen carrier was evaluated for AM-Hb. The molecular size of AM-Hb depends on the molecular weight of PEG linker. AM-Hb has larger viscosity and larger oxygen affinity than those of RBC, Hb, and Hb vesicles.
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Report
(4 results)
Research Products
(4 results)
