Impact of exercise therapy on oxidative stress in patients with peripheral artery disease

• Project/Area Number: 26750181
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Shinshu University
• Principal Investigator: YAMASAKI Saeko 信州大学, 学術研究院医学系(医学部附属病院), 助教 (50623914)
• Research Collaborator: EBISAWA Soichiro 信州大学, 医学部附属病院, 講師(特定雇用) (50645439) ; KASHIMA Yuichiro 信州大学, 学術研究院医学系(医学部附属病院), 助教 (70545722) ; IKEDA Uichi 信州大学, 医学部, 特任教授 (30221063) ; KUWAHARA Koichiro 信州大学, 学術研究院医学系, 教授 (30402887) ; AONO Minako 信州大学, 医学部附属病院, 技術補佐員
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 循環器、高血圧 / 心臓リハビリテーション / 運動療法 / 福祉 / 閉塞性動脈硬化症 / 循環器内科 / 高血圧 / 循環器・高血圧 / リハビリテーション

Outline of Final Research Achievements

Peripheral artery disease (PAD) is an atherosclerotic disease. PAD patients often have other cardiovascular disease and poor prognosis. Exercise is effective for claudication and prognosis of patients with PAD. Few hospitals give supervised exercise therapy for PAD and report why exercise is effective for PAD. This study enrolled twenty five PAD patients with claudication. The levels of diacron-reactive oxygen metabolite (d-ROM: an oxidative stress marker), ankle-brachial index (ABI), and maximum walking distance at baseline and at 3 months after endovascular therapy (EVT) were measured. As compared with baseline values, the maximum walking distance, ABI and d-ROM improved significantly after EVT (109.9±104.2 vs. 313.7±271.8 m; 0.61±0.15 vs. 0.91±0.13; 472.8±64.8 vs. 390.2 ±46.7 U.CARR).
We encouraged supervised exercise therapy and explained their effect. We succeeded in increasing cardiac rehabilitation.

