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Impact of exercise therapy on oxidative stress in patients with peripheral artery disease

Research Project

Project/Area Number 26750181
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionShinshu University

Principal Investigator

YAMASAKI Saeko  信州大学, 学術研究院医学系(医学部附属病院), 助教 (50623914)

Research Collaborator EBISAWA Soichiro  信州大学, 医学部附属病院, 講師(特定雇用) (50645439)
KASHIMA Yuichiro  信州大学, 学術研究院医学系(医学部附属病院), 助教 (70545722)
IKEDA Uichi  信州大学, 医学部, 特任教授 (30221063)
KUWAHARA Koichiro  信州大学, 学術研究院医学系, 教授 (30402887)
AONO Minako  信州大学, 医学部附属病院, 技術補佐員
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords循環器、高血圧 / 心臓リハビリテーション / 運動療法 / 福祉 / 閉塞性動脈硬化症 / 循環器内科 / 高血圧 / 循環器・高血圧 / リハビリテーション
Outline of Final Research Achievements

Peripheral artery disease (PAD) is an atherosclerotic disease. PAD patients often have other cardiovascular disease and poor prognosis. Exercise is effective for claudication and prognosis of patients with PAD. Few hospitals give supervised exercise therapy for PAD and report why exercise is effective for PAD. This study enrolled twenty five PAD patients with claudication. The levels of diacron-reactive oxygen metabolite (d-ROM: an oxidative stress marker), ankle-brachial index (ABI), and maximum walking distance at baseline and at 3 months after endovascular therapy (EVT) were measured. As compared with baseline values, the maximum walking distance, ABI and d-ROM improved significantly after EVT (109.9±104.2 vs. 313.7±271.8 m; 0.61±0.15 vs. 0.91±0.13; 472.8±64.8 vs. 390.2 ±46.7 U.CARR).
We encouraged supervised exercise therapy and explained their effect. We succeeded in increasing cardiac rehabilitation.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (19 results)

All 2016 2015 2014

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 5 results) Presentation (13 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] A 2-year follow-up of oxidative stress levels in patients with ST-segment elevation myocardial infarction: a subanalysis of the ALPS-AMI study.2015

    • Author(s)
      Abe N, Kashima Y, Izawa A, Motoki H, Ebisawa S, Miyashita Y, Imamura H, Ikeda U.
    • Journal Title

      Angiology

      Volume: 66(3) Issue: 3 Pages: 271-277

    • DOI

      10.1177/0003319714525656

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between estimated glomerular filtration rate and peripheral arterial disease.2015

    • Author(s)
      Yamasaki S, Izawa A, Koshikawa M, Saigusa T, Ebisawa S, Miura T, Shiba Y, Tomita T, Miyashita Y, Koyama J, Ikeda U.
    • Journal Title

      Journal of Cardiology

      Volume: 66 Issue: 5 Pages: 430-434

    • DOI

      10.1016/j.jjcc.2015.01.011

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic improvement by multidisciplinary therapy in patients with critical limb ischemia.2015

    • Author(s)
      Hioki H, Miyashita Y, Miura T, Ebisawa S, Motoki H, Izawa A, Tomita T, Koyama J, Ikeda U.
    • Journal Title

      Angiology

      Volume: 66(2) Issue: 2 Pages: 187-194

    • DOI

      10.1177/0003319714523113

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Five-year prognosis after endovascular therapy in claudicant patients with iliofemoral artery disease2014

    • Author(s)
      Miura T, Soga Y, Miyashita Y, Iida O, Kawasaki D, Hirano K, Ikeda U.
    • Journal Title

      J Endovasc Ther

      Volume: 21 Issue: 3 Pages: 381-388

    • DOI

      10.1583/13-4618r.1

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of endovascular therapy on oxidative stress in patients with peripheral artery disease.2014

    • Author(s)
      Ebisawa S, Kashima Y, Miyashita Y, Yamazaki S, Abe N, Saigusa T, Miura T, Motoki H, Izawa A, Ikeda U.
    • Journal Title

      Circ J

      Volume: 78(6) Pages: 1445-1450

    • NAID

      130003391109

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diagnostic value of peripheral fractional flow reserve in isolated iliac artery stenosis : A comparison with the post-exercise ankle-brachial index2014

