Exercise-induced mitochondrial biogenesis and DNA methylation
| Project/Area Number |
26750304
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Sports science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KITAOKA Yu 東京大学, 総合文化研究科, 助教 (30726914)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 運動 / 骨格筋 / ミトコンドリア |
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| Outline of Final Research Achievements |
It is well known that exercise induces mitochondrial biogenesis in skeletal muscle. The aim of our study was to examine the effect of exercise on DNA methylation. DNMT1 (DNA methyltransferase 1) protein content was not altered after exercise training, but significantly decreased after denervation in skeletal muscle. Our observations suggest that inactivity-induced muscle dysfunction may be induced by increased DNA methylation levels.
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Report
(3 results)
Research Products
(8 results)
