| Project/Area Number |
26750165
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical systems
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | POCT / ラマン分光 / 薬物モニタリング / Point-of-Care Testing |
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| Outline of Final Research Achievements |
Therapeutic drug monitoring (TDM) that can be performed near the patient is helpful for safe and effective pharmacotherapy. This study aims to realize rapid TDM that does not require blood sampling. For this purpose, paper-based Raman spectroscopy of tear fluid is proposed for on-site TDM. The paper substrates are used for tear sample collection and measurement. The use of paper offers a minimally invasive, simple, and inexpensive method for therapeutic drug monitoring. As a prototype demonstration, paper-based SERS substrates were fabricated with filter papers and gold nanorods. Experimental results show that the Raman signals of a target therapeutic drug in artificial tear fluid were enhanced with the fabricated substrates. This indicates that the proposed approach is led to on-site TDM.
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