    • Author(s)
      Hioki H, Miyashita Y, Miura T, Ebisawa S, Motoki H, Izawa A, Tomita T, Koyama J, Ikeda U
    • Journal Title

      J Endovasc Ther

      Volume: 21 Issue: 5 Pages: 625-632

    • DOI

      10.1583/14-4734mr.1

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Utility of a Clinical Pathway for Patients Implanted Ventricular Assist Device2016

    • Author(s)
      Yamasaki S
    • Organizer
      第20回心不全学会学術集会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] The multidisciplinary approach for young patient with dilated cardiomyopathy2016

    • Author(s)
      Higuchi S, Yamasaki S
    • Organizer
      第20回心不全学会学術集会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] Association between 6 minutes walking distance and mortality in patients with coronary artery disease and heart failure: a meta-analysis of cohort studies2016

    • Author(s)
      Yamamoto S, Yamasaki S
    • Organizer
      European Society of Cardiology
    • Place of Presentation
      ローマ(イタリア)
    • Year and Date
      2016-08-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 植え込み型補助人工心臓3例の経験から退院の律速因子を検討する2016

    • Author(s)
      山崎佐枝子
    • Organizer
      第22回日本心臓リハビリテーション学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2016-07-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 当院の外来心リハの有効性と安全性を検討する2016

    • Author(s)
      山崎佐枝子
    • Organizer
      第22回日本心臓リハビリテーション学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2016-07-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 運動時の心拍数から推定された代謝当量は安静時心拍数の影響を受けるのか?2016

    • Author(s)
      三澤加代子,山崎佐枝子
    • Organizer
      第22回日本心臓リハビリテーション学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2016-07-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] ベッカー型筋ジストロフィーによる拡張型心筋症に対する植え込み型補助人工心臓術後のリハビリテーション2016

    • Author(s)
      市村芙美,山崎佐枝子
    • Organizer
      第53回日本リハビリテーション医学会学術集会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2016-06-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] 心臓リハビリテーションは儲かるのか。当院の収支報告書.2015

    • Author(s)
      山崎佐枝子、竹内崇博、元木博彦、岡田綾子、柴 祐司、伊澤 淳、宮下裕介、小山 潤、池田宇一、矢嶋史恵、吉沢 恵、三澤加代子、井戸芳和.
    • Organizer
      第21回日本心臓リハビリテーション学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2015-07-18
    • Related Report
      2015 Research-status Report
  • [Presentation] ファロー四徴症,Rastelli術後の成人先天性心疾患患者に対する外来心臓リハビリテーションの導入.2015

    • Author(s)
      中曽根沙妃、山崎佐枝子、矢嶋史恵、元木博彦、池田宇一.
    • Organizer
      第21回日本心臓リハビリテーション学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2015-07-18
    • Related Report
      2015 Research-status Report
  • [Presentation] In-Hospital Prognostic Value of ABI in Patients Underwent Percutaneous Coronary Intervention: A Subanalysis of the Shinano-Registry.2015

    • Author(s)
      Hashizume N, Miura T, Shimada K, Kobayashi M, Nakajima H, Sakai T, Akanuma H, Tomita T, Koyama J, Miyashita Y, Ikeda U.
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report
  • [Presentation] 脂肪幹細胞移植による血管新生療法が有効であった閉塞性動脈硬化症の一例.2014

    • Author(s)
      木村和広、南澤匡俊、伊澤 淳、宮下裕介、小山 潤、池田宇一.
    • Organizer
      日本心臓病学会学術集会
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2014-09-26 – 2014-09-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Impact of endovascular therapy on oxidative stress in patients with peripheral artery disease.2014

    • Author(s)
      Ebisawa S, Miyashita Y, Ueki Y, Hioki H, Hashizume N, Abe N, Kashima Y, Miura T, Ikeda U.
    • Organizer
      日本心血管インターベンション治療学会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Year and Date
      2014-07-24 – 2014-07-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 当院の外来心臓リハビリテーションの実施状況.2014

    • Author(s)
      山崎佐枝子、矢嶋史恵、三澤加代子、高橋友明、柴 祐司、伊澤 淳、富田 威、宮下裕介、小山 潤、池田宇一.
    • Organizer
      日本心臓リハビリテーション学会学術集会
    • Place of Presentation
      みやこめっせ(京都)
    • Year and Date
      2014-07-19 – 2014-07-20
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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