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The effects of rhythmic passive exercise of the lower limbs on the central command activity-Aspiring for the effective exercise therapy

Research Project

Project/Area Number 26750187
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionHiroshima University

Principal Investigator

Liang Nan  広島大学, 医歯薬保健学研究院(保), 助教 (70512515)

Research Collaborator MATSUKAWA KANJI  
TAKAHASHI MAKOTO  
ISHII KEI  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords末梢求心性感覚入力 / 中枢運動指令 / 両側下肢運動 / 呼吸循環応答 / 大脳血流動態 / 末梢筋血流動態 / 運動循環応答 / 中枢神経系 / 同側および対側 / H反射
Outline of Final Research Achievements

The current study aimed to explore the effects of passive movement of the lower limbs on the central nervous system or central command activity. We using healthy humans performed two experiments to clarify that 1) the effects of muscle stretching or vibration on the H-reflex, a common index to assess the spinal excitability,and that 2) the effects of passive ergometer exercise on the cardiorespiratory responses and on the cortical and muscle oxygenation during motor imagery. The results showed that, the muscle vibration in the ipsilateral and contralateral lower limb reduced the spinal excitability. The cardioresipratory responses during motor imagery were enhanced by passive ergometer exercise. However, the oxygenation in the related cerebral cortical areas was reduced, while that in the peripheral agonist muscle was enhanced. These findings suggest that the passive lower limb exercise affects differently the central and peripheral nervous system.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (40 results)

All 2017 2016 2015 2014

All Journal Article (11 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 11 results,  Acknowledgement Compliant: 8 results,  Open Access: 1 results) Presentation (27 results) (of which Int'l Joint Research: 1 results) Book (2 results)

  • [Journal Article] Facial skin blood flow responses to exposures to emotionally charged movies2017

    • Author(s)
      Matsukawa K, Endo K, Ishii K, Ito M, Liang N
    • Journal Title

      Journal of Physiological Sciences

      Volume: 印刷中 Issue: 2 Pages: 1-16

    • DOI

      10.1007/s12576-017-0522-3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Central command generated prior to arbitrary motor execution induces muscle vasodilatation at the beginning of dynamic exercise.2016

    • Author(s)
      Ishii K, Matsukawa K, Liang N, Endo K, Idesako M, Asahara R, Kadowaki A, Wakasugi R, Takahashi M
    • Journal Title

      J Appl Physiol

      Volume: 21 Issue: 12 Pages: 1424-1433

    • DOI

      10.1152/japplphysiol.00103.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The prefrontal oxygenation and ventilatory responses at start of one-legged cycling exercise have relation to central command2016

    • Author(s)
      Asahara R, Matsukawa K, Ishii K, Liang N, Endo K
    • Journal Title

      Journal of Applied Physiology

      Volume: 121 Issue: 5 Pages: 1115-1126

    • DOI

      10.1152/japplphysiol.00401.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Exaggerated sympathetic and cardiovascular responses to stimulation of the mesencephalic locomotor region in spontaneously hypertensive rats2015

    • Author(s)
      Nan Liang, Jere H Mitchell, Scott A Smith, Masaki Mizuno.
    • Journal Title

      American Journal of Physiology Heart and Circulatory Physiology

      Volume: 310 Issue: 1 Pages: 123-131

    • DOI

      10.1152/ajpheart.00479.2015

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Increased oxygenation of the cerebral prefrontal cortex prior to the onset of voluntary exercise in humans2015

    • Author(s)
      Kanji Matsukawa, Kei Ishii, Nan Liang, Kana Endo, Ryo Ohtani, Tomoko Nakamoto, Rie Wakasugi, Akito Kadowaki, Hidehiko Komine.
    • Journal Title

      Journal of Applied Physiology

      Volume: 119 Issue: 5 Pages: 452-462

    • DOI

      10.1152/japplphysiol.00406.2015

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Stimulation of the mesencephalic ventral tegmental area blunts the sensitivity of cardiac baroreflex in decerebrate cats2015