Research Products

• [Journal Article] A 2-year follow-up of oxidative stress levels in patients with ST-segment elevation myocardial infarction: a subanalysis of the ALPS-AMI study. (2015)
  • Author(s): Abe N, Kashima Y, Izawa A, Motoki H, Ebisawa S, Miyashita Y, Imamura H, Ikeda U.
  • Journal Title: Angiology Volume: 66(3) Issue: 3 Pages: 271-277
  • DOI: 10.1177/0003319714525656
  • Peer Reviewed / Open Access
• [Journal Article] Association between estimated glomerular filtration rate and peripheral arterial disease. (2015)
  • Author(s): Yamasaki S, Izawa A, Koshikawa M, Saigusa T, Ebisawa S, Miura T, Shiba Y, Tomita T, Miyashita Y, Koyama J, Ikeda U.
  • Journal Title: Journal of Cardiology Volume: 66 Issue: 5 Pages: 430-434
  • DOI: 10.1016/j.jjcc.2015.01.011
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic improvement by multidisciplinary therapy in patients with critical limb ischemia. (2015)
  • Author(s): Hioki H, Miyashita Y, Miura T, Ebisawa S, Motoki H, Izawa A, Tomita T, Koyama J, Ikeda U.
  • Journal Title: Angiology Volume: 66(2) Issue: 2 Pages: 187-194
  • DOI: 10.1177/0003319714523113
  • Peer Reviewed / Open Access
• [Journal Article] Five-year prognosis after endovascular therapy in claudicant patients with iliofemoral artery disease (2014)
  • Author(s): Miura T, Soga Y, Miyashita Y, Iida O, Kawasaki D, Hirano K, Ikeda U.
  • Journal Title: J Endovasc Ther Volume: 21 Issue: 3 Pages: 381-388
  • DOI: 10.1583/13-4618r.1
  • Peer Reviewed / Open Access
• [Journal Article] Impact of endovascular therapy on oxidative stress in patients with peripheral artery disease. (2014)
  • Author(s): Ebisawa S, Kashima Y, Miyashita Y, Yamazaki S, Abe N, Saigusa T, Miura T, Motoki H, Izawa A, Ikeda U.
  • Journal Title: Circ J Volume: 78(6) Pages: 1445-1450
  • NAID: 130003391109
  • Peer Reviewed
• [Journal Article] Diagnostic value of peripheral fractional flow reserve in isolated iliac artery stenosis : A comparison with the post-exercise ankle-brachial index (2014)
  • Author(s): Hioki H, Miyashita Y, Miura T, Ebisawa S, Motoki H, Izawa A, Tomita T, Koyama J, Ikeda U
  • Journal Title: J Endovasc Ther Volume: 21 Issue: 5 Pages: 625-632
  • DOI: 10.1583/14-4734mr.1
  • Peer Reviewed / Open Access
• [Presentation] Utility of a Clinical Pathway for Patients Implanted Ventricular Assist Device (2016)
  • Author(s): Yamasaki S
  • Organizer: 第20回心不全学会学術集会
  • Place of Presentation: ロイトン札幌（札幌）
  • Year and Date: 2016-10-07
• [Presentation] The multidisciplinary approach for young patient with dilated cardiomyopathy (2016)
  • Author(s): Higuchi S, Yamasaki S
  • Organizer: 第20回心不全学会学術集会
  • Place of Presentation: ロイトン札幌（札幌）
  • Year and Date: 2016-10-07
• [Presentation] Association between 6 minutes walking distance and mortality in patients with coronary artery disease and heart failure: a meta-analysis of cohort studies (2016)
  • Author(s): Yamamoto S, Yamasaki S
  • Organizer: European Society of Cardiology
  • Place of Presentation: ローマ（イタリア）
  • Year and Date: 2016-08-27
  • Int'l Joint Research
• [Presentation] 植え込み型補助人工心臓3例の経験から退院の律速因子を検討する (2016)
  • Author(s): 山崎佐枝子
  • Organizer: 第22回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 東京国際フォーラム（東京）
  • Year and Date: 2016-07-16
• [Presentation] 当院の外来心リハの有効性と安全性を検討する (2016)
  • Author(s): 山崎佐枝子
  • Organizer: 第22回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 東京国際フォーラム（東京）
  • Year and Date: 2016-07-16
• [Presentation] 運動時の心拍数から推定された代謝当量は安静時心拍数の影響を受けるのか？ (2016)
  • Author(s): 三澤加代子,山崎佐枝子
  • Organizer: 第22回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 東京国際フォーラム（東京）
  • Year and Date: 2016-07-16
• [Presentation] ベッカー型筋ジストロフィーによる拡張型心筋症に対する植え込み型補助人工心臓術後のリハビリテーション (2016)
  • Author(s): 市村芙美,山崎佐枝子
  • Organizer: 第53回日本リハビリテーション医学会学術集会
  • Place of Presentation: 国立京都国際会館(京都）
  • Year and Date: 2016-06-09
• [Presentation] 心臓リハビリテーションは儲かるのか。当院の収支報告書． (2015)
  • Author(s): 山崎佐枝子、竹内崇博、元木博彦、岡田綾子、柴 祐司、伊澤 淳、宮下裕介、小山 潤、池田宇一、矢嶋史恵、吉沢 恵、三澤加代子、井戸芳和．
  • Organizer: 第21回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 福岡国際会議場（福岡）
  • Year and Date: 2015-07-18
• [Presentation] ファロー四徴症，Rastelli術後の成人先天性心疾患患者に対する外来心臓リハビリテーションの導入． (2015)
  • Author(s): 中曽根沙妃、山崎佐枝子、矢嶋史恵、元木博彦、池田宇一．
  • Organizer: 第21回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 福岡国際会議場（福岡）
  • Year and Date: 2015-07-18
• [Presentation] In-Hospital Prognostic Value of ABI in Patients Underwent Percutaneous Coronary Intervention: A Subanalysis of the Shinano-Registry. (2015)
  • Author(s): Hashizume N, Miura T, Shimada K, Kobayashi M, Nakajima H, Sakai T, Akanuma H, Tomita T, Koyama J, Miyashita Y, Ikeda U.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪）
  • Year and Date: 2015-04-24
• [Presentation] 脂肪幹細胞移植による血管新生療法が有効であった閉塞性動脈硬化症の一例. (2014)
  • Author(s): 木村和広、南澤匡俊、伊澤 淳、宮下裕介、小山 潤、池田宇一.
  • Organizer: 日本心臓病学会学術集会
  • Place of Presentation: 仙台国際センター（仙台）
  • Year and Date: 2014-09-26 – 2014-09-28
• [Presentation] Impact of endovascular therapy on oxidative stress in patients with peripheral artery disease. (2014)
  • Author(s): Ebisawa S, Miyashita Y, Ueki Y, Hioki H, Hashizume N, Abe N, Kashima Y, Miura T, Ikeda U.
  • Organizer: 日本心血管インターベンション治療学会
  • Place of Presentation: 名古屋国際会議場（名古屋）
  • Year and Date: 2014-07-24 – 2014-07-26
• [Presentation] 当院の外来心臓リハビリテーションの実施状況. (2014)
  • Author(s): 山崎佐枝子、矢嶋史恵、三澤加代子、高橋友明、柴 祐司、伊澤 淳、富田 威、宮下裕介、小山 潤、池田宇一．
  • Organizer: 日本心臓リハビリテーション学会学術集会
  • Place of Presentation: みやこめっせ（京都）
  • Year and Date: 2014-07-19 – 2014-07-20