| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
I developed a hollow mesoporous silica (HMS) nanosphere adjuvant in this study. The plain HMS nanosphere, without any immunomodulatory molecules, markedly improved anti-tumor immunity, significantly improved both Th1 and Th2 immunity, and significantly improved effector memory CD4+ and CD8+ T cell population in bone marrow in vivo. Moreover, we loaded fluorescence substance with the HMS nanospheres. These HMS nanospheres were visible under fluorescence microscope, IVIS imaging system and ultrasonic.
The HMS nanospheres showed smooth surface, uniform diameter about 200 nm, and shell thickness about 30-40 nm. The shell of the HMS nanospheres showed mesopores about 3-6 nm. The porous structure in this material is crucial for antigen adsorption and delivery, antigen cellular uptake, antigen cross-presentation, immune-related cytokines secretion, and anti-cancer immunity stimulation. The developed HMS nanospheres may be used as human cancer immunoadjuvant.
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