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Neuroregeneration by concerted regulation of cellular microenvironments

Research Project

Project/Area Number 26750156
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Hashimoto Yoshihide  東京医科歯科大学, 生体材料工学研究所, 助教 (40638384)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsナノゲル / 細胞微小環境 / 神経再生 / グリコサミノグリカン / 組織工学 / エキソソーム / 多糖 / 成長因子 / ナノマトリクス
Outline of Final Research Achievements

The purpose of this study is to develop the nano-matrix that mimicked cellular microenvironments for regeneration of injured neural tissues. We established the synthetic method of methacryloyl group- and cholesteryl group- bearing chondroitin sulfate (CH-GAG-MA), and successfully developed novel nanogels. We also developed the nano-matrix complexed with proteins and exosomes using CH-GAG-MA nanogels as building blocks.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (13 results)

All 2016 2015 2014 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 1 results,  Open Access: 1 results) Presentation (6 results) Remarks (2 results)

  • [Journal Article] Advanced artificial extracellular matrices using amphiphilic nanogel-cross-linked thin films to anchor adhesion proteins and cytokines2016

    • Author(s)
      Y. Hashimoto, S. Mukai, S. Sawada, T. Sasaki, K. Akiyoshi
    • Journal Title

      ACS Biomaterials Science & Engineering

      Volume: 2 Issue: 3 Pages: 375-384

    • DOI

      10.1021/acsbiomaterials.5b00485

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of a polysaccharide nanogel-crosslinked membraneon wound healing2016

    • Author(s)
      Hiroki Maeda,Hiroshi Kobayashi,Takayuki Miyahara,Yoshihide Hashimoto,Kazunari Akiyoshi,Shohei Kasugai
    • Journal Title

      Jouranal of Biomedical Materials research Part B Applied Materials

      Volume: 未定 Issue: 3 Pages: 554-560

    • DOI

      10.1002/jbm.b.33571

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nanogel tectonic porous gel loading biologics, nanocarriers, and cells for advanced scaffold2015

    • Author(s)
      Y. Hashimoto, S. Mukai,S. Sawada, Y. Sasaki, K. Akiyoshi
    • Journal Title

      Biomaterials

      Volume: 37 Pages: 107-115

    • DOI

      10.1016/j.biomaterials.2014.10.045

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cycloamylose-Nanogel DDS-mediated intratumor silencing of the vascular endothelial growth factor regulates neovascularization in tumor microenvironment2014

    • Author(s)
      H. Fujii, M. Shin-Ya, S. Takeda, Y. Hashimoto, S. Mukai, S. Sawada, T. Adachi, K. Akiyoshi, T. Miki, O. Mazda
    • Journal Title

      Cancer Science

      Volume: 105 Issue: 12 Pages: 1616-1625

    • DOI

      10.1111/cas.12547

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Therapeutic Effect of Nanogel-Based Delivery of Soluble FGFR2 with S252W Mutation on Craniosynostosis2014

    • Author(s)
      M. Yokota, Y. Kobayashi, J. Morita, H. Suzuki, Y. Hashimoto, Y. Sasaki, K. Akiyoshi, K. Moriyama
    • Journal Title

      PLOS ONE

      Volume: 9 Issue: 7 Pages: e101693-e101693

    • DOI

      10.1371/journal.pone.0101693

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 有機-無機ハイブリッドポーラス材料の設計と再生医療応用2015

    • Author(s)
      藤原理絵, 橋本良秀, 丸川恵理子, 澤田晋一, 向井貞篤, 佐々木善浩, 秋吉一成
    • Organizer
      第37回日本バイオマテリアル学会大会
    • Place of Presentation
      京都テルサ(京都府, 京都市)
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 有機-無機ハイブリッドポーラス材料の設計と医療応用2015

    • Author(s)
      藤原理絵, 橋本良秀, 丸川恵理子, 澤田晋一, 向井貞篤, 佐々木善浩, 秋吉一成
    • Organizer
      第64回高分子討論会
    • Place of Presentation
      東北大学川内キャンパス(宮城県, 仙台市)
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] ナノゲルテクトニクス材料:ナノゲル架橋ハイブリッド フィルムの創製と機能評価2015

    • Author(s)
      向井貞篤, 橋本良秀, 田原義朗, 澤田晋一, 秋吉一成
    • Organizer
      第64回高分子学会年次大会
    • Place of Presentation
      札幌コンベンションセンター(北海道, 札幌市)
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 多糖ナノボールの集積制御に基づく新規ゲル材料の設計とバイオマテリアル応用2015

    • Author(s)
      沖田圭司, 竹田茂生, 橋本良秀, 向井貞篤, 澤田晋一, 佐々木善浩, 秋吉一成
    • Organizer
      第64回高分子学会年次大会
    • Place of Presentation
      札幌コンベンションセンター(北海道, 札幌市)
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 多孔質構造を有するナノゲル架橋ハイブリッドゲルの開発と機能評価2014

    • Author(s)
      橋本良秀、向井貞篤、澤田晋一、秋吉一成
    • Organizer
      第63回高分子討論会
    • Place of Presentation
      長崎
    • Year and Date
      2014-09-24 – 2014-09-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Fabrication of nanogel-crosslinked porous gels for tissue engineering applications2014

    • Author(s)
      Yoshihide Hashimoto, Sada-atsu Mukai, Shin-ichi Sawada, Kazunari Akiyoshi
    • Organizer
      The 41st Annual Meeting & Exposition of the Controlled Release Society
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2014-07-13 – 2014-07-16
    • Related Report
      2014 Research-status Report
  • [Remarks] 京都大学 秋吉研究室

    • URL

      http://www.akiyoshi-lab.jp/

    • Related Report
      2015 Annual Research Report
  • [Remarks] ERATO秋吉プロジェクト

    • URL

      http://www.jst.go.jp/erato/akiyoshi/index.html

    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2017-05-10  

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