Neuroregeneration by concerted regulation of cellular microenvironments
| Project/Area Number |
26750156
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ナノゲル / 細胞微小環境 / 神経再生 / グリコサミノグリカン / 組織工学 / エキソソーム / 多糖 / 成長因子 / ナノマトリクス |
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| Outline of Final Research Achievements |
The purpose of this study is to develop the nano-matrix that mimicked cellular microenvironments for regeneration of injured neural tissues. We established the synthetic method of methacryloyl group- and cholesteryl group- bearing chondroitin sulfate (CH-GAG-MA), and successfully developed novel nanogels. We also developed the nano-matrix complexed with proteins and exosomes using CH-GAG-MA nanogels as building blocks.
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Report
(3 results)
Research Products
(13 results)
