| Project/Area Number |
26750189
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Nagasaki University |
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Principal Investigator |
SASABE Ryo 長崎大学, 病院(医学系), 技術職員 (50710985)
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| Co-Investigator(Renkei-kenkyūsha) |
OKITA Minoru 長崎大学, 医歯薬学総合研究科(医学系), 教授 (50244091)
NAKANO Jiro 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (20380834)
SAKAMOTO Junya 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (20584080)
HONDA Yuichiro 長崎大学, 病院(医学系), 技術職員 (40736344)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 不動 / 線維化 / 関節包 / 筋線維芽細胞 / コラーゲン / 振動刺激 / type I collagen / type III collagen |
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| Outline of Final Research Achievements |
The purpose of this study was to examine the time-dependent changes in the development of joint capsule fibrosis and in the number of myofibroblasts in the joint capsule after immobilization and effects of vibration on jonit contracture, using a rat knee contracture model.
This study revealed that joint capsule fibrosis with overexpression of type I collagen occurs and progresses within 1 week after immobilization, and an increase in myofibroblasts is related to the mechanism of joint capsule fibrosis. However, it was indicated that the immobilization-induced joint contracture might not be inhibited by vibration stimulator.
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