Response and adaptation of skeletal muscle to endurance training based on circadian rhythms of clock gene expression.
| Project/Area Number |
26750312
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Sports science
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| Research Institution | Doshisha University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
IZAWA Tetsuya 同志社大学, スポーツ健康科学部, 教授 (70147495)
MASUDA Shinya 京都医療センター臨床研究センター, 糖尿病研究部, 研究員 (80638403)
HIEDA Mutsuko 豊橋技術科学大学, 総合教育院, 准教授 (70707455)
KATOU Hisashi 同志社大学, スポーツ健康科学部, 教授 (30780275)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 時計遺伝子 / 骨格筋 / 転写因子 / ミトコンドリア生合成 / 持久的トレーニング / ミトコンドリア / 細胞内酸素代謝 |
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| Outline of Final Research Achievements |
The purpose of this study was to determine whether exercise timing enhanced exercise training (TR)-induced increase in the levels of mitochondrial proteins in skeletal muscles. The treadmill TR for 9 weeks was conducted at two time points (TR@zeitgeber time 0 (ZT0) and TR@ZT10). Both of per2 and pgc-1α mRNA expression showed the highest level at ZT0 and lowest level at ZT10. Additionally, the rats underwent acute exercise at the same time points (Ex@ZT0 and Ex@ZT10). The TR significantly increased levels of the mitochondrial protein (COXIV) in the deep portion of gastrocnemius muscle. Moreover, COXIV level in the TR@ZT10 group increased significantly compared to those in the TR@ZT0 group. Indeed, pgc-1α mRNA expression increased significantly immediately after acute exercise only at Ex@ZT10. The timing of TR influenced TR-induced adaptation. This differential adaptation might be caused by the differential PGC-1α expression upon acute exercise.
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Report
(4 results)
Research Products
(11 results)
