Regulating mechanism of mitochondrial function by BDNF in the skeletal muscle
Project/Area Number |
26750331
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Applied health science
|
Research Institution | Hokkaido University |
Principal Investigator |
Takada Shingo 北海道大学, 医学研究科, 博士研究員 (60722329)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | ミトコンドリア / 骨格筋 / マイオカイン / 心不全 / 老化・加齢 / マイトファジー / 脳由来神経栄養因子 / ミトコンドリアダイナミクス / 運動能力 / ミトコンドリア機能 / 老化 / エネルギー代謝 / 筋収縮 |
Outline of Final Research Achievements |
Brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, has been known to be increased by exercise training and associated with exercise capacity (Int J Cardiol 2013), which are dependent on mitochondrial function in the skeletal muscle. BDNF-TrkB pathway may play an important role in the improvement of the beneficial effects of exercise training on the exercise capacity and skeletal muscle mitochondrial function.
|
Report
(4 results)
Research Products
(45 results)
-
-
[Journal Article] Pioglitazone improves whole-body aerobic capacity and skeletal muscle energy metabolism in patients with metabolic syndrome2017
Author(s)
Yokota T, Kinugawa S, Hirabayashi K, Suga T, Takada S, Omokawa M, Kadoguchi T, Takahashi M, Fukushima A, Matsushima S, Yamato M, Okita K, Tsutsui H
-
Journal Title
J Diabetes Investig
Volume: 印刷中
Issue: 4
Pages: 1-6
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes.2016
Author(s)
Mizushima, W., Takahashi , H., Watanabe, M., Kinugawa, S., Matsushima, S., Takada, S., Yokota, T., Furihata, T., Matsumoto, J., Tsuda, M., Chiba, I., Nagashima, S., Yanagi, S., Matsumoto, M., Nakayama, K.I., Tsutsui, H. and Hatakeyama, S.
-
Journal Title
J. Mol. Cell. Cardiol.
Volume: 100
Pages: 43-53
DOI
NAID
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
-
[Journal Article] Dipeptidyl peptidase-4 inhibitor improved exercise capacity and mitochondrial biogenesis in mice with heart failure via activation of GLP-1 receptor signaling.2016
Author(s)
Takada S, Masaki Y, Kinugawa S, Matsumoto J, Furihata T, Mizushima W, Kadoguchi T, Fukushima A, Homma T, Takahashi M, Harashima S, Matsushima S, Yokota T, Tanaka S, Okita K, Tsutsui H
-
Journal Title
Cardiovasc Res
Volume: 111
Issue: 4
Pages: 338-347
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
-
[Journal Article] The experimental model of transition from compensated cardiac hypertrophy to failure created by transverse aortic constriction in mice.2016
Author(s)
Furihata T, Kinugawa S, Takada S, Fukushima A, Takahashi M, Homma T, Masaki Y, Tsuda M, Matsumoto J, Mizushima W, Matsushima S, Yokota T, Tsutsui H.
-
Journal Title
IJC Heart & Vasculature
Volume: 11
Pages: 24-28
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
-
[Journal Article] Serum Myostatin Levels are Independently Associated with Skeletal Muscle Wasting in Patients with Heart Failure.2016
Author(s)
Furihata T, Kinugawa S, Fukushima A, Takada S, Homma T, Masaki Y, Abe T, Yokota T, Oba K, Okita K, Tsutsui H.
-
Journal Title
International Journal of Cardiology
Volume: 220
Pages: 483-487
DOI
NAID
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
-
[Journal Article] Direct renin inhibitor ameliorated insulin resistance by improving insulin signaling and oxidative stress in the skeletal muscle from post-infarct heart failure in mice.2016
Author(s)
Fukushima A, Kinugawa S, Takada S, Matsumoto J, Furihata T, Mizushima W, Tsuda M, Yokota T, Matsushima S, Okita K, Tsutsui H
-
Journal Title
Eur J Pharmacol
Volume: 779
Pages: 147-156
DOI
NAID
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
-
-
-
-
[Journal Article] Sesamin prevents decline in exercise capacity and impairment of skeletal muscle mitochondrial function in mice with high-fat diet-induced diabetes2015
Author(s)
Takada S, Kinugawa S, Matsushima S, Takemoto D, Furihata T, Mizushima W, Fukushima A, Yokota T, Ono Y, Shibata H, Okita K, Tsutsui H
-
Journal Title
Exp Physiol
Volume: 100
Issue: 11
Pages: 1319-30
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
[Journal Article] AST-120 ameliorates lowered exercise capacity and mitochondrial biogenesis in the skeletal muscle from mice with chronic kidney disease via reducing oxidative stress.2015
Author(s)
Nishikawa M, Ishimori N, Takada S, Saito A, Kadoguchi T, Furihata T, Fukushima A, Matsushima S, Yokota T, Kinugawa S, Tsutsui H
-
Journal Title
Nephrol Dial Transplant.