    • Author(s)
      Matsukawa K, Ishii K, Ishida T, Nagai A, Liang N
    • Journal Title

      Auton Neurosci

      Volume: 189 Pages: 16-24

    • DOI

      10.1016/j.autneu.2014.12.005

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Unilateral imagined movement increases interhemispheric inhibition from the contralateral to ipsilateral motor cortex2014

    • Author(s)
      Liang N, Funase K, Takahashi M, Matsukawa K, Kasai T
    • Journal Title

      Exp Brain Res

      Volume: 232 Issue: 6 Pages: 1823-1832

    • DOI

      10.1007/s00221-014-3874-4

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Signal transduction of aortic and carotid sinus baroreceptors is not modified by central command during spontaneous motor activity in decerebrate cats2014

    • Author(s)
      Matsukawa K, Ishii K, Kadowaki A, Ishida T, Idesako M, Liang N
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 306 Issue: 10 Pages: R735-R746

    • DOI

      10.1152/ajpregu.00538.2013

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Discharges of aortic and carotid sinus baroreceptors during spontaneous motor activity- and pharmacologically-evoked pressor interventions2014

    • Author(s)
      Matsukawa K, Ishii K, Kadowaki A, Ishida T, Idesako M, Liang N
    • Journal Title

      J Physiol Sci

      Volume: 64 Issue: 4 Pages: 291-303

    • DOI

      10.1007/s12576-014-0318-7

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Phase dependent modulation of corticospinal excitability during the observation of initial phase of gai2014

    • Author(s)
      Makoto Takahashi, Natsuko Uchida, Mami Yoshida, Nan Liang, Kimitaka Nakazawa, Kiyokazu Sekikawa, Tsutomu Inamizu, Hironobu Hamada
    • Journal Title

      Somatosensory & Motor Research

      Volume: 31 Issue: 4 Pages: 209-213

    • DOI

      10.3109/08990220.2014.923392

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Differential contribution of Ach-muscarinic and β-adrenergic receptors to vasodilatation in noncontracting muscle during voluntary one-legged exercise2014

    • Author(s)
      Ishii K, Matsukawa K, Liang N, Endo K, Idesako M, Hamada H, Kataoka T, Ueno K, Watanabe T, Takahashi M.
    • Journal Title

      Physiol Rep

      Volume: 2 Issue: 11 Pages: e12202-e12202

    • DOI

      10.14814/phy2.12202

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] サイクリング運動の第一人称および第三人称イメージに伴う前頭前野の酸素化動態2017

    • Author(s)
      梁 楠,有川 未紗,佐武 慶彦,遠藤 加菜,浅原 亮太,松川 寛二.
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] 自発的片腕クランキング運動開始前にみられる背外側前頭前野の酸素化2017

    • Author(s)
      石井 圭,松川 寛二,梁 楠.
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] 高齢者における下肢運動イメージに対する筋血流応答2017

    • Author(s)
      遠藤 加菜,石井 圭,浅原 亮太,土井 詩織,梁 楠,松川 寛二.
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] 運動開始前にみられる前頭前野酸素化ヘモグロビン濃度の増加とセントラルコマンド2017

    • Author(s)
      松川 寛二,石井 圭,浅原 亮太,遠藤 加菜,梁 楠.
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] The prefrontal oxygenation at the onset of unrestrained overground walking in humans2016

    • Author(s)
      Ryota Asahara, Kanji Matsukawa, Nan Liang, Kana Endo, Kei Ishii.
    • Organizer
      The 6th International Sports Science Network Forum in Nagano 2016
    • Place of Presentation
      Matsumoto, Japan
    • Year and Date
      2016-11-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 自発運動開始時における前頭前野酸素化ヘモグロビン濃度の増加と換気応答の関連2016

    • Author(s)
      浅原 亮太,松川 寛二,石井 圭,梁 楠,遠藤 加菜.
    • Organizer
      第71回日本体力医学会大会
    • Place of Presentation
      盛岡
    • Year and Date
      2016-09-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] 平地とトレッドミル歩行時の大脳皮質興奮性の変化について-ポータブルfNIRSを用いた解析2016

