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Influence of ultrasound on cross-talk between satellite cells, muscle fiber and macrophages

Research Project

Project/Area Number 26750205
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionTokoha University

Principal Investigator

AGATA Nobuhide  常葉大学, 保健医療学部, 講師 (00549313)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords筋損傷 / 筋衛星細胞 / 超音波 / リハビリテーション / マクロファージ
Outline of Final Research Achievements

It is becoming clear that ultrasound stimulation promotes recovery from muscle damage. However, to design a therapeutic strategy for promoting recovery from muscle damage, it is necessary to clarify the effect of promoting recovery from muscle damage by ultrasound stimulation nad its mechanism. Therefore, the purpose of this study was to clarify how Cross-Talk between each cell is involved in promoting recovery from muscle damage by ultrasound stimulation. The result of this study revealed that ultrasound stimulation promotes muscle satellite cell proliferation using mouse cultured muscle satellite cells. It was also revealed that proliferation of muscle satellite cells promoted dependently on stimulation intensity.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2017 2016 2015 2014

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (4 results)

  • [Journal Article] Training at non-damaging intensities facilitates recovery from muscle atrophy.2017

    • Author(s)
      Itoh Y, Murakami T, Mori T, Agata N, Kimura N, Inoue-Miyazu M, Hayakawa K, Hirano T, Sokabe M, Kawakami K
    • Journal Title

      Muscle and Nerve

      Volume: 55(2) Issue: 2 Pages: 243-253

    • DOI

      10.1002/mus.25218

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Stretch speed-dependent myofibre damage and functional deficits in rat skeletal muscle induced by lengthening contraction2014

    • Author(s)
      Mori T., Agata N., Itoh Y., Inoue-Miyazu M., Sokabe M., Taguchi T., Kawakami K.
    • Journal Title

      Physiological Reports

      Volume: 2 Issue: 11 Pages: 1-10

    • DOI

      10.14814/phy2.12213

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 超音波刺激によって筋衛星細胞の増殖は促進される2016

    • Author(s)
      縣 信秀,宮津真寿美,河上敬介
    • Organizer
      第51回日本理学療法学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-05-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] 光増感(PIT)法による中大脳動脈血栓モデルラットにおける運動機能回復と神経新生2016

    • Author(s)
      縣信秀,外村和也,森下紗帆,熊田竜郎,梅村和夫,筒井祥博
    • Organizer
      第121回日本解剖学会全国学術集会
    • Place of Presentation
      郡山
    • Year and Date
      2016-03-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 筋損傷からの回復を促進させる超音波刺激はMyoD, myogenin 量を亢進させる2015

    • Author(s)
      柴田篤志,森友洋,縣信秀,宮本靖義,宮津真寿美,河上敬介
    • Organizer
      第50回日本理学療法学術大会
    • Place of Presentation
      東京
    • Year and Date
      2015-06-06
    • Related Report
      2015 Research-status Report
  • [Presentation] 筋損傷後早期の超音波刺激は筋衛星細胞の活性と損傷からの回復を促進させる2014

    • Author(s)
      柴田篤志、森友洋、縣信秀、宮本靖義、宮津真寿美、河上敬介
    • Organizer
      第1回日本基礎理学療法学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-11-15
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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