Elucidation of mechanisms underlying Zizimin family gene-dependent immunosenescence
| Project/Area Number |
26750350
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | National Center for Geriatrics and Gerontology |
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Principal Investigator |
Matsuda Takenori 国立研究開発法人国立長寿医療研究センター, その他部局等, 流動研究員 (30646477)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | B細胞 / 老化 / 免疫 / 感染 / 肺炎 / Stat6 / Dock11 / Dock10 / 辺縁帯 / B1 / Zizimin2 / 加齢 |
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| Outline of Final Research Achievements |
This study revealed that Zizimin2, of which expression level is decreased with aging, increases splenic marginal zone B cell and peritoneal cavity B1b cell number in mice. In addition, the expression level in those cells from aged mice was significantly lower than that from young mice. Importantly, we also demonstrated some regulatory elements for the expression upstream from murine Zizimin2 gene transcription start site. It will be required in the near future if activation of Zizimin2 gene rejuvenates the immunological function of elderly people or mice.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] Rhof promotes murine marginal zone B cell development2014
Author(s)
Kishimoto M, Matsuda T, Yanase S, Katsumi A, Suzuki N, Ikejiri M, Takagi A, Ikawa M, Kojima T, Kunishima S, Kiyoi H, Naoe T, Matsushita T, Maruyama M
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Journal Title
Nagoya Journal of Medical Science
Volume: 76
Pages: 293-305
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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