| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The dynamic behavior of the actin cytoskeleton is a critical part of most cellular activities, e.g., membrane trafficking, cell movement and neurite extension. Therefore, visualization of actin cytoskeleton dynamics is essential to understand its roles in regulating cellular functions. In the present study, novel small molecule based fluorescence probe for F-actin visualization probes were successfully developed. The developed probe is simple to use, and has sufficiently high sensitivity and specificity for actin cytoskelton. It is also showed that the probe was applicable for live cell fluorescence imaging method. This would be nice piece of work a potentially important to researchers interested in the biology associated with actin dynamics.
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