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Quantitative analysis of glucose and lipid metabolism in skeletal muscle during heavy exercise using the 13C-glucose breath test

Research Project

Project/Area Number 26750316
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Sports science
Research InstitutionMorinomiya University of Medical Sciences

Principal Investigator

Ueda Shinya  森ノ宮医療大学, 保健医療学部, 講師 (40616926)

Research Collaborator MIYAMOTO TADAYOSHI  森ノ宮医療大学, 保健医療学部, 教授 (40294136)
NAKAHARA HIDEHIRO  森ノ宮医療大学, 保健医療学部, 准教授 (90514000)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords糖代謝 / 激運動 / 13C安定同位体 / 糖質代謝 / サッカー選手 / 高強度運動 / 安定同位体比分析 / システム動態解析 / 糖脂質代謝 / グルコース / 乳酸 / カテコラミン / 安定同位体
Outline of Final Research Achievements

The quantification of glucose metabolism may provide a deeper understanding of the potential of energy metabolism in athletes. The purpose of this study was to investigate the effects of heavy exercise on glucose metabolism in skeletal muscle in severe-intensity interval athletes using the 13C-glucose breath test. The following results were obtained: 1) Resting glucose metabolism was significantly higher in athletes than in normal subjects. 2) Resting glucose metabolism was significantly lower post detraining than pre detraining. 3) Glucose metabolism during heavy exercise was significantly lower in college soccer players than college athletes other than severe-intensity interval athletes. The mechanism underlying this phenomenon is not yet fully understood; however, clear understanding of this mechanism may help us to develop new exercise training programs for the performance improvement in severe-intensity interval athletes.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (9 results)

All 2016 2015 2014

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (4 results)

  • [Journal Article] Electroacupuncture most effectively elicits depressor and bradycardic responses at 1 Hz in humans2016

    • Author(s)
      Nakahara H, Kawada T, Ueda SY, Kawai E, Yamamoto H, Sugimachi M, Miyamoto T.
    • Journal Title

      Clin Auton Res

      Volume: 26 Issue: 1 Pages: 59-66

    • DOI

      10.1007/s10286-015-0330-x

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Periodic Breathing in Heart Failure Explained by Dynamic and Static Properties of Respiratory Control.2015

    • Author(s)
      Miyamoto T, Nakahara H, Ueda S, Manabe K, Kawai E, Inagaki M, Kawada T, Sugimachi M.
    • Journal Title

      Clin Med Insights Cardiol.

      Volume: 29 Pages: 133-42

    • DOI

      10.4137/cmc.s18761

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neural regulation of hindlimb muscle contraction-induced glucagon-like peptide-1 and peptide YY secretion in rats2015

    • Author(s)
      Ueda S, Nakahara H, Manabe K, Miyamoto T.
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 4 Issue: 1 Pages: 125-131

    • DOI

      10.7600/jpfsm.4.125

    • NAID

      130005130588

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Low-Frequency Severe-Intensity Interval Training Improves Cardiorespiratory Functions.2015

    • Author(s)
      Nakahara H, Ueda SY, Miyamoto T.
    • Journal Title

      Med Sci Sports Exerc.

      Volume: 47 Issue: 4 Pages: 789-98

    • DOI

      10.1249/mss.0000000000000477

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Manipulation of central blood volume and implications for respiratory control function.2014

    • Author(s)
      Miyamoto T, Bailey DM, Nakahara H, Ueda S, Inagaki M, Ogoh S.
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: 306 Issue: 12 Pages: 1669-1678

    • DOI

      10.1152/ajpheart.00987.2013

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 4週間の脱トレーニングは糖代謝能を低下させる~13C-グルコースによる糖代謝測定を用いた検討~2016

    • Author(s)
      上田真也, 中原英博, 河合英理子, 東浦瑠依, 宮本忠吉
    • Organizer
      第71回日本体力医学会大会
    • Place of Presentation
      いわて県民情報交流センター(岩手県)
    • Year and Date
      2016-09-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] アスリートにおける肝糖代謝能の非侵襲的評価法の開発2015

    • Author(s)
      上田真也,中原英博,河合英理子,宮本忠吉
    • Organizer
      第70回日本体力医学会
    • Place of Presentation
      和歌山県民文化会館
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 水中歩行は消化管ホルモンを介して摂食抑制効果をもたらす2014

    • Author(s)
      上田真也, 中原英博,眞鍋幸,河合英理子,臼井達矢,織田恵輔,宮本忠吉.
    • Organizer
      第69回日本体力医学会大会
    • Place of Presentation
      長崎大学(長崎県)
    • Year and Date
      2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 水中歩行が消化管ホルモンおよび食事量に及ぼす影響 ~陸上歩行との比較~2014

    • Author(s)
      上田真也, 中原英博, 臼井達矢,織田恵輔,宮本忠吉.
    • Organizer
      第22回日本運動生理学会大会
    • Place of Presentation
      川崎医療福祉大学(岡山県)
    • Year and Date
      2014-07-19
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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