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Chronic electrical activation of the arterial baroreflex in hypertensive rats - determining the role of unmyelinated baroreceptors

Research Project

Project/Area Number 26750153
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

Turner Michael  国立研究開発法人国立循環器病研究センター, 研究所, 流動研究員 (90714204)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsbaroreflex / sympathetic system / arterial pressure / hypertension / electrical stimulation / aortic depressor nerve / myelinated fibers / unmyelinated fibers / Baroreflex / Hypertension / Resiniferatoxin / Capsaicin / Nerve Stimulation / resiniferatoxin / capsaicin / nerve stimulation
Outline of Final Research Achievements

Resistant hypertension is defined as blood pressure that remains above goal in spite of the concurrent use of three different types of antihypertensive agents. Development of new treatment strategies for drug-resistant hypertension is needed. Baroreflex activation therapy (BAT), which stimulates the arterial baroreflex system to reduce sympathetic nerve activity and arterial pressure, is one of non-pharmacological treatmenmts. However, there are responders and non-responders to BAT, and the further understanding of the mechanism of BAT is required to predict the outcome. We explored how BAT decreased arterial pressure from a viewpoint of differences between unmyelinated and myelinated baroreceptor fibers using a rat model of chronic hypertension.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (22 results)

All 2016 2015 2014

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Acknowledgement Compliant: 4 results,  Open Access: 2 results) Presentation (12 results) (of which Invited: 2 results)

  • [Journal Article] Development of a servo pump system for in vivo loading of pathological pulmonary artery impedance on the right ventricle of normal rats.2016

    • Author(s)
      Fukumitsu M, Kawada T, Shimizu S, Turner MJ, Uemura K, Sugimachi M
    • Journal Title

      American Journal of Physiology: Heart and Circulatory Physiology

      Volume: 310 Issue: 8 Pages: 973-983

    • DOI

      10.1152/ajpheart.00813.2015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systematic understanding of acute effects of intravenous guanfacine on rat carotid sinus baroreflex-mediated sympathetic arterial pressure regulation2016

    • Author(s)
      Kawada T, Shimizu S, Turner MJ, Fukumitsu M, Yamamoto H, Sugimachi M
    • Journal Title

      Life Sci.

      Volume: 149 Pages: 72-78

    • DOI

      10.1016/j.lfs.2016.02.051

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Partial cavopulmonary assist from the inferior vena cava to the pulmonary artery improves hemodynamics in failing Fontan circulation: a theoretical analysis.2016

    • Author(s)
      Shimizu S, Kawada T, Une D, Fukumitsu M, Turner MJ, Kamiya A, Shishido T, Sugimachi M.
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 66 Issue: 3 Pages: 249-255

    • DOI

      10.1007/s12576-015-0422-3

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences in the dynamic baroreflex characteristics of unmyelinated and myelinated central pathways are less evident in spontaneously hypertensive rats2015

    • Author(s)
      Turner MJ, Kawada T, Shimizu S, Fukumitsu M, Sugimachi M
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol.

      Volume: 309 Issue: 11 Pages: 1397-1405

    • DOI

      10.1152/ajpregu.00315.2015

    • NAID

      130005163756

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Open-loop characteristics of the arterial baroreflex after blockade of unmyelinated baroreceptors with resiniferatoxin2015

    • Author(s)
      Turner MJ, Kawada T, Shimizu S, Fukumitsu M, Sugimachi M
    • Journal Title

      Auton Neurosci.

      Volume: 193 Pages: 38-43

    • DOI

      10.1016/j.autneu.2015.05.008

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of tempol on baroreflex neural arc versus peripheral arc in normotensive and spontaneously hypertensive rats2015

    • Author(s)
      Kawada T, Sata Y, Shimizu S, Turner MJ, Fukumitsu M, Sugimachi M
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 未定 Issue: 11 Pages: 957-964

    • DOI

      10.1152/ajpregu.00525.2014

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Acute effects of intravenous nifedipine or azelnidipine on open-loop baroreflex static characteristics in rats2015

    • Author(s)
      Hiromi Yamamoto, Toru Kawada, Shuji Shimizu, Atsunori Kamiya, Michael J. Turner, Shunichi Miyazaki, Masaru Sugimachi
    • Journal Title

      Life Sciences

      Volume: 126 Pages: 37-41

    • DOI

      10.1016/j.lfs.2015.01.024

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Calibration of baroreflex equilibrium diagram based on exogenous pressor agents in chronic heart failure rats2015

    • Author(s)
      Kawada T, Li M, Sata Y, Zheng C, Turner MJ, Shimizu S, Sugimachi M
    • Journal Title

      Clin Med Insights Cardiol

      Volume: 9(Suppl 1) Pages: 1-9

    • DOI

      10.4137/cmc.s18759

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Guanfacine enhances cardiac acetylcholine release with little effect on norepinephrine release in anesthetized rabbits.2015

