Effects of different mechanical stress on discipline and metabolic of articular chondrocytes in rat
| Project/Area Number |
26750204
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Niigata University of Health and Welfare |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | メカニカルストレス / 不動 / 関節軟骨 |
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| Outline of Final Research Achievements |
Degeneration of Articular cartilage induced such as osteoarthritis and immobilization. Typically, chondrocytes forms a discipline array as a column shape from joint surface. However, non-physiological mechanical stress (overloading or stress deprivation) is observed not only joint degeneration, but also loss of the number of chondrocyte. In the present study, we conducted a quantitative analysis of the chondrocyte array in Osteoarthritis (OA) model rat and immobilization model rat. As a result, the loss of chondrocyte array was confirmed in part of OA. Hence, it was inferred that chondrocyte discipline is also important factor to maintain homeostasis of articular cartilage.
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Report
(3 results)
Research Products
(1 results)