Volume: in press
Issue: 6
Pages: 182-188
DOI
NAID
Related Report
Peer Reviewed
-
[Journal Article] Serum brain-derived neurotrophic factor level predicts adverse clinical outcomes in patients with heart failure2015
Author(s)
Fukushima A, Kinugawa S, Homma T, Masaki Y, Furihata T, Yokota T, Matsushima S, Takada S, Kadoguchi T, Oba K, Okita K, Tsutsui H
-
Journal Title
J Card Fail
Volume: 21
Issue: 4
Pages: 300-306
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] Angiotensin II can directly induce mitochondrial dysfunction, decrease oxidative fibre number and induce atrophy in mouse hindlimb skeletal muscle.2015
Author(s)
Kadoguchi T, Kinugawa S, Takada S, Fukushima A, Furihata T, Homma T, Masaki Y, Mizushima W, Nishikawa M, Takahashi M, Yokota T, Matsushima S, Okita K, Tsutsui H
-
Journal Title
Exp Physiol
Volume: 100
Issue: 3
Pages: 312-322
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
[Journal Article] (Pro)renin receptor in skeletal muscle is involved in the development of insulin resistance associated with postinfarct heart failure in mice2014
Author(s)
Fukushima A, Kinugawa S, Takada S, Matsushima S, Sobirin MA, Ono T, Takahashi M, Suga T, Homma T, Masaki Y, Furihata T, Kadoguchi T, Yokota T, Okita K, Tsutsi H
-
Journal Title
Am J Physiol Endocrinol Metab
Volume: 307
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] Intramyocellular Lipid is Increased in the Skeletal Muscle of Patients with Dilated Cardiomyopathy with Lowered Exercise Capacity2014
Author(s)
Hirabayashi K, Kinugawa S, Yokota T, Takada S, Fukushima S, Suga T, Takahashi M, Ono T, Morita N, Omokawa M, Harada K, Oyama-Manabe N, Shirato H, Matsushima S, Okita K, Tsutsui H
-
Journal Title
Int J Cardiol
Volume: 176
Pages: 1110-1112
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] Combination of exercise training and diet restriction normalizes limited exercise capacity and impaired skeletal muscle function in diet-induced diabetic mice2014
Author(s)
Suga T, Kinugawa S, Takada S, Kadoguchi T, Fukushima A, Homma T, Masaki Y, Furihata T, Takahashi M, Sobirin MA, Ono T, Hirabayashi K, Yokota T, Tanaka S, Okita K, Tsutsui H
-
Journal Title
Endocrinology
Volume: 155
Pages: 68-80
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] Pioglitazone ameliorates the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice2014
Author(s)
Takada S, Hirabayashi K, Kinugawa S, Yokota T, Matsushima S, Suga T, Kadoguchi T, Fukushima A, Homma T, Mizushima W, Masaki Y, Furihata T, Katsuyama R, Okita K, Tsutsui H
-
Journal Title
Eur J Pharmacol
Volume: 740
Pages: 690-696
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Recombinant Human BDNF Can Mimic Effects of Exercise Training in Mice.2015
Author(s)
Takada S, Kinugawa S, Matsushima S, Yokota T, Mizushima W, Furihata T, Matsumoto J, Tsuda M, Fukushima A, Okita K, Tsutsui H.
Organizer
88th Scientific Session of American Heart Association
Place of Presentation
Orange County Convention Ctr, Orlando, Florida, USA.
Year and Date
2015-11-07
Related Report
Int'l Joint Research
-
-
-
[Presentation] DPP-4 inhibitor improved exercise capacity in mice with heart failure.2015
Author(s)
Takada S, Kinugawa S, Masaki Y, Kadoguchi T, Fukushima A, Furihata T, Kudo M, Matsumoto J, Tsuda M, Matsushima S, Yokota T, Okita K, Tsutsui H.
Organizer
第21回日本心臓リハビリテーション学会学術集会
Place of Presentation
福岡国際会議場、福岡県、福岡市
Year and Date
2015-07-18
Related Report
-
-
[Presentation] Brain-Derived Neurotrophic Factor Maintains Exercise Capacity And Mitochondrial Function In The Skeletal Muscle Through Ampk-Pgc1α Signaling2014
Author(s)
Takada S, Kinugawa S, Matsushima S, Mizushima W, Fukushima A, Furihata T, Kadoguchi T, Yokota T, Suga T, Okita K, Tsutsui H
Organizer
American Heart Association Scientific Sessions 2014
Place of Presentation
Chicago, USA
Year and Date
2014-11-15 – 2014-11-19
Related Report
-
-
[Presentation] Sesamin Improves Lowered Exercise Capacity, Mitochondrial Dysfunction in the Skeletal Muscle from High Fat Diet-Induced Diabetic Mice2014
Author(s)
Takada S, Kinugawa S, Takemoto D, Masaki Y, Kadoguchi T, Yokota T, Matsushima S, Fukushima A, Homma T,Furihata T, Suga T, Katsuyama R, Ono Y, Shibata H, Okita K, Tsutsui H
Organizer
50th EASD Annual Meeting 2014
Place of Presentation
Vienna, Austria
Year and Date
2014-09-15 – 2014-09-18
Related Report
-