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Response and adaptation of skeletal muscle to endurance training based on circadian rhythms of clock gene expression.

Research Project

Project/Area Number 26750312
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Sports science
Research InstitutionDoshisha University

Principal Investigator

Takakura Hisashi  同志社大学, スポーツ健康科学部, 助教 (20631914)

Co-Investigator(Renkei-kenkyūsha) IZAWA Tetsuya  同志社大学, スポーツ健康科学部, 教授 (70147495)
MASUDA Shinya  京都医療センター臨床研究センター, 糖尿病研究部, 研究員 (80638403)
HIEDA Mutsuko  豊橋技術科学大学, 総合教育院, 准教授 (70707455)
KATOU Hisashi  同志社大学, スポーツ健康科学部, 教授 (30780275)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords時計遺伝子 / 骨格筋 / 転写因子 / ミトコンドリア生合成 / 持久的トレーニング / ミトコンドリア / 細胞内酸素代謝
Outline of Final Research Achievements

The purpose of this study was to determine whether exercise timing enhanced exercise training (TR)-induced increase in the levels of mitochondrial proteins in skeletal muscles. The treadmill TR for 9 weeks was conducted at two time points (TR@zeitgeber time 0 (ZT0) and TR@ZT10). Both of per2 and pgc-1α mRNA expression showed the highest level at ZT0 and lowest level at ZT10. Additionally, the rats underwent acute exercise at the same time points (Ex@ZT0 and Ex@ZT10). The TR significantly increased levels of the mitochondrial protein (COXIV) in the deep portion of gastrocnemius muscle. Moreover, COXIV level in the TR@ZT10 group increased significantly compared to those in the TR@ZT0 group. Indeed, pgc-1α mRNA expression increased significantly immediately after acute exercise only at Ex@ZT10. The timing of TR influenced TR-induced adaptation. This differential adaptation might be caused by the differential PGC-1α expression upon acute exercise.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (11 results)

All 2016 2015

All Presentation (11 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Presentation] EXERCISE TRAINING ALTERS EXPRESSION OF DEVELOPMENTAL GENES AND ADIPOGENIC POTENTIAL IN ADIPOCYTES AND ADIPOSE-DELIVERED STEM CELLS ISOLATED FROM SUBCUTANEOUS AND VISCERAL FAT DEPOTS.2016

    • Author(s)
      Kato H, Takakura H, Hieda M, Ohira Y and Izawa T
    • Organizer
      The Integrative Biology of Exercise VII
    • Place of Presentation
      Phoenix, Arizona, USA
    • Year and Date
      2016-11-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] RESPONSE AND ADAPTATION OF SKELETAL MUSCLE TO ENDURANCE TRAINING BASED ON CIRCADIAN RHYTHMS OF CLOCK GENE EXPRESSION.2016

    • Author(s)
      Takakura H, Kato H, Masuda S, Ueno D, Hieda M and Izawa T
    • Organizer
      The Integrative Biology of Exercise VII
    • Place of Presentation
      Phoenix, Arizona, USA
    • Year and Date
      2016-11-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] eNOSの日内変動と運動トレーニングの影響について.2016

    • Author(s)
      稗田睦子, 高倉久志, 加藤久詞, 井澤鉄也
    • Organizer
      第71回日本体力医学会
    • Place of Presentation
      岩手県民情報交流センター/盛岡地域交流センター市民文化ホール
    • Year and Date
      2016-09-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] 時計遺伝子発現リズムに基づいた一過性運動が骨格筋の応答に及ぼす影響について.2016

    • Author(s)
      高倉久志, 上野大心, 加藤久詞, 増田慎也, 稗田睦子, 井澤鉄也
    • Organizer
      第71回日本体力医学会
    • Place of Presentation
      岩手県民情報交流センター/盛岡地域交流センター市民文化ホール
    • Year and Date
      2016-09-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] 皮下脂肪組織・内臓脂肪組織の発生遺伝子に及ぼす運動トレーニングの影響.2016

    • Author(s)
      加藤久詞, Minas Nalbandian, 高倉久志, 稗田睦子, 井澤鉄也
    • Organizer
      第71回日本体力医学会
    • Place of Presentation
      岩手県民情報交流センター/盛岡地域交流センター市民文化ホール
    • Year and Date
      2016-09-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] 時計遺伝子BMAL1の発現リズムに基づいた運動トレーニングは脂肪分解反応に違いをもたらす.2016

    • Author(s)
      加藤久詞, 高倉久志, 井澤鉄也
    • Organizer
      第24回日本運動生理学会大会
    • Place of Presentation
      熊本大学 黒髪キャンパス
    • Year and Date
      2016-07-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] 時計遺伝子発現リズムに基づいた運動トレーニングがミトコンドリア生合成に及ぼす影響について.2016

    • Author(s)
      高倉久志, 加藤久詞, 増田慎也, 上野大心, 和田理恵子, 柘植厚志, 奥野雄也, 浦崎僚大, 井澤鉄也
    • Organizer
      京都滋賀体育学会第145回大会
    • Place of Presentation
      同志社大学(京都府)
    • Year and Date
      2016-03-13
    • Related Report
      2015 Research-status Report
  • [Presentation] 時計遺伝子発現リズムに基づいた持久的運動トレーニングが骨格筋の有酸素性代謝能力に及ぼす影響について.2016

    • Author(s)
      高倉久志, 加藤久詞, 井澤鉄也
    • Organizer
      日本体力医学会第30回近畿地方会
    • Place of Presentation
      大阪市立大学(大阪府)
    • Year and Date
      2016-02-20
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 時計遺伝子発現リズムに基づいた運動実施タイミングの違いが骨格筋の応答および適応に及ぼす影響について.2016

    • Author(s)
      高倉久志
    • Organizer
      第8回分子骨格筋代謝研究会
    • Place of Presentation
      京都大学吉田南キャンパス
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 時計遺伝子発現リズムに基づいた持久的運動トレーニングが骨格筋適応に及ぼす影響について.2015

    • Author(s)
      高倉久志, 加藤久詞, 増田慎也, 上野大心, 井澤鉄也
    • Organizer
      第70回日本体力医学会
    • Place of Presentation
      和歌山県民文化会館、ホテルアバローム紀の国(和歌山県)
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] EFFECT OF THE TIMING OF EXERCISE ON ENDURANCE TRAINING-INDUCED ADAPTATION IN SKELETAL MUSCLES.2015

    • Author(s)
      Takakura H, Kato H, Masuda S, Ueno D and Izawa T
    • Organizer
      The 15th International Biochemistry of Exercise Conference
    • Place of Presentation
      Reboucas Convention Center (SaoPaulo, Brazil)
    • Year and Date
      2015-09-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2014-04-04   Modified: 2018-03-22  

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