| Project/Area Number |
26750380
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Basic / Social brain science
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Uematsu Akira 国立研究開発法人理化学研究所, 脳科学総合研究センター, 基礎科学特別研究員 (90716242)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 青斑核 / ノルアドレナリン / 恐怖条件づけ / 消去 / ノルアドレナリン神経 / 扁桃体 |
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| Outline of Final Research Achievements |
In this project, we first identified the functional role of locus coeruleus (LC) noradrenaline (NA) neurons by optogenetic manipulation. We found that shock evoked activity of LC-NA is necessary for fear learning and tone evoked activity is required for extinction learning. Consistent with these finding, in-vivo electrophysiology revealed that LC-NA neurons identified with optogenetic inhibition are mostly shock responsive and cue-evoked response is increased after fear conditioning. Finally we tested if LC-NA neurons have heterogeneous functions using recombinant rabies virus expressing light-induced hyperpolarization pump. One population projecting to the amygdala is engaged during aversive emotional learning while a separate population projecting to the medial prefrontal cortex (mPFC) is recruited to extinguish aversive emotional responses when they are no longer appropriate.
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