    • Author(s)
      梁 楠,浅原 亮太,石井 圭,遠藤 加菜,松川 寛二.
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] ヒトの随意運動開始時における前頭前野酸化Hb濃度と呼気終末炭酸ガス濃度の関連2016

    • Author(s)
      浅原 亮太,松川 寛二,石井 圭,梁 楠,遠藤 加菜.
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] 視覚刺激による快・不快の情動変化が顔面皮膚血流量に与える影響2016

    • Author(s)
      遠藤 加菜,伊藤 百花,川原 舞,小畑 菜央,石井 圭,梁 楠,浅原 亮太,松川 寛二.
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] 運動イメージによる呼吸循環系の活性化2016

    • Author(s)
      石井 圭,松川 寛二,梁 楠,遠藤 加菜,浅原 亮太,井出迫 光弘.
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] 視聴覚刺激による快・不快の情動反応が顔面皮膚血流量に及ぼす影響2015

    • Author(s)
      遠藤 加菜,伊藤 百花,石井 圭,梁 楠,松川 寛二.
    • Organizer
      第67回日本生理学会中国四国地方会
    • Place of Presentation
      米子
    • Year and Date
      2015-10-24
    • Related Report
      2015 Research-status Report
  • [Presentation] 除脳ラットを用いた中枢性循環調節機構の探索2015

    • Author(s)
      石井 圭,浅原 亮太,梁 楠,松川 寛二.
    • Organizer
      第67回日本生理学会中国四国地方会
    • Place of Presentation
      米子
    • Year and Date
      2015-10-24
    • Related Report
      2015 Research-status Report
  • [Presentation] 無拘束状態での床歩行時とトレッドミル歩行時にみられる大脳皮質運動野活動2015

    • Author(s)
      浅原 亮太,石井 圭,遠藤 加菜,梁 楠,松川 寛二.
    • Organizer
      第67回日本生理学会中国四国地方会
    • Place of Presentation
      米子
    • Year and Date
      2015-10-24
    • Related Report
      2015 Research-status Report
  • [Presentation] 手指筋力発揮速度の違いは同側運動野の興奮性に異なる影響を及ぼす2015

    • Author(s)
      梁 楠,有澤 利顕,橘高 照人,高橋 真,石井 圭,遠藤 加菜,松川 寛二.
    • Organizer
      第70回日本体力医学会大会
    • Place of Presentation
      和歌山
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 随意運動に先行する前頭前野の酸素化ヘモグロビン濃度増加:Central commandとの関連2015

    • Author(s)
      松川 寛二,石井 圭,梁 楠,遠藤 加菜,小峰 秀彦.
    • Organizer
      第70回日本体力医学会大会
    • Place of Presentation
      和歌山
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Facial skin blood flow response during exposure to emotionally-charged movie2015

    • Author(s)
      Ishii K, Ito M, Endo K, Liang N, Idesako M, Matsukawa K.
    • Organizer
      Experimental Biology 2015
    • Place of Presentation
      Boston, USA
    • Year and Date
      2015-03-28 – 2015-04-01
    • Related Report
      2014 Research-status Report
  • [Presentation] 麻酔下ラットにおける島皮質の電気刺激は中脳腹側被蓋野の局所血流量を増加させる2015

    • Author(s)
      梁 楠,松川 寛二,石井 圭,井手迫 光弘,遠藤 加菜.
    • Organizer
      第120回日本解剖学会総会・全国学術集会/第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 動脈血圧反射の心拍数調節感度はトレッドミル運動の強度と継続時間に依存して低下する2015

    • Author(s)
      井手迫 光弘,松川 寛二,石井 圭,梁 楠,遠藤 加菜.
    • Organizer
      第120回日本解剖学会総会・全国学術集会/第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] ストループ課題における前頭前野の酸素動態に加齢が与える影響2015

    • Author(s)
      遠藤 加菜,梁 楠,石井 圭,井手迫 光弘,松川 寛二.
    • Organizer
      第120回日本解剖学会総会・全国学術集会/第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] ヒト片腕運動時にみられる骨格筋コリンおよびβアドレナリン作動性血管拡張2015

