| Project/Area Number |
26750382
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Brain biometrics
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
KASAI Masatoshi 生理学研究所, 発達生理学研究系, 特別協力研究員 (70625269)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 上丘 / マウス / ２光子顕微鏡 / in vivo イメージング / 側方抑制 / 視覚 / サッカード / 眼球運動 / in vivo カルシウムイメージング / サッケード / カルシウムイメージング / in vivo |
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| Outline of Final Research Achievements |
The superior colliculus (SC) is a brainstem center which plays essential roles in mediating the signal for sensory-motor translation. It has been hypothesized that horizontal excitatory and inhibitory interaction in the sSC is important for target selection, however; the way of neuronal implementation remained elusive, especially at the neuronal population level.
In this study we applied in vivo two-photon Ca2+ imaging and simultaneously recored neuronal population activities evoked by visual stimuli. I examined excitatory and inhibitory interaction by presenting spatially separated visual stimuli and stimulus with different sizes. I found that Mexican hat-like lateral interaction is implemented as a neuronal population activity. I also recorded eye movements from head-fixed awake mice. To induce saccade-like eye movement frequently, I tested several kinds of visual stimuli which contains motional information.
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