Establishment of Effective Nutrition Guidance Based on the Nutrients and Adipocytokines to Prevent Cardiovascular Diseases

• Project/Area Number: 26750330
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: Department of Clinical Research, National Hospital Organization Kyoto Medical Center
• Principal Investigator: SASAKI YOUSUKE 独立行政法人国立病院機構(京都医療センター臨床研究センター), 糖尿病研究部, 研究員 (00533837)
• Co-Investigator(Renkei-kenkyūsha): ASAHARA Noriko (SATOH Noriko) 京都医療センター・臨床研究センター, 糖尿病研究部, 研究室長 (80373512)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 栄養指導 / 肥満症 / 糖尿病 / 代謝症候群 / アディポサイトカイン / 動脈硬化症 / 心血管病 / 腸内細菌叢 / イソフラボン / エクオール

Outline of Final Research Achievements

We constructed a multicenter prospective cohort of patients with obesity and diabetes and found (1) exacerbation of inflammatory properties of monocytes/carotid plaque by diabetes, (2) relationship of the adipose tissue-derived product, TSP-1, with the visceral fat obesity-related diseases, (3) positive association of the intake rate of soy products with the adiponectin level, (4) positive association of the serum ratio of eicosapentaenoic acid (EPA) to arachidonic acid with the adiponectin level, and (5) anti-inflammatory effects of EPA on cerebral macrophages. We also showed the reduction of LDL-C and CAVI, an indicator of atherosclerosis, by administration of soy bean-metabolites of enterobacteria, and the LDL-C reduction was positively correlated with the CAVI reduction. Our findings should contribute to the establishment of effective nutrition guidance to reduce risk for cardiovascular diseases by focusing on the lipid quality and intestinal flora.

