| Project/Area Number |
26750211
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Research Collaborator |
KOMORI Tetsuo
ABE Tatsuya
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | F波 / 反復F波 / ポリオ後症候群 / 運動ニューロン疾患 / 前角細胞障害 / 波形解析 / 末梢神経障害 / 前角細胞機能 / 神経筋超音波 |
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| Outline of Final Research Achievements |
The purpose of this study was to determine whether F-waves reveal electrophysiological features of anterior horn cells in polio survivors.
Forty-three polio survivors and 20 healthy controls underwent motor nerve conduction studies of the median and tibial nerves bilaterally, including F-waves and the determination of motor unit number estimate(MUNE). A significant increase in repeater F-waves and a reduction of F-wave persistence were observed in both nerves in the polio group as compared with the control group. Repeater F-waves had a negative correlation with MUNE. Furthermore, as polio severity worsened, repeater F-waves increased, followed by a reduction in F-wave persistence. These findings suggest that repeater F-waves are an early sign of motor unit pathology in polio survivors.
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