| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
It is thought that human has a mechanism protecting biomolecules from oxidative stress because reactive oxygen species (ROS) generally injure biomolecules. 8-Nitro-cGMP formed from reactive nitrogen species (RNS) and guanine nucleotide is an important mediator of autophagy and plays an important role in protein regulation. However, its removal mechanism from cells remains to be elucidated. In this study, we focused on what molecules are related to this mechanism and revealed the involvement of metal species.
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