Research Products

• [Journal Article] Hyperglycemia and Inflammatory Proerty of Circulating Monocytes are Associated with Inflammatory Property of Carotid Plaques in Patients Undergoing Carotid Endarterectomy. (2016)
  • Author(s): Tanaka M, Masuda S, Matsuo Y, Sasaki Y, Yamakage H, Muranaka K, Wada H, Hasegawa K, Tsukahara T, Shimatsu A, Satoh-Asahara N
  • Journal Title: J Atheroscler Thromb Volume: 23
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Thrombospondin 1 as a novel biological marker of obesity and metabolic syndrome (2015)
  • Author(s): Matsuo Y, Tanaka M, Yamakage H, Sasaki Y, Muranaka K, Hata H, Ikai I, Shimatsu A, Inoue M, Chun TH, Satoh-Asahara N
  • Journal Title: Metabolism Volume: 64 Issue: 11 Pages: 1490-1499
  • DOI: 10.1016/j.metabol.2015.07.016
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 内臓・皮下脂肪蓄積における線維化関連因子TSP-1の病態生理学的意義の検討 (2015)
  • Author(s): 浅原哲子、松尾禎之、田中将志、増田慎也、佐々木洋介、山陰一、村中和哉、猪飼伊和夫、畑啓昭、井上真由美、全泰和、島津章
  • Organizer: 第33回内分泌代謝学サマーセミナー
  • Place of Presentation: 福岡
  • Year and Date: 2015-07-09
• [Presentation] 肥満における内臓・皮下脂肪蓄積と線維化関連因子TSP-1との関連解析 (2015)
  • Author(s): 松尾禎之、田中将志、佐々木洋介、山陰一、村中和哉、猪飼伊和夫、畑啓昭、島津章、井上真由美、全泰和、浅原哲子
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: 山口
  • Year and Date: 2015-05-21
• [Presentation] 肥満における内臓・皮下脂肪蓄積と線維化関連因子TSP-1との関連解析 (2015)
  • Author(s): 松尾禎之、田中将志、佐々木洋介、山陰一、村中和哉、猪飼伊和夫、畑啓昭、島津章、井上真由美、全泰和、浅原哲子
  • Organizer: 第88回日本内分泌学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2015-04-23
• [Presentation] 糖尿病・肥満における頸動脈プラーク浸潤マクロファージと末梢血単球のM1/M2形質の連関 (2015)
  • Author(s): 田中将志、松尾禎之、佐々木洋介、山陰一、村中和哉、塚原徹也、島津章、浅原哲子
  • Organizer: 第88回日本内分泌学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2015-04-23
• [Presentation] Sexually dimorphic, fat depot-dependent expression of a fibrogenic adipokine, thrombospondin 1 (THBS1) in human obesity. (2015)
  • Author(s): Satoh-Asahara N, Matsuo Y, Tanaka M, Sasaki Y, Yamakage H, Muranaka K, Ikai I, Hata H, Shimatsu A, Inoue M, Tae-Hwa Chun.
  • Organizer: 2015 Keystone Symposia Conference
  • Place of Presentation: Kanada, British Columbia,Wistler
  • Year and Date: 2015-03-22 – 2015-03-27
• [Presentation] GLP-1 receptor agonist attenuates the oxidized-LDL-induced form cell formation through autophagy in macrophages and monocytes. (2015)
  • Author(s): Tanaka M, Matsuo Y, Muranaka K, Yamakage H, Sasaki Y, Shimatsu A, Satoh-Asahara N.
  • Organizer: 2015 Keystone Symposia Conference
  • Place of Presentation: Kanada, British Columbia,Wistler
  • Year and Date: 2015-03-22 – 2015-03-27
• [Presentation] 糖尿病における心腎連関進展予測指標としてのnon HDL-C・参加LDLの有用性 (2014)
  • Author(s): 伊藤遼、山陰一、佐々木洋介、村中和哉、小島真司、河野茂夫、島津章、浅原哲子
  • Organizer: 第５０回日本糖尿病協会近畿地方会
  • Place of Presentation: 京都
  • Year and Date: 2014-11-23
• [Presentation] DPP-4阻害薬による未梢血単球M1/M2タイプへの影響と抗動脈硬化作用 (2014)
  • Author(s): 浅原哲子、佐々木洋介、山陰一、村中和哉、伊藤遼、小島真司、河野茂夫、島津章
  • Organizer: 第５０回日本糖尿病協会近畿地方会
  • Place of Presentation: 京都
  • Year and Date: 2014-11-23
• [Presentation] 多施設肥満症コホートにおける脳心血管イベント発症予測指標の探索-CAVI・新規酸化LDL- (2014)
  • Author(s): 浅原哲子、村中和哉、佐々木洋介、山陰一、小谷和彦、山田努、荒木里香、岡嶋泰一郎、田邉真紀人、大石まり子、島津章
  • Organizer: 第35回日本肥満学会
  • Place of Presentation: 宮崎
  • Year and Date: 2014-10-24 – 2014-10-25
• [Presentation] 肥満における内臓・皮下脂肪蓄積と線維化関連因子TSP-1との関連性 (2014)
  • Author(s): 松尾禎之、田中将志、佐々木洋介、山陰一、村中和哉、猪飼伊和夫、畑啓昭、島津章、井上真由美、Chun Tae-Hwa、浅原哲子
  • Organizer: 第35回日本肥満学会
  • Place of Presentation: 宮崎
  • Year and Date: 2014-10-24 – 2014-10-25
• [Presentation] 頸動脈プラーク浸潤マクロファージ及び末梢血単球のM1/M2様形質に及ぼす肥満・糖尿病の影響 (2014)
  • Author(s): 田中将志、松尾禎之、佐々木洋介、山陰一、村中和哉、塚原徹也、島津章、浅原哲子
  • Organizer: 第35回日本肥満学会
  • Place of Presentation: 宮崎
  • Year and Date: 2014-10-24 – 2014-10-25
• [Presentation] Effect of Sitagliptin and Vildagliptin, Dipeptidyl Peptidase-4 Inhibitors, on M1/M2-like Phenotypes of Peripheral Blood Monocytes and Arterial Stiffness in Type 2 Diabetic Patients. (2014)
  • Author(s): Noriko Satoh-Asahara, Masashi Tanaka, Yoshiyuki Matsuo, Hajime Yamakage, Kazuya Muranaka, Yousuke Sasaki, Shinji Odori, Shigeo Kono, Akira Shimatsu
  • Organizer: 9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress
  • Place of Presentation: 京都
  • Year and Date: 2014-09-12 – 2014-09-14
• [Presentation] Unbalanced M1/M2 phenotypes of monocytes and hyperglycemia associate with M1/M2 macrophages in the carotid atherosclerotic plaque in the patients with obesity and diabetes undergoing carotid endarterectomy. (2014)
  • Author(s): Masashi Tanaka, Yoshiyuki Matsuo, Yousuke Sasaki, Hajime Yamakage, Kazuya Muranaka, Tetsuya Tsukahara, Akira Shimatsu, Noriko Satoh-Asahara
  • Organizer: 9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress
  • Place of Presentation: 京都
  • Year and Date: 2014-09-12 – 2014-09-14
• [Presentation] Sexually dimorphic, fat depot-dependent expression of a fibrogenic adipokine, thrombospondin 1 (THBS1) in human obesity. (2014)
  • Author(s): Yoshiyuki Matsuo, Masashi Tanaka, Yousuke Sasaki, Hajime Yamakage, Kazuya Muranaka, Iwao Ikai, Hiroaki Hata, Akira Shimatsu, Mayumi Inoue, Tae-Hwa Chun, Noriko Satoh-Asahara
  • Organizer: 9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress
  • Place of Presentation: 京都
  • Year and Date: 2014-09-12 – 2014-09-14
• [Presentation] 頸動脈プラークのM1/M2マクロファージ浸潤と炎症性サイトカイン産生に対する肥満・糖尿病の影響 (2014)
  • Author(s): 田中将志、松尾禎之、佐々木洋介、山陰一、村中和哉、塚原徹也、島津章、浅原哲子
  • Organizer: 日本内分泌学会第32回内分泌代謝学サマーセミナー
  • Place of Presentation: 山梨
  • Year and Date: 2014-07-10 – 2014-07-12
• [Presentation] 多施設共同前向きコホート研究における肥満症の脳心血管イベント発症予測指標の探索-CAVI測定の臨床的意義- (2014)
  • Author(s): 浅原哲子、村中和哉、佐々木洋介、山陰一、小谷和彦、山田努、荒木里香、岡嶋泰一郎、田邉真紀人、大石まり子、島津章
  • Organizer: 第87回日本内分泌学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2014-04-24 – 2014-04-26
• [Remarks] 京都医療センター臨床研究センター内分泌代謝高血圧研究部
  • URL: http://www.hosp.go.jp/~kyotolan/html/guide/medicalinfo/clinicalresearch/endocrinology/endocrinology.html