    • Author(s)
      石井 圭,松川 寛二,梁 楠,遠藤 加菜,井手迫 光弘,濱田 泰伸,片岡 健,山下 かおり,渡邊 多恵.
    • Organizer
      第120回日本解剖学会総会・全国学術集会/第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 随意運動時にみられる非活動筋血流量の増加と神経調節メカニズム2015

    • Author(s)
      松川 寛二,石井 圭,梁 楠,遠藤 加菜.
    • Organizer
      第120回日本解剖学会総会・全国学術集会/第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] The sensitivity of cardiac baroreflex is decreased at the onset of and during the later period of treadmill exercise at a higher intensity in conscious cats2015

    • Author(s)
      Kanji Matsukawa, Kei Ishii, Mitsuhiro Idesako, Nan Liang, Kana Endo.
    • Organizer
      International Symposium on Human Adaptation to Environment and Whole-body Coordination
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2015-03-14 – 2015-03-16
    • Related Report
      2014 Research-status Report
  • [Presentation] 大動脈弓血圧受容器反射による心拍数調節ゲインはトレッドミル運動の強度に依存して低下する2014

    • Author(s)
      井手迫 光弘,松川 寛二,石井 圭,梁 楠,遠藤 加菜.
    • Organizer
      第66回日本生理学会・中国四国地方会
    • Place of Presentation
      香川
    • Year and Date
      2014-11-01 – 2014-11-02
    • Related Report
      2014 Research-status Report
  • [Presentation] 心拍数・動脈血圧よりも筋組織血流量の変化は運動イメージの抽出に有効である2014

    • Author(s)
      松川 寛二,石井 圭,遠藤 加菜,梁 楠,井手迫 光弘,土井 詩織,崎田 有紀
    • Organizer
      第69回日本体力医学会大会
    • Place of Presentation
      長崎
    • Year and Date
      2014-09-19 – 2014-09-21
    • Related Report
      2014 Research-status Report
  • [Presentation] セントラルコマンドはaortic baroreceptor-heart rate反射を孤束核内で抑制する2014

    • Author(s)
      石井 圭,松川 寛二,井手迫 光弘,梁 楠
    • Organizer
      運動と循環研究会
    • Place of Presentation
      倉敷
    • Year and Date
      2014-07-18
    • Related Report
      2014 Research-status Report
  • [Presentation] Inhibition of soleus H-reflex by afferent inputs from the contralateral homonymous muscle2014

    • Author(s)
      Nan Liang, Aiko Takezawa, Ayumi Tsubota, Makoto Takahashi, Kanji Matsukawa.
    • Organizer
      The 16th International Congress of the World Federation of Occupational Therapists (in collaboration with the 48th Japanese Occupational Therapy Congress and Expo)
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2014-06-18 – 2014-06-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Effect of acute dynamic exercise on cognitive function in elderly subjects2014

    • Author(s)
      Kana Endo, Nan Liang, Kei Ishii, Mitsuhiro Idesako, Kanji Matsukawa.
    • Organizer
      The 16th International Congress of the World Federation of Occupational Therapists (in collaboration with the 48th Japanese Occupational Therapy Congress and Expo)
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2014-06-18 – 2014-06-21
    • Related Report
      2014 Research-status Report
  • [Book] 脳卒中のリハビリテーション、生活機能に基づくアプローチ(第3版)、第1章:脳卒中患者の病態生理、医学的管理と急性期リハビリテーション2015

    • Author(s)
      梁 楠 (分担翻訳)
    • Total Pages
      54
    • Publisher
      三輪書店
    • Related Report
      2015 Research-status Report
  • [Book] 脳卒中のリハビリテーション、生活機能に基づくアプローチ(第3版)、第2章:脳卒中リハビリテーションの心理的側面2015

    • Author(s)
      梁 楠 (分担翻訳)
    • Total Pages
      18
    • Publisher
      三輪書店
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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