Effects of hyperthermic therapy intervention for oxaliplatin-induced peripheral neuropathy in colorectal cancer patients undergoing adjuvant chemotherapy

• Project/Area Number: 26750225
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: National Cancer Center Japan (2016); Sapporo Medical University (2014-2015)
• Principal Investigator: Hikaru Ihira 国立研究開発法人国立がん研究センター, 社会と健康研究センター, 特任研究員 (60516590)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: がんリハビリテーション / 外来化学療法 / 理学療法 / 物理療法 / 化学療法

Outline of Final Research Achievements

The oxaliplatin-induced peripheral neuropathy (OIPN) is manifested with the neuromyotonia-like acute transient syndrome, these symptoms have influence on the activities daily living or the quality of life in patients received outpatient chemotherapy. The purpose of this study was to examine the effect of hyperthermic therapy for OIPN in outpatient chemotherapy. Thirty four patients (22 men, 12 women, age; 63.5±11.7 years) were assessed peripheral neuropathy of hands at baseline and carried out hyperthermic therapy. Hyperthermic therapy included the wearing of thermal glove and avoidance of cold exposure in daily living. As a result from this study, although hand grip were likely to protect the functional decline, no statistically significant effect was observed in assessment items.

Research Products

• [Presentation] Hyperthermic therapy for oxaliplatin-induced peripheral neuropathy in outpatient chemotherapy center (2015)
  • Author(s): Ihira H, Takimoto R, Matsuda Y, Sato Y, Ono M, Sato M, Osuga T, Arihara Y, Ishiai S, Kato J, Furuna T
  • Organizer: 53rd Annual Meeting of Japan Society of Clinical Oncology
  • Place of Presentation: 国立京都国際会館（京都市左京区）
  • Year and Date: 2015-10-30
• [Presentation] 温熱介入によってオキサリプラチン誘発性末梢神経障害の発症抑制と改善を経験した2症例 (2015)
  • Author(s): 井平光、瀧本理修、松田夕香、牧野圭太郎、小野道洋、岡川泰、石合純夫、加藤淳二、古名丈人
  • Organizer: 第13回日本臨床腫瘍学会学術集会
  • Place of Presentation: 札幌市教育文化会館（札幌市中央区）
  • Year and Date: 2015-07-18
• [Presentation] 温熱介入によってオキサリプラチン誘発性末梢神経障害の発症抑制と改善を経験した2症例 (2015)
  • Author(s): 井平光
  • Organizer: 日本臨床腫瘍学会
  • Place of Presentation: 札幌
  • Year and Date: 2015-07-16 – 2015-07-18