• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Effects of different mechanical stress on discipline and metabolic of articular chondrocytes in rat

Research Project

Project/Area Number 26750204
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionNiigata University of Health and Welfare

Principal Investigator

Takahashi Hideaki  新潟医療福祉大学, 医療技術学部, 助教 (90636250)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsメカニカルストレス / 不動 / 関節軟骨
Outline of Final Research Achievements

Degeneration of Articular cartilage induced such as osteoarthritis and immobilization. Typically, chondrocytes forms a discipline array as a column shape from joint surface. However, non-physiological mechanical stress (overloading or stress deprivation) is observed not only joint degeneration, but also loss of the number of chondrocyte. In the present study, we conducted a quantitative analysis of the chondrocyte array in Osteoarthritis (OA) model rat and immobilization model rat. As a result, the loss of chondrocyte array was confirmed in part of OA. Hence, it was inferred that chondrocyte discipline is also important factor to maintain homeostasis of articular cartilage.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2014

All Presentation (1 results)

  • [Presentation] ラット坐骨神経切除後の脛骨関節軟骨における細胞配列規則性の変化2014

    • Author(s)
      高橋英明
    • Organizer
      第1回日本基礎理学療法学会学術集会  日本基礎理学療法学会 第4回学術大会 合同開催
    • Place of Presentation
      名古屋学院大学
    • Year and Date
      2014-11-15 – 2014-11-16
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi