| Project/Area Number |
26750155
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Tamura Atsushi 東京医科歯科大学, 生体材料工学研究所, 助教 (80631150)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ポリロタキサン / シクロデキストリン / コレステロール / ライソゾーム病 / ニーマンピック病C型 / オートファジー / 酸化ステロール / リソソーム |
|---|
| Outline of Final Research Achievements |
In this study, stimuli-labile polyrotaxanes containing β-cyclodextrins were developed for the treatment of Niemann-Pick type C (NPC) disease. The administration of the polyrotaxane significantly prolonged the life span of the mouse model of NPC disease at lower dose than clinically tested β-cyclodextrin derivatives. Accordingly, the polyrotaxanes are promising candidate for the treatment of NPC disease.
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