Therapeutic approach to lysosomal storage disorders by brain-targetable supramolecular prodrugs
| Project/Area Number |
26750155
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Biomedical engineering/Biomaterial science and engineering
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
Tamura Atsushi 東京医科歯科大学, 生体材料工学研究所, 助教 (80631150)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | ポリロタキサン / シクロデキストリン / コレステロール / ライソゾーム病 / ニーマンピック病C型 / オートファジー / 酸化ステロール / リソソーム |
|---|
| Outline of Final Research Achievements |
In this study, stimuli-labile polyrotaxanes containing β-cyclodextrins were developed for the treatment of Niemann-Pick type C (NPC) disease. The administration of the polyrotaxane significantly prolonged the life span of the mouse model of NPC disease at lower dose than clinically tested β-cyclodextrin derivatives. Accordingly, the polyrotaxanes are promising candidate for the treatment of NPC disease.
|
Report
(4 results)
Research Products
(51 results)
-
-
-
-
-
-
-
-
[Journal Article] 人工材料（有機）2015
Author(s)
田村篤志
-
Journal Title
Jinko Zoki
Volume: 44
Issue: 3
Pages: 169-172
DOI
NAID
ISSN
0300-0818, 1883-6097
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Heparin-mimicking supermolecules for enhancing supramolecular polyrotaxane enhances osteoinduction ability of with bone morphogenetic protein-22015
Author(s)
Masahiko Terauchi, Takasuke Inada, Tomoki Kanemaru, Kei Nishida, Atsushi Tamura, Satoshi Yamaguchi, Kiyoshi Harada, Nobuhiko Yui
Organizer
International Chemical Congress of Pacific Basin Societies (Pacifichem2015)
Place of Presentation
Hawaii Convention Center, Honolulu, Hawaii, USA
Year and Date
2015-12-15
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