    • Author(s)
      Shimizu S, Kawada T, Akiyama T, Turner MJ, Shishido T, Kamiya A, Shirai M, Sugimachi M.
    • Journal Title

      Autonomic Neuroscience

      Volume: 187 Pages: 84-87

    • DOI

      10.1016/j.autneu.2014.11.010

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute Effects of Arterial Baroreflex on Sympathetic Nerve Activity and Plasma Norepinephrine Concentration2014

    • Author(s)
      Kawada T, Akiyama T, Shimizu S, Sata Y, Turner MJ, Shirai M and Sugimachi M
    • Journal Title

      Autonomic Neuroscience

      Volume: 186 Pages: 62-68

    • DOI

      10.1016/j.autneu.2014.10.016

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Electrical baroreflex activation does not impede native short-term baroreflex regulation: Evidence from an animal model of hypertension2016

    • Author(s)
      Turner MJ, Shimizu S, Kawada T, Fukumitsu M, Sugimachi M
    • Organizer
      The 80th Annual Scientifc Meeting of the Japanese Circulation Society
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 正常血圧および高血圧自然発症ラットにおいて、大動脈減圧神経の電気刺激は動脈圧反射の動特性に影響を与えない2015

    • Author(s)
      ターナーマイケル, 川田 徹, 清水秀二, 杉町 勝
    • Organizer
      第108回近畿生理学談話会
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] メデトミジンは大動脈減圧神経刺激による心臓アセチルコリン分泌を増強する2015

    • Author(s)
      清水秀二, 川田 徹, 秋山 剛, ターナーマイケル, 福満雅史, 神谷厚範, 宍戸稔聡, 杉町 勝
    • Organizer
      第36回日本循環制御医学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] Identification of dynamic characteristics of the baroreflex neural arc in spontaneously hypertensive rats and its implication to baroreflex activation therapy2015

    • Author(s)
      Turner MJ, Kawada T, Sugimachi M
    • Organizer
      第2回ニューロネットワークと循環研究会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Differences in dynamic baroreflex characteristics of unmyelinated and myelinated central pathways are less evident in spontaneously hypertensive rats2015

    • Author(s)
      Turner MJ, Kawada T, Sugimachi M
    • Organizer
      The 54th annual conference of Japanese Society for Medical and Biological Engineering
    • Place of Presentation
      名古屋
    • Year and Date
      2015-05-07
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Nonlinear central processing in the carotid sinus baroreflex evokes directional sensitivity to input pressure waveform2015

    • Author(s)
      Kawada T, Shimizu S, Li M, Turner MJ, Fukumitsu M, Zheng C, Sugimachi M
    • Organizer
      第79回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Electrical baroreflex activation does not impede native short-term baroreflex via central interaction: Evidence from an animal study2015

    • Author(s)
      Turner MJ, Shimizu S, Kawada T, Fukumitsu M, Sugimachi M
    • Organizer
      The 79 Annual Scientifc Meeting of the Japanese Circulation Society
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 高血圧自然発症ラットにおける動脈圧反射中枢弓の動特性2014

    • Author(s)
      川田 徹, ターナー マイケル, 杉町 勝
    • Organizer
      第50回高血圧関連疾患モデル学会学術総会
    • Place of Presentation
      和歌山
    • Year and Date
      2014-12-05 – 2014-12-06
    • Related Report
      2014 Research-status Report
  • [Presentation] 左心低形成症候群に対するハイブリッド手術の血行動態シミュレーション2014

    • Author(s)
      清水秀二, 川田 徹, マイケル J ターナー, 宍戸稔聡, 杉町 勝
    • Organizer
      第107回近畿生理学談話会
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-25
    • Related Report
      2014 Research-status Report
  • [Presentation] Dynamic carotid baroreflex characteristics are unaffected by the electrical stimulation of aortic baroreceptors2014

    • Author(s)
      Turner MJ, Shimizu S, Kawada T, Sugimachi M
    • Organizer
      第107回近畿生理学談話会
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-25
    • Related Report
      2014 Research-status Report
  • [Presentation] Static characteristics of the aortic baroreflex following blockade of unmyelinated baroreceptor activity with resiniferatoxin2014

    • Author(s)
      Turner MJ, Kawada T, Sugimachi M
    • Organizer
      Life Engineering Symposium 2014
    • Place of Presentation
      金沢
    • Year and Date
      2014-09-17 – 2014-09-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 交感神経活動と血中ノルアドレナリンの関係は直線的か?2014

    • Author(s)
      川田 徹, 清水秀二, 李 梅花, ターナー マイケル, 秋山 剛, 杉町 勝
    • Organizer
      第35回日本循環制御医学会総会
    • Place of Presentation
      博多
    • Year and Date
      2014-07-04 – 2014-07-